A5064320298- Pain Mechanisms and Treatments
- Nitric Oxide and Endothelin Effects
- Pain Management and Treatment
- Herpesvirus Infections and Treatments
- Cancer-related molecular mechanisms research
- Pain Management and Opioid Use
- Healthcare and Venom Research
- Protein Kinase Regulation and GTPase Signaling
- Cancer, Hypoxia, and Metabolism
- Electron Spin Resonance Studies
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Anesthesia and Pain Management
- S100 Proteins and Annexins
- Cholesterol and Lipid Metabolism
- Circular RNAs in diseases
- Pharmacological Effects of Natural Compounds
- Cancer, Stress, Anesthesia, and Immune Response
- Botulinum Toxin and Related Neurological Disorders
- Airway Management and Intubation Techniques
- Anesthesia and Neurotoxicity Research
- Acne and Rosacea Treatments and Effects
- RNA modifications and cancer
- Endometrial and Cervical Cancer Treatments
- Obstructive Sleep Apnea Research
Harbin Medical University
2018-2025
First Affiliated Hospital of Harbin Medical University
2018-2025
Xuzhou Central Hospital
2025
Chengdu University of Technology
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Hangzhou Medical College
2020-2024
Zhejiang Provincial People's Hospital
2019-2024
University of Electronic Science and Technology of China
2024
China Medical University
2012-2024
First Hospital of China Medical University
2010-2024
Rationale: Abnormal metabolic states contribute to a variety of diseases, including cancer. RNA modifications have diverse biological functions and are implicated in cancer development, gastric (GC). However, the direct relationship between glucose homeostasis 4-acetylcytosine (ac4C) modification GC remains unclear. Methods: The prognostic value acetyltransferase NAT10 expression was evaluated human cohort. Additionally, preoperative PET/CT data from patients Micro-PET/CT imaging mice were...
Nuclear factor-erythroid 2-related factor 2 (Nrf2) has been shown to be a negative regulator of osteoclast differentiation, but the precise mechanisms have not yet established. We examined roles Nrf2 in regulating antioxidants and reactive oxygen species (ROS) levels, especially cytoplasmic mitochondrial ROS during osteoclastogenesis vitro. In current study, we found that absence promotes differentiation bone-marrow-derived macrophages (BMMs) RAW 264.7 cells. The receptor activator NF-κB...
Abstract Background Neuropathic pain (NP) is a kind of intractable pain. The pathogenesis NP remains complicated issue for management practitioners. SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2 (SPOCK2) are members the SPOCK family that play significant role in development central nervous system. In this study, we investigated SPOCK2 rat model chronic constriction injury (CCI). Methods Sprague–Dawley rats were randomly grouped to establish CCI models. We examined effects on...
Propofol is one of the most commonly used intravenous anesthetic agents during cancer resection surgery. It can influence proliferation, motility, and invasiveness cells in vitro vivo. However, role propofol lung remains unclear. In this study, we demonstrated effects on proliferation apoptosis cell H460 by using colony formation assay flow cytometry. also decreased tumor size weight established xenografted tumors. Furthermore, propofol-induced endoplasmic reticulum (ER) stress was...
Neuropathic pain is a complex condition that usually lasts lifetime and has major negative impact on life after injury. Improving management an important unmet need. Astaxanthin (AST) natural marine medicine with effective antioxidant anti-inflammatory properties neuroprotective effects. However, few mechanisms can explain the role of AST in treatment neuropathic pain. In present study, we examined its potential to eliminate spinal nerve ligation (SNL) damage by inhibiting phosphorylation...
Neuropathic pain (NP) is chronic and associated with poor effects of general analgesia. It affects patients' health quality life. The apoptotic process lipid peroxidation caused by iron overload called ferroptosis, which may be nervous system disease. A recent study has found that sirtuin 2 (SIRT2) achieves a neuroprotective effect suppressing ferroptosis. Herein, we aimed to examine whether SIRT2 regulated spared nerve injury (SNI)-induced NP ferroptosis in rats. rat model was induced adult...
Previous studies in our laboratory have shown that mixed lineage kinase 3 (MLK3) can be activated following global ischemia. In addition, other laboratories reported the activation of MLK3 may linked to accumulation free radicals. However, mechanism remains incompletely understood. We report here MLK3, overexpressed HEK293 cells, is S-nitrosylated (forming SNO-MLK3) via a reaction with S-nitrosoglutathione, an exogenous nitric oxide (NO) donor, at one critical cysteine residue (Cys-688)....
Trigeminal postherpetic neuralgia is a severe neuropathic pain and often refractory to existing treatment, it develops secondary herpes zoster-infected Gasserian ganglion. Therefore, important prevent the transition of acute/subacute zoster-related trigeminal neuralgia. Despite numerous studies, optimal intervention that reduces incidence still unknown.This study aimed evaluate efficacy safety high-voltage, long-duration pulsed radiofrequency (PRF) on ganglion in patients with...
The mechanisms of NO inhibition CaMK [Ca(2+)/CaM (calmodulin)-dependent protein kinase] II activity were studied. In rat pituitary tumour GH3 cells, TRH [thyrotrophin (TSH)-releasing hormone]-stimulated phosphorylation nNOS [neuronal NOS (NO synthase)] at Ser(847) was sensitive to an inhibitor CaMKs, KN-93, and enhanced by with 7NI (7-nitroindazole). Enzyme CaMKII following in situ treatment also increased. vitro inhibited co-incubation either L-arginine or donors SNAP...
Background: Postherpetic neuralgia (PHN) is often refractory to existing treatments. Treatment of the dorsal root ganglion (DRG) using monopolar pulsed radiofrequency (PRF), which a nonor minimally neurodestructive technique, not efficacious in all patients. Objectives: This study aimed determine safety and clinical efficacy bipolar highvoltage, long-duration PRF on DRG PHN Study Design: Self before-after controlled trial. Setting: Department Pain Medicine, First Affiliated Hospital China...
Background Neurolytic splanchnic nerve block is used to manage pancreatic cancer pain. However, its impact on survival and quality of life remains controversial. The authors’ primary hypothesis was that pain relief would be better with a block. Secondarily, they hypothesized analgesic use, survival, might affected. Methods This randomized, double-blind, parallel-armed trial conducted in five Chinese centers. Eligible patients suffering from moderate severe conditions were randomly assigned...
Xiaowen Lin, Weiqin Zheng, Xiaotong Zhao, Mengyao Zeng, Shibo Li, Sizheng Peng, Tao Song, Yuhui Sun
Post-synaptic density-95 (PSD-95) is a neuronal scaffolding protein that associates with N-methyl-d-aspartate (NMDA) receptors and links them to intracellular signalling molecules. In neurons, nitric oxide synthase (nNOS) binds selectively the second PDZ domain (PDZ2) of PSD-95, thereby exhibiting physiological activation triggered via NMDA receptors. We have demonstrated previously Ca2+/calmodulin-dependent kinase IIα (CaM-K IIα) directly phosphorylates nNOS at residue Ser847, can attenuate...
Obesity is a major risk factor for coronary artery disease, but its impact on anesthetic-induced cardioprotective actions unexplored. We tested whether obesity inhibits anesthetic sevoflurane-induced preconditioning and this effect mediated via the AMP-activated protein kinase (AMPK) signaling pathway. Sprague-Dawley rats were fed high-fat (HF, 45% kcal as fat) or low-fat (LF, 10% diet 12 weeks. HF-fed developed metabolic disturbances including visceral obesity, hyperinsulinemia,...