A5056103685- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- SARS-CoV-2 and COVID-19 Research
- Eosinophilic Esophagitis
- Animal Virus Infections Studies
- Immunotherapy and Immune Responses
- Gas Sensing Nanomaterials and Sensors
- Bacterial Infections and Vaccines
- T-cell and B-cell Immunology
- Viral gastroenteritis research and epidemiology
- Industrial Technology and Control Systems
- Bone Metabolism and Diseases
- Asthma and respiratory diseases
- HIV Research and Treatment
- Influenza Virus Research Studies
- Sirtuins and Resveratrol in Medicine
- CAR-T cell therapy research
- Mechanical and Optical Resonators
- COVID-19 Clinical Research Studies
- Analytical Chemistry and Sensors
- Inflammasome and immune disorders
- Nerve injury and regeneration
- Image Enhancement Techniques
- Bone Tissue Engineering Materials
- Belt Conveyor Systems Engineering
Dalian Polytechnic University
2022-2024
Harbin Institute of Technology
2022-2024
Australian National University
2005-2024
Shanghai Jiao Tong University
2024
Waseda University
2024
Cedars-Sinai Medical Center
2024
Shandong Tumor Hospital
2023
Shandong First Medical University
2023
Shanghai Institute of Quality Inspection and Technical Research
2021
Shandong Special Equipment Inspection Institute
2021
Aims: Parkinson's disease (PD) heavily affects humans and little is known about its cause pathogenesis. Sirtuin 3 (Sirt3) plays a key role in regulating mitochondrial dysfunction, which the main of DAergic neuronal loss PD. We investigated mechanisms neuroprotective Sirt3 survival. Results: was reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP)-treated neurons with overexpression being neuroprotective. identified that interacted manganese superoxide dismutase (SOD2) adenosine...
Triple-negative breast cancer (TNBC) is an aggressive subtype of cancer. Patients with TNBC have poor overall survival because limited molecular therapeutic targets. Recently, exosomes been recognized as key mediators in progression, but the components and function TNBC-derived remain unknown. The main goal this study was to reveal proteomic landscape serum derived from ten patients 17 healthy donors identify potential Using a tandem mass tag–based quantitative proteomics approach, we...
Neuroblastoma is the most common pediatric extracranial solid tumor with a broad spectrum of clinical behavior and poor prognosis. Despite intensive multimodal therapy, ongoing trials, basic science investigations, neuroblastoma remains complex medical challenge long-term survival rate less than 40%. In our study, we found that resveratrol (3, 5, 4′-trihydroxystilbene, RSV), naturally occurring phytoalexin, possesses an anticancer activity through blocking cell growth inducing apoptosis in...
Efforts to develop and deploy effective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue at pace. Here, we describe rational antigen design through manufacturability vaccine efficacy of a prefusion-stabilised spike (S) protein, Sclamp, in combination with the licensed adjuvant MF59 'MF59C.1' (Seqirus, Parkville, Australia).A panel recombinant Sclamp proteins were produced Chinese hamster ovary screened vitro select lead candidate. The structure this was...
This paper addresses the development of a new algorithm for parameter estimation ordinary differential equations. Here, we show that (1) simultaneous approach combined with orthogonal cyclic reduction can be used to reduce problem an optimization subject fixed number equality constraints without need structural information devise stable embedding in case non-trivial dichotomy and (2) Newton approximation Hessian Lagrangian function should cases where hypothesized models are incorrect or only...
Host genetic factors and environment including hepatitis B virus (HBV) genotypes are widely studied for the different outcomes of HBV infection. Recent studies suggest that tumour necrosis factor-alpha (TNF-alpha) plays a pivotal role in viral clearance host immune response to HBV, capacity TNF-alpha production individuals is influenced by major component. In this study, we aimed explore whether single-nucleotide polymorphisms (SNPs) promoter associated with infection Chinese Han population....
Purpose: The purpose of this study was to assess the effects biomimetic intrafibrillar mineralized collagen (IMC) bone scaffold materials on regeneration and underlying biological mechanisms. Materials methods: A critical-sized defect in rat femur created; then IMC, extrafibrillar collagen, nano-hydroxyapatite were grafted into defect. Ten weeks after implantation, micro-computed tomography histology applied evaluate regeneration. Furthermore, microarray technology for transcriptional...
Abstract Spontaneous bone regeneration could occur to reestablish mandibular bony continuity in patients who underwent partial or total mandibulectomy for tumors with periosteum-preserving. However, scarce data is available related the precise role of periosteum this regeneration. Therefore we aimed investigate gene expression that were involved Mandibular segmental defects created six mini-pigs preserved. The and control site harvested at 1 2 weeks. Gene ontology (GO) analysis showed...
Abstract This study demonstrates that the fate of a vaccine is influenced by cytokines produced innate lymphoid cells (ILC) recruited to vaccination site, and it route adjuvant dependent. Intranasal virus induced ST2/IL-33R + ILC2 in lung, while intramuscular exclusively IL-25R muscle. Interestingly, larger proportion IL-13 ILC2s were detected muscle following i.m. viral vector compared lung post i.n. delivery. These observations revealed main source at site (24 h vaccination) responsible...
Abstract IL-4 production is associated with low-avidity, poorly cytotoxic T cell induction that contributes to viral immune evasion and the failure of cell-based vaccines. Yet, precise mechanisms regulate signalling in cells remain elusive. Mounting evidence indicates can dynamically alter their IL-4/IL-13 receptor signature modulate downstream outcomes upon pathogen encounter. Here, we describe how naïve (CD62L + CD44 lo–mid ) CD4 CD8 distinctly engage both STAT6 STAT3 response IL-4. We...
This study demonstrates that route and viral vector can significantly influence the innate lymphoid cells (ILC) dendritic (DC) recruited to vaccination site, 24 h post delivery. Intranasal (i.n.) induced ST2/IL-33R+ ILC2, whilst intramuscular (i.m.) IL-25R+ TSLPR+ (Thymic stromal lymphopoietin protein receptor) ILC2 subsets. However, in muscle a novel ILC subset devoid of known markers (IL-25R− IL-33R− TSLPR−) were found express IL-13, unlike lung. Different vectors also influenced...
Subunit vaccines exhibit favorable safety and immunogenicity profiles can be designed to mimic native antigen structures. However, pairing with an appropriate adjuvant is imperative in order elicit effective humoral cellular immune responses. In this study, we aimed determine optimal the prefusion form of influenza haemagglutinin (HA) or respiratory syncytial virus (RSV) fusion (F) subunit BALB/c mice inform future vaccine selection. We tested a panel adjuvants, including aluminum hydroxide...
No-reference image quality assessment (NR-IQA) is to evaluate the of acquired distorted images by simulating human subjective vision a model. Currently, most NR-IQA methods research shallow features and do not pay attention detail-rich deep features; moreover, information exchange between sub-features extracted from plays an important role in quality-aware features. Therefore, this paper proposes novel, grouping feature-based model, which relies on different levels combined with mechanisms....
Abstract Protein phosphorylation is central to the understanding of multiple cellular signaling pathways responsible for regulating self-renewal and differentiation neural stem cells (NSCs). Here we performed a large-scale phosphoproteomic analysis rat fetal NSCs using strong cation exchange chromatography prefractionation citric acid-assisted two-step enrichment with TiO2 strategy followed by nanoLC-MS/MS analysis. Totally identified 32,546 phosphosites on 5,091 phosphoproteins, among which...
Abstract A HIV vaccine that provides mucosal immunity is urgently needed. We evaluated an intranasal recombinant Fowlpox virus (rFPV) priming followed by intramuscular Modified Vaccinia Ankara (rMVA) booster vaccine, both expressing SIV antigens. The vaccination generated and systemic SIV-specific CD4 + T cell mediated was associated with partial protection against high-dose intrarectal mac251 challenge in outbred pigtail macaques. Three of 12 vaccinees were completely protected these...
Abstract Efforts to develop and deploy effective vaccines against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continue at pace with more than 30 candidate now in clinical evaluation. Here we describe the preclinical development of an adjuvanted, prefusion-stabilised Spike (S) protein “Sclamp” subunit vaccine, from rational antigen design through assessing manufacturability vaccine efficacy. In mice, elicits high levels neutralising antibodies epitopes both within outside...
<title>Abstract</title> Pest detection techniques are helpful in reducing the frequency and scale of pest outbreaks, but their application practical agricultural production processes is still challenging due to problems interspecies similarity, multi-scale background complexity pests. To address above problems, this paper proposes an FD-YOLO target model. The model uses Fully Connected FPN (FC-FPN) instead a PANet neck, which can adaptively fuse features enhance reuse effective features....