A5100402873- Microbial Natural Products and Biosynthesis
- RNA modifications and cancer
- Fungal Biology and Applications
- Marine Sponges and Natural Products
- Melanoma and MAPK Pathways
- RNA Research and Splicing
- CAR-T cell therapy research
- Phytochemistry and Biological Activities
- Cancer-related molecular mechanisms research
- Natural product bioactivities and synthesis
- Drug-Induced Adverse Reactions
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Amyloidosis: Diagnosis, Treatment, Outcomes
- interferon and immune responses
- Plant Pathogens and Fungal Diseases
- Cancer Research and Treatments
- Cancer-related gene regulation
- Microbial Community Ecology and Physiology
- HIV Research and Treatment
- Plant and Fungal Species Descriptions
- Medical and Biological Ozone Research
- HIV/AIDS drug development and treatment
- Apelin-related biomedical research
- Immune Cell Function and Interaction
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2024
Shanghai Stomatological Hospital
2024
Capital Medical University
2024
Nanjing Forestry University
2024
Chinese Academy of Medical Sciences Dermatology Hospital
2014-2024
Shanghai Public Health Clinical Center
2024
Wenzhou Medical University
2012-2023
Suizhou Central Hospital
2023
Hubei University of Medicine
2023
Zhejiang University
2022
Circadian rhythms, as physiological systems with self-regulatory functions in living organisms, are controlled by core clock genes and involved tumor development. The protein arginine methyltransferase 6 (PRMT6) serves an oncogene a myriad of solid tumors, including breast cancer. Hence, the primary aim current study is to investigate molecular mechanisms which PRMT6 complex promotes cancer progression. results show that PRMT6, poly(ADP-ribose) polymerase 1 (PARP1), cullin 4 B (CUL4B)-Ring...
Exposure to ultraviolet radiation can lead skin photoaging, which increases the risk of tumors. This study aims investigate how microRNA m
Background: The increasing utilization of interleukin‐17 (IL‐17) monoclonal antibody (MA) for psoriasis treatment, coupled with the high prevalence hepatitis B virus (HBV), underscores need comprehensive safety data. This retrospective study aims to evaluate IL‐17 MA treatment in patients concurrent HBV infection. Research Design and Methods: screened 531 treated MA, ultimately enrolling 59 abnormal serological Outcomes assessed include virological reactivation changes HBsAb serum...
Abstract Tetrapyrrole biosynthesis is an essential and tightly regulated process glutamyl-tRNA reductase (GluTR) a key target for multiple regulatory factors at the post-translational level. By binding to thylakoid membrane protein FLUORESCENT (FLU) or soluble stromal GluTR-binding (GBP), activity of GluTR down- up-regulated. Here, we reconstructed ternary complex composed C-terminal tetratricopepetide-repeat domain FLU, GBP GluTR, crystallized solved structure 3.2 Å. The overall resembles...
Despite decades of study into aortic dissection (AD), a lethal cardiovascular emergency due to tear in the aorta intima or bleeding within wall, leading separation different layers it, factors that influence its progression and deeper regulatory mechanisms remain poorly understood. Nowadays, with maturity N6-methyladenosine (m6A) sequence technology, m6A modification, one type RNA epigenesis, has gradually become new research hotspot for epigenetic molecular regulation. Especially recently,...
Activity-regulated cytoskeleton-associated protein (ARC) is activated by the induction of long-term potentiation and plays an important role in synaptic plasticity memory consolidation. Previous studies have shown that abnormal expression ARC brains patients with Alzheimer's Disease (AD) leads to disturbance plasticity. mainly regulated transcriptional post-translational modification. However, it unclear whether N6-methyladenosine (m6A) engages epigenetic modification ARC. The AlzData...
Proteins containing the Jumonji C (JmjC) domain participated in tumorigenesis and cancer progression. However, mechanisms underlying this effect are still poorly understood. Our objective was to investigate role of AT-rich interaction domain-containing 2 (JARID2) - a JmjC family protein breast cancer, as well its latent association with obesity.Immunohistochemistry, The Cancer Genome Atlas, Gene Expression Omnibus, other databases were used analyze expression JARID2 cells. Growth curve,...
Abstract Background Many studies have indicated that negative emotions and personality traits are related to psoriasis, though few provided causal evidence. Methods Our analysis utilized 15 genome‐wide association study datasets identify instrumental variables associated with emotions, psoriasis vulgaris. Two‐sample Mendelian randomization was conducted the associations of To mitigate bias from multiple tests, we adjusted p ‐values using Benjamini–Hochberg method. Results revealed links...
Background All-trans retinoic acid (ATRA) has been tried for the treatment and prevention of a number epithelial cancers. However, precise mechanism by which ATRA inhibits growth cutaneous squamous cell carcinoma (cSCC) remains elusive. Aims To determine suppressive effects on human cSCC line SCL-1, explore possible mechanisms involved. Methods SCL-1 cells were treated with ATRA, then proliferation was measured 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, while...
Nine new polyoxygenated eremophilane sesquiterpenes, periconianones C–K (1–9), including one unusual isoeremophilane sesquiterpene, periconianone C (1), and four trinor-eremophilane H–K (6–9), were isolated from the endophytic fungus Periconia sp. F-31. Compound 1 is first furan-type reported containing a linkage of C-8/C-11 7,12-epoxy moiety. These compound structures, absolute configurations, elucidated through extensive spectroscopic data analysis, electronic circular dichroism,...
Hyaluronic acid injection is becoming a popular way for penile augmentation. However, only few studies and follow-ups have investigated the various complications of hyaluronic their corresponding management. In this study, total 230 patients who had augmentation with from January 2018 to December 2019 were examined on follow-up girth, complications, At 1-month, 3-month, 6-month postoperative follow-ups, circumference increased by 2.66 ± 1.24 cm, 2.28 1.02 1.80 0.83 respectively. During...
Three new sesquiterpenoids trichoacorenols B–C and cyclonerodiol B (1–3), along with three known ones (4–6), were isolated from the mangrove plant endophytic fungus Trichoderma sp. Xy24 using various column chromatography techniques. The structures of these compounds determined on basis extensive spectroscopic data analyses. Compounds 1, 2, 4, 5 four acorane sesquiterpenes, 3 6 two monocyclic sesquiterpenediols. exhibited significant neural anti-inflammatory activity by inhibiting...
Epimedium is used in traditional Chinese medicine and contains flavonol glycosides that exhibit multiple biological activities. These bioactive usually have a rhamnose moiety at the 3-OH position of prenylflavonols, such as icariin (9), baohuoside I (1a) II (2a). However, to date, no rhamnosyltransferase has been reported catalyze 3-O-rhamnosylation prenylflavonols. In this article, rhamnosyltransferase, EpPF3RT, was identified from E. pseudowushanense B. L. Guo. The recombinant enzyme...
// Min Zhang 1,2,* , Jin 2,* Wensheng Yan 2 and Xinbin Chen 1 College of Life Sciences Technology, Huazhong Agricultural University, Wuhan, China Comparative Oncology Laboratory, Schools Veterinary Medicine Medicine, University California at Davis, CA, USA * These authors have contributted equally to this work Correspondence to: Chen, email: Zhang, Keywords : RPL26, p73, MDM2, eIF4E, protein stability Received April 01, 2016 Accepted October 15, Published November 04, Abstract a p53 family...
A new steroid glucoside (1), along with nine known steroids (2-10) and four sorbicillinoids (11-14), were isolated from the endophytic fungus Trichoderma sp. Xy24. Their structures elucidated on basis of spectroscopic data analyses by comparison reported data. Compounds 3, 5-7, 9, 10, 13 exhibited significant inhibitory effects HIV-1 virus IC50 values ranging 1.9-9.3 μM; compounds 13, 14 showed potent activity LPS-induced NO production in BV2 microglia cells rates 108.2, 100, 75.1% at 10 μM,...