A5102962776- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Cerebrovascular and Carotid Artery Diseases
- Functional Brain Connectivity Studies
- Advanced biosensing and bioanalysis techniques
- Neuroscience and Neuropharmacology Research
- Monoclonal and Polyclonal Antibodies Research
- Acute Ischemic Stroke Management
- Photosynthetic Processes and Mechanisms
- Nanoparticle-Based Drug Delivery
- Mosquito-borne diseases and control
- MicroRNA in disease regulation
- Pharmacological Effects of Natural Compounds
- Connective tissue disorders research
- Phytochemicals and Antioxidant Activities
- Virus-based gene therapy research
- Luminescence and Fluorescent Materials
- Cancer-related molecular mechanisms research
- Advanced X-ray Imaging Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Insect symbiosis and bacterial influences
- Bone and Dental Protein Studies
- Natural Antidiabetic Agents Studies
- Vagus Nerve Stimulation Research
- Cardiovascular Disease and Adiposity
Liaocheng University
2020-2025
Changsha University of Science and Technology
2025
Zhengzhou Central Hospital
2021-2025
Capital Medical University
2018-2024
Hunan University
2021-2024
State Key Laboratory of Chemobiosensing and Chemometrics
2021-2024
Beijing Sanbo Brain Hospital
2018-2024
Hunan University of Traditional Chinese Medicine
2024
South China University of Technology
2021-2024
Wuhan University
2021-2023
Zika virus uses a convoluted RNA fold to produce noncoding RNAs associated with pathogenesis.
The current epidemic of Zika virus (ZIKV) has underscored the urgency to establish experimental systems for studying viral replication and pathogenesis, countermeasure development. Here we report two ZIKV replicon systems: a luciferase that can differentiate between translation RNA synthesis; stable carrying cell line be used screen characterize inhibitors replication. transient was evaluate effect an NS5 polymerase mutation on synthesis analyze known inhibitor. developed into 96-well format...
As one of the most common chronic diseases in world, osteoporosis occurs especially postmenopausal women. Circular RNAs (circRNAs) are emerging as major drivers human disease. The aim present study was to analyse circRNA expression profiles and explore clinical significance regulatory molecular mechanism hsa_circ_0006859 during osteoporosis.
Abstract A “turn‐on” fluorescent sensing strategy was developed for ultrasensitive detection of heavy metal mercury ion (Hg 2+ ) directly in water. It utilized an aqueous soluble aggregation‐induced emission (AIE)‐active probe, named 1,1,2,2‐tetrakis(4‐(1H‐tetrazol‐5‐yl)phenyl)ethene (TPE‐4TA), composing a luminescent tetraphenylene core and multiple anionic tetrazolate spawns. The probe retained dark when molecularly dissolved However, ions can ligate with groups to form infinite...
Dodecyl phlorizin and polydatin derivatives are safe promising in vivo hypoglycemic active compounds that can inhibit the hydrolytic activity of α-glucosidase intestinal glucose absorption.
To regulate interfacial reactions on Zn anode, it is the key to tune dielectric properties of interface via polarizability, coordination, and solubility anion.
Ischemic stroke is a leading cause of death and disability, the treatment options are limited. Recent studies demonstrated that promising applications gold nanoparticles (Au-NPs) as intrinsic therapeutics; however, little known about effect Au-NPs on cerebral ischemia-reperfusion (I/R) injury. In this paper, role I/R injury in rat middle artery occlusion (MCAO) model was investigated using citrate-capped 5 nm 20 Au-NPs. It found administration led to remarkable amelioration neurologic...
Puerarin derived from<italic>Pueraria</italic>induces mesenteric endothelium-dependent vasodilation involving the TRPV4-IK<sub>Ca</sub>/SK<sub>Ca</sub>pathway, exhibiting antihypertensive activity against high-salt-induced hypertension.
Sterculia nobilis Smith pericarp is a by-product of tropical and subtropical fruit Smith, the functional activity phytochemical composition which have not been widely reported. In this work, LC-ESI-MS/MS-MRM technique was used for qualitative quantitative analysis 16 phenolic compounds in ethyl acetate fraction extract (EAF). Luteolin-7-O-glucoside, epicatechin gallate apigetrin were principal phenolics EAF. The hypoglycemic EAF examined by α-glucosidase α-amylase inhibition models....
Escin, a natural mixture of triterpenoid saponin isolated from the seed horse chestnut, is reported to have potent antiulcer activity against ethanol-induced gastric mucosal lesions. This study investigated possible mechanisms underlying gastroprotective effect escin indomethacin-induced ulcer in mice. Gastric ulceration was induced by single intragastric administration indomethacin (18 mg/kg). The mice underwent treatment with at doses 0.45, 0.9 or 1.8 mg/kg. lesion estimated...
Osteogenesis imperfecta (OI) is a rare heritable skeletal disorder which mainly caused by defected type I collagen. Autosomal recessive OI (AR-OI) mutations of genes that are responsible for collagen modification and folding, often associated with more severe phenotypes. Due to the limited number patients, it has been difficult study mutation spectrum as well correlation genotype phenotype. This recruited Chinese cohort 74 AR-OI families, aiming establish examine genotypic phenotypic...
It has been shown that intracranial atherosclerotic stenosis (ICAS) heterogeneous features in terms of plaque instability and vascular remodeling. Therefore, quantitative information on the changes atherosclerosis lenticulostriate arteries (LSAs) may potentially improve understanding pathophysiological mechanisms underlying stroke guide treatment work-up strategies. Our present study aimed to use a novel whole-brain high-resolution cardiovascular magnetic resonance imaging (WB-HRCMR) assess...
We provide a review on how luminescence functionality can be integrated with modifiable hydrogels to extend the frontiers of luminescent materials for health technologies.
Saxifraga species are widely distributed in alpine and arctic regions the Northern hemisphere. Highly morphological diversity within this genus brings great difficulties for identification, their typical highland living properties make it interesting how they adapt to extreme environment. Here, we newly generated chloroplast (cp) genomes of two compared them with another five cp understand characteristics potential roles adaptation. The genome size, structure, gene content, GC codon usage...
Plant organelle genomes are a valuable resource for evolutionary biology research, yet their genome architectures, patterns and environmental adaptations poorly understood in many lineages. Rhodiola species is type of flora mainly distributed highland habitats, with high medicinal value. Here, we assembled the three (R. wallichiana, R. crenulata sacra) collected from Qinghai-Tibet plateau (QTP), compared structure, gene content, structural rearrangements, sequence transfer evolution...
A new strategy for preparing amphibious ZnO quantum dots (QDs) with blue fluorescence within hyper-branched poly(ethylenimine)s (HPEI) was proposed in this paper. By changing [Zn2+]/[OH−] molar ratio and heating time, QDs a yields (QY) of 30% ethanol were obtained. Benefiting from the property HPEI, ZnO/HPEI nanocomposites could be dissolved chloroform water, acquiring QY 53%, 11% water. strategy, nano-composites applied not only optoelectronics, but also biomedical fields (such as...
Statins have proven to exert protective effects in patients with symptomatic intracranial atherosclerotic stenosis (SICAS). It is unclear whether intensive lipid-lowering therapy (ILLT) can ameliorate atherosclerosis asymptomatic ICAS (AICAS). A single-center, prospective cohort study was performed 71 AICAS therapy. Vascular stenoses were evaluated transcranial color-coded sonography (TCCS) before and after statin treatment. With target therapeutic level of low-density lipoprotein...