A5101845697- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Single-cell and spatial transcriptomics
- Esophageal and GI Pathology
- Medical Research and Treatments
- Cancer Genomics and Diagnostics
- Pneumocystis jirovecii pneumonia detection and treatment
- Enhanced Recovery After Surgery
- Ferroptosis and cancer prognosis
- Anesthesia and Pain Management
- Transplantation: Methods and Outcomes
- Immune cells in cancer
- Liver physiology and pathology
- Nausea and vomiting management
- Cancer, Lipids, and Metabolism
- Esophageal Cancer Research and Treatment
- Tracheal and airway disorders
- Antifungal resistance and susceptibility
Chinese People's Liberation Army
2023-2025
Chinese PLA General Hospital
2017-2024
People's Liberation Army No. 150 Hospital
2023
PLA Academy of Military Science
2019
Beijing YouAn Hospital
2009
Abstract Hepatocellular carcinoma (HCC) represents a paradigm of the relation between tumor microenvironment (TME) and development. Here, we generate single-cell atlas multicellular ecosystem HCC from four tissue sites. We show enrichment central memory T cells (T CM ) in early tertiary lymphoid structures (E-TLSs) assess relationships chronic HBV/HCV infection cell infiltration exhaustion. find MMP9 + macrophages to be terminally differentiated tumor-associated (TAMs) PPARγ pivotal...
Background & Aims: Only a minority of patients could benefit from systemic therapy owing to the high heterogeneity HCC. Therefore, deeper understanding pathogenesis HCC is essential for precision therapy. Genomic and proteomic studies have enhanced our However, phosphoproteomic characterization remains poorly understood. Approach Results: We conducted an in-depth analysis clinical cohort using high-coverage phosphoproteomic. Effective therapeutic targets were validated liver cancer cell...
The aim of this study was to investigate the prognostic factors influencing outcome patients with Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma (HCC) receiving salvage surgery after conversion therapy based on tyrosine kinase inhibitors (TKIs) and anti-programmed death-1 (PD-1) antibodies.From June 2018 December 2022, PD-1 TKIs at Faculty Hepato-Pancreato-Biliary Surgery, Chinese PLA General Hospital were retrospectively recruited for study. Overall survival (OS)...
Objective To summarize and investigate the incidence, reason, dignosis treatment of postoperative early cardiovascular complication after orthotopic liver transplantation(OLT).Methods A retrospective study was made for diagnosis 2 weeks following OLT.Results In 121 patients receiving OLT, compli-cation developed in 30 (24.8%).The complications were hypertension 11 (9.1%), heart failure 9 (7.4 %), isehemie disease 7 (5.8%) cardiac arrhythmia 12 (9.9 %).The mortality OLT related to 3.3 % (4...
Objective To introduce the suture method of upper mediastinum in thoracoscopic radical resection esophageal carcinoma, and to evaluate feasibility necessity technique. Methods A total 248 patients undergoing esophagectomy were retrospectively included this study from Jul. 2015 Jun. 2017 Department Cardithoracic Surgery Northern Jiangsu People′s Hospital. 245 underwent mediastinal suture. Summarize analyze incidence intraoperative bleeding, volvulus tubular stomach, postoperative...
Objective To investigate the difference of hepatic microvessel density, neovascularization regenerating liver tissue after ablation two ways irreversible electroporation and radiofrequency in rats. Methods 90 male Sprague-Dawley rats were randomly divided into 3 groups, including control group (n=30), (n=30) (n=30). 3, 7 10 days executed operation draw material, expression vascular endothelial growth factor(VEGF) CD34 was studied by immunohistochemistry, microvascular density VEGF...