A5090943299- Mycobacterium research and diagnosis
- Infectious Diseases and Mycology
- SARS-CoV-2 and COVID-19 Research
- Tuberculosis Research and Epidemiology
- Animal Virus Infections Studies
- Parasitic Infections and Diagnostics
- Forensic Entomology and Diptera Studies
- Viral gastroenteritis research and epidemiology
- Virology and Viral Diseases
- Immunotherapy and Immune Responses
- Infectious Diseases and Tuberculosis
- vaccines and immunoinformatics approaches
- Long-Term Effects of COVID-19
- Neuroinflammation and Neurodegeneration Mechanisms
- Influenza Virus Research Studies
- Bacterial Infections and Vaccines
- Viral Infections and Vectors
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Zoonotic diseases and public health
- Mosquito-borne diseases and control
- Legionella and Acanthamoeba research
- COVID-19 and Mental Health
- Viral Infections and Outbreaks Research
- Inflammasome and immune disorders
Coalition for Epidemic Preparedness Innovations
2023-2025
The University of Queensland
2020-2022
Australian Centre for Disease Preparedness
2020
Commonwealth Scientific and Industrial Research Organisation
2020
The University of Melbourne
2020
Deakin University
2014-2020
Barwon Health
2020
The Royal Melbourne Hospital
2020
Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however, an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe neurological manifestations, including precipitating cases probable Parkinson's disease. As microglial NLRP3 inflammasome activation major driver neurodegeneration, here we interrogated whether promote activation. Using transgenic mice expressing human angiotensin-converting enzyme 2 (hACE2) as COVID-19 pre-clinical model,...
Efforts to develop and deploy effective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue at pace. Here, we describe rational antigen design through manufacturability vaccine efficacy of a prefusion-stabilised spike (S) protein, Sclamp, in combination with the licensed adjuvant MF59 'MF59C.1' (Seqirus, Parkville, Australia).A panel recombinant Sclamp proteins were produced Chinese hamster ovary screened vitro select lead candidate. The structure this was...
Abstract Mycobacterium ulcerans is recognised as the third most common mycobacterial infection worldwide. It causes necrotising infections of skin and soft tissue classified a neglected tropical disease by World Health Organization (WHO). However, despite extensive research, environmental reservoir organism mode transmission to humans remain unknown. This limits ability design implement public health interventions effectively consistently prevent spread reduce incidence this disease. In...
Highlights•The first report of long-term humoral immunity in 25 Nipah virus survivors from 1998 Malaysia.•Anti-NiV-F and anti-NiV-G found 56% 60% survivors, respectively.•At least 72% had detectable neutralizing antibodies.•Six NiV-specific memory B cells.SummaryObjectiveTo evaluate the immune response to (NiV) a cohort after years post-infection.MethodsA total NiV infection outbreak were recruited for sample collection. The serum IgG antibody antigens, specifically nucleocapsid (N), fusion...
Abstract Efforts to develop and deploy effective vaccines against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continue at pace with more than 30 candidate now in clinical evaluation. Here we describe the preclinical development of an adjuvanted, prefusion-stabilised Spike (S) protein “Sclamp” subunit vaccine, from rational antigen design through assessing manufacturability vaccine efficacy. In mice, elicits high levels neutralising antibodies epitopes both within outside...
Prior to 2020, the threat of a novel viral pandemic was omnipresent but largely ignored. Just twelve months prior Coronavirus disease (COVID-19) our team received funding from Coalition for Epidemic Preparedness Innovations (CEPI) establish and validate rapid response pipeline subunit vaccine development based on proprietary Molecular Clamp platform. Throughout course 2019 we conducted two mock tests system antigen production against potential, emerging pathogens, Achimota paramyxovirus...
ABSTRACT Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however, an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe neurological manifestations, including precipitating cases probable Parkinson’s disease. As microglial NLRP3 inflammasome activation major driver neurodegeneration, here we interrogated whether promote utilising model human monocyte-derived microglia. We identified isolates bind and enter microglia, triggering in...
Background: We assessed the safety and immunogenicity of an MF59-adjuvanted subunit vaccine for COVID-19 based on recombinant SARS-CoV-2 spike glycoprotein stabilised in a prefusion conformation by novel molecular clamp (Sclamp).Methods: Phase 1, double-blind, placebo-controlled trial conducted Australia (July 2020–ongoing; ClinicalTrials.gov NCT04495933). Healthy adults (18-55 years) received two doses placebo, 5-μg, 15-μg, or 45-μg Sclamp, one dose Sclamp followed 28 days apart (n=120; 24...
Efforts to develop and deploy effective vaccines against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continue at pace. Here we describe rational antigen design through manufacturability vaccine efficacy, of a prefusion-stabilised Spike (S) protein, Sclamp. This strategy uses an orthogonal stabilisation approach compared canonical vaccines, in combination with the licensed adjuvant MF59 (Seqirus). In mice, Sclamp elicits high levels neutralising antibodies, as well broadly...
Burul ulcer disease is an infection of the subcutaneous layer. The causative organism, Mycobacterium ulcerans a slow-growing environmental pathogen often associated with wetland and slow moving streams. One insect order believed to be M.ulcerans hemiptera, in which aquatic bugs (Naucoris sp Belostoma sp) belong. Some Mycobacteria species are endosymbiont Acanthamoeba laboratory experiments has confirmed this M. endemic area Benin persisting amoeba for 14 days. Aquatic feed on amoeba,...
Burul ulcer disease is an infection of the subcutaneous layer. The causative organism, Mycobacterium ulcerans a slow-growing environmental pathogen often associated with wetland and slow moving streams. One insect order believed to be M.ulcerans hemiptera, in which aquatic bugs (Naucoris sp Belostoma sp) belong. Some Mycobacteria species are endosymbiont Acanthamoeba laboratory experiments has confirmed this M. endemic area Benin persisting amoeba for 14 days. Aquatic feed on amoeba,...
Burul ulcer disease is an infection of the subcutaneous layer. The causative organism, Mycobacterium ulcerans a slow-growing environmental pathogen often associated with wetland and slow moving streams. One insect order believed to be M.ulcerans hemiptera, in which aquatic bugs (Naucoris sp Belostoma sp) belong. Some Mycobacteria species are endosymbiont Acanthamoeba laboratory experiments has confirmed this M. endemic area Benin persisting amoeba for 14 days. Aquatic feed on amoeba,...
Abstract Background Buruli ulcer (BU) is a subcutaneous necrotic infection of the skin caused by Mycobacterium ulcerans . There has been increasing BU incidence in Victoria, Australia. The aim this study to provide an epidemiological update cases Victoria understand pattern distribution over time and space attempt identify local risk factors. Methods A comprehensive descriptive analyses were performed on notification data from 1994 2016. In addition, retrospective temporal, spatial...