A5101514891- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Plant responses to water stress
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Otolaryngology and Infectious Diseases
- Mycobacterium research and diagnosis
- Infectious Diseases and Tuberculosis
- interferon and immune responses
- Orthopedic Infections and Treatments
- Plant nutrient uptake and metabolism
- Streptococcal Infections and Treatments
- Phytochemistry and Biological Activities
- Circular RNAs in diseases
- Colorectal Cancer Treatments and Studies
- MicroRNA in disease regulation
- Salivary Gland Disorders and Functions
- Natural product bioactivities and synthesis
- Family Support in Illness
- Childhood Cancer Survivors' Quality of Life
- Nuclear Structure and Function
- NF-κB Signaling Pathways
- Palliative Care and End-of-Life Issues
- Mitochondrial Function and Pathology
Shanghai Stomatological Hospital
2023-2025
Fudan University
2025
First Affiliated Hospital of Anhui Medical University
2017-2025
Anhui Medical University
2017-2025
Shanghai Ninth People's Hospital
2022-2024
Shanghai Jiao Tong University
2022-2024
National Clinical Research Center for Digestive Diseases
2022-2023
Yancheng Teachers University
2022-2023
Nanchang University
2020-2022
China Medical University
2022
Rationale: Abnormal metabolic states contribute to a variety of diseases, including cancer. RNA modifications have diverse biological functions and are implicated in cancer development, gastric (GC). However, the direct relationship between glucose homeostasis 4-acetylcytosine (ac4C) modification GC remains unclear. Methods: The prognostic value acetyltransferase NAT10 expression was evaluated human cohort. Additionally, preoperative PET/CT data from patients Micro-PET/CT imaging mice were...
Waterlogging is one of the major abiotic stresses in barley and greatly reduces grain yield quality. To explore mechanism controlling waterlogging tolerance barley, physiological, anatomical transcriptional analyses were performed two contrasting varieties, viz. Franklin (susceptible) TX9425 (tolerant).Compared to Franklin, had more adventitious roots aerenchymas higher antioxidant enzyme activities. A total 3064 5693 differentially expressed genes (DEGs) identified after 24 h 72 treatment,...
The tumor microenvironment (TME) is associated with disease outcomes and treatment response in colon cancer. Here, we constructed a TME-related gene signature that prognosis of survival may predict to immunotherapy cancer.We calculated immune stromal scores for 385 cancer samples from Cancer Genome Atlas (TCGA) database using the ESTIMATE algorithm. We identified nine prognostic genes Cox regression analysis. evaluated associations between protein expression, extent cell infiltrate, patient...
Acinar epithelial cell atrophy in secretory glands is a hallmark of primary Sjögren's syndrome (pSS), the cause which far from elucidated.We examined role acinar by focusing on metabolism glandular cells and mitochondria pSS environment.After confirming presence high-lactate environment labial human patients, we used A253 line NOD/Ltj mice as models to investigate metabolic changes salivary gland vitro vivo.We found that produced high levels IL-6, IL-8, IFN-α, IFN-β TNF-α exhibited...
Survival rates for patients with gastric cancer, especially the advanced form, remain poor and development of targeted treatments is hampered by a lack efficient biological targets. Poly( rC ) binding protein 2 ( PCBP 2) an RNA ‐binding that contributes to mRNA stabilization, translational silencing enhancement it has been implicated as promoter cancer growth. In present study, we demonstrated expression level was higher in human tissues compared adjacent normal tissues. A high correlated...
Waterlogging is the primary abiotic factor that destabilizes yield and quality of barley (Hordeum vulgare L.). However, genetic basis waterlogging tolerance remains poorly understood. In this study, we conducted a genome-wide association study (GWAS) by involving 106,131 single-nucleotide polymorphisms (SNPs) with score (WLS) 250 accessions in two years. Out 72 SNPs were found to be associated WLS, 34 detected at least environments. We further performed transcriptome analysis root samples...
Previous studies have shown that abnormal metabolic reprogramming in CD4+ T cells could explain the occurrence of several autoimmune disorders, including Sjogren's syndrome (SS). However, therapeutic targets metabolism remain to be explored. Here, we report glutaminase 1 (Gls1), a pivotal factor glutaminolysis, might involved pathogenesis SS. The expression Gls1 was upregulated infiltrated labial and circulating SS patients. Inhibiting with BPTES significantly abolished proliferation rate,...
Cuproptosis is a newly discovered non-apoptotic form of cell death that may be related to the development tumors.Nonetheless, potential role cuproptosis-related lncRNAs in tumor microenvironment (TME) formation and patient-tailored treatment optimization gastric cancer (GC) still unclear.In this study, six-lncRNA signature was constructed quantify molecular patterns GC using LASSO-Cox regression model.Receiver operating characteristic (ROC) curves, C-index independent prognostic analysis...
N6-methyladenosine (m6A) RNA modification plays an important role in regulating tumor microenvironment (TME) infiltration. However, the relationship between expression pattern of m6A-related long non-coding RNAs (lncRNAs) and immune gastric cancer (GC) is unclear.In this study, 23 lncRNAs were identified by Pearson's correlation analysis univariate Cox regression analysis. According to these lncRNAs, we two distinct molecular clusters consensus clustering compared differences TME enriched...
Ten new phenylpropanoid glucosides, tadehaginosides A-J (1-10), and the known compound tadehaginoside (11) were obtained from Tadehagi triquetrum. These glucosides structurally characterized through extensive physical chemical analyses. Compounds 1 2 represent first set of dimeric derivatives with an unusual bicyclo[2.2.2]octene skeleton, whereas compounds 3 4 contain a unique cyclobutane basic core in their carbon scaffolds. The effects these on glucose uptake C2C12 myotubes evaluated....
Alternative polyadenylation (APA) is an important post-transcriptional regulation in eukaryotic cells. It plays considerable roles many biological processes and diseases, such as cell differentiation, proliferation cancer. Colorectal cancer (CRC) one of the most common malignancies worldwide, which among top five incidence mortality all cancers China. Although there have been some studies on APA CRC, normal carcinoma samples used for genome-wide profiling were not matched. The purpose this...
Introduction: Sjögren's syndrome (SS) is a chronic autoimmune disorder characterized by exocrine gland dysfunction, leading to loss of salivary function. Histological analysis glands from SS patients reveals high infiltration immune cells, particularly activated CD4+ T cells. Thus, interventions targeting abnormal activation cells may provide promising therapeutic strategies for SS. Here, we demonstrate that Hect, uba, and wwe domain containing 1 (HUWE1), member the eukaryotic Hect E3...
Worldwide, the incidence rate of gastric cancer ranks fifth, and mortality third among all malignant tumors. However, pathogenesis remains poorly understood. In this study, we demonstrated that expression level NELFE is higher in human tissues than adjacent nontumor tissues. A high associated with worse postoperative overall survival (OS) relapse-free (RFS) rates patients cancer. Moreover, correlated tumor grade lymph node metastasis patients. Knockdown dramatically inhibits cell...
Hepatocellular carcinoma (HCC) is a common malignancy with poor prognosis worldwide. However, the pathogenesis of HCC remains poorly understood. In this study, we found that NOL12 was significantly overexpressed in independent datasets from TCGA database. We confirmed expression level upregulated human tissues and cell lines by RT-qPCR. High associated worse reduced overall survival (OS), high pathological grade, node metastasis, advanced clinical stage patients HCC. Moreover, knockdown...
Abstract Objective: To study the role of long non-coding RNA (lncRNA) CRYM-AS1 in human gastric cancer. Methods: Expression levels cell lines and clinical tissues were examined by RT-qPCR. The association between clinicopathological parameters / survival rates cancer patients was analyzed.Cell functional experiments including MTT assay, glucose consumption lactate production ATP detection performed to examine aerobic glycolysis proliferation cells. Subcellular fractionation location...
Abstract Objective We aimed to investigate the value of individual laboratory tests and combinations for predicting disease severity. Methods retrospectively reviewed 62 patients with space infections in oral maxillofacial head neck regions. Patients were divided into three groups according Laboratory associated severity identified. Results As infection increased, leukocytes, neutrophils, C‐reactive protein (CRP), procalcitonin (PCT), soluble interleukin receptor (sILR) 2, IL6, creatinine...