A5086700695- Neuroinflammation and Neurodegeneration Mechanisms
- Long-Term Effects of COVID-19
- Mesenchymal stem cell research
- Autophagy in Disease and Therapy
- COVID-19 and Mental Health
- Immune cells in cancer
- IL-33, ST2, and ILC Pathways
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Inflammasome and immune disorders
- Liver Diseases and Immunity
- Fibroblast Growth Factor Research
Yonsei University
2017-2023
The University of Queensland
2022
Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however, an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe neurological manifestations, including precipitating cases probable Parkinson's disease. As microglial NLRP3 inflammasome activation major driver neurodegeneration, here we interrogated whether promote activation. Using transgenic mice expressing human angiotensin-converting enzyme 2 (hACE2) as COVID-19 pre-clinical model,...
ABSTRACT Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however, an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe neurological manifestations, including precipitating cases probable Parkinson’s disease. As microglial NLRP3 inflammasome activation major driver neurodegeneration, here we interrogated whether promote utilising model human monocyte-derived microglia. We identified isolates bind and enter microglia, triggering in...
Fibroblast growth factor (FGF)-2 is one of the most effective factors to increase rate mesenchymal stem cells (MSCs). Previously, we reported that low dose FGF-2 (1 ng/ml) induced proliferation bone marrow-derived (BMSCs) through AKT and ERK activation resulting in reduction autophagy senescence, but not at a high dose. In this study, investigated effects (10 on proliferation, senescence BMSCs for long term cultures (i.e., 2 months). increased dependent manner short (3 days), while during (2...
Background: Activated hepatic stellate cells (HSCs) are closely involved in the initiation, perpetuation, and resolution of liver fibrosis. Pro-inflammatory cytokine levels positively correlated with transition from injury to fibrogenesis contribute HSC pathophysiology Methods: In this study, we investigated effect pro-inflammatory interleukin (IL)-1β on proliferation signaling pathways LX-2 cells, an cell line, using western blotting assays. Results: IL-1β increased rate α-smooth muscle...