A5101831107- Cancer, Lipids, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- RNA Research and Splicing
- Inflammatory Biomarkers in Disease Prognosis
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Biomarkers in Disease Mechanisms
- Connective Tissue Growth Factor Research
- Cancer, Stress, Anesthesia, and Immune Response
- Pancreatic and Hepatic Oncology Research
- Cancer Mechanisms and Therapy
- Adipokines, Inflammation, and Metabolic Diseases
- Nosocomial Infections in ICU
- Mechanical Circulatory Support Devices
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Heart Failure Treatment and Management
- MicroRNA in disease regulation
- PARP inhibition in cancer therapy
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related gene regulation
University of Science and Technology of China
2016-2023
Liaoning Cancer Hospital & Institute
2021-2022
China Medical University
2022
Cancer Institute (WIA)
2021
Nankai University
2019-2020
Chinese PLA General Hospital
2019
Chinese People's Liberation Army
2019
Ziopharm Oncology (United States)
2016
Vanderbilt University
2013
MicroRNAs (miRNAs) typically bind to unstructured miRNA-binding sites in target RNAs, leading a mutual repression of expression. Here, we report that miR-1254 interacts with structured elements cell cycle and apoptosis regulator 1 (CCAR1) 5' untranslated region (UTR) this interaction enhances the stability both molecules. can also act as repressor when binding its targets. Interestingly, miR-1254-targeting functional RNA motif-sensing unit, an independent unit Artificially designed miRNA...
Although DNA damage repair plays a critical role in cancer chemotherapy, the function of lncRNAs this process remains largely unclear. In study, silico screening identified H19 as an lncRNA that potentially response and sensitivity to PARP inhibitors. Increased expression is correlated with disease progression poor prognosis breast cancer. cells, forced promotes resistance inhibition, whereas depletion diminishes increases exerted its functional roles via direct interaction ILF2 cell...
Chronic inflammation has been implicated in the pathogenesis of colorectal cancer. The objective this study was to evaluate association prediagnostic circulating levels C-reactive protein (CRP), a biomarker systemic inflammation, with subsequent development Prediagnostic plasma CRP were examined among 288 cancer cases and 576 individually-matched controls nested within Shanghai Men's Health Study (2002-06), population-based cohort 61 482 Chinese men. between risk investigated. Baseline 53%...
This study aimed to assess the potential relationship between tumor mutation burden (TMB) and recurrence risk of hepatocellular cancer (HCC) after curative resection tried develop a reliable TMB based nomogram.This retrospective was conducted in 128 patients (40 suffered from HCC) who had received radical hepatectomy by same surgical team. A nomogram model constructed using R EmpowerStats software.TMB not associated with maximum size presence microvascular invasion (MVI). In whole population...
As we all know, curative resection remains the only effective treatment for hepatocellular cancer (HCC). However, systemic inflammatory response syndrome always correlates with surgery, which may impose an impact on clinical outcome of HCC patients who had undergone treatment. The present study is aimed at exploring correlation between perioperative mediators and recurrence risk HCC. This retrospectively included 157 histologically confirmed single (88 developed again) received radical...
This study was to examine the association between treatment with angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) and risk of developing ventilator-associated pneumonia (VAP) among patients receiving mechanical ventilation (MV) in intensive care unit (ICU). Utilizing a retrospective cohort approach, data were extracted from Medical Information Mart for Intensive Care IV database. VAP diagnoses ascertained through international classification disease...
BACKGROUND Matricellular proteins of the extracellular matrix (ECM) include tenascin-C (TNC) and cellular communication network factor 3 (CCN3). This study aimed to investigate role TNC CCN3 as prognostic factors for post hepatectomy liver failure (PHLF) in a rat model partial 50 patients following hepatectomy. MATERIAL AND METHODS Sprague-Dawley rats underwent 85% (n=53) or 90% (PHx) model. mRNA expression residual tissue was evaluated using quantitative reverse transcription-polymerase...
The objective of this study was to explore the potential relationship between tumor abnormal protein (TAP) and prognosis hepatocellular carcinoma (HCC) after a radical hepatectomy.This retrospective included 168 HCC patients (tumor recurrence in 78 patients) who underwent curative resection from January 2018 June 2020. whole population categorized into TAP high (≥224.6 μm2) or low group (<224.6 μm2).There no correlation maximum size TAP. In subgroups stratified by size, recurrence-free...
Objective To analyze the impact of Pringle’s maneuver on postoperative serum inflammatory mediator levels and prognosis in hepatitis B virus-related hepatocellular carcinoma (HBV related HCC) patients. Methods A retrospective study was conducted 157 HBV HCC patients who underwent treatment at Chinese PLA General Hospital from January 2016 to December 2017. There were 128 males 29 females. The mean age (54.5±12.1) years. These divided into 106 (the group). remaining Occlusion-free...
患者女性，2018年2月8日于解放军总医院第一医学中心诊断为Ⅳ期肝内胆管细胞癌。2018年3月－10月连续接受15次程序性死亡受体1(PD-1)抗体治疗及右肝主病灶放射治疗，连续治疗7个月后，患者的右肝病灶大小及血供较前明显减少，肝门区及腹膜后转移淋巴结较前明显缩小。2018年10月－2019年4月，患者先后接受阿帕替尼(apatinib)及仑伐替尼(lenvatinib)维持治疗。2019年4月，根据修订的实体瘤疗效评价标准，该患者的疗效评价至少为部分缓解。临床上完成降期，从Ⅳ期降为Ⅱ期。2019年4月16日，该患者接受肝右后叶切除术及肝周、腹膜后原病灶清除术，手术顺利，于术后7日无并发症出院。
Abstract Background: TAP (tumor abnormal protein) has been used as an important indicator in the early diagnosis of cancers, and some literatures showed that can act a prognostic factor different kinds cancer. The objective this study was to explore potential relationship between prognosis HCC after radical hepatectomy, attempted construct robustly predictive nomogram on strength other variables patients.Methods: This retrospective included 168 patients recurrence occurred 78 patients) who...