A5088277540- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- vaccines and immunoinformatics approaches
- Medicinal Plant Pharmacodynamics Research
- Cytokine Signaling Pathways and Interactions
- IL-33, ST2, and ILC Pathways
- Single-cell and spatial transcriptomics
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- RNA Research and Splicing
Chinese PLA General Hospital
2024
Chinese People's Liberation Army
2018
Cadherin-6 (CDH6) is aberrantly expressed in cancer and closely associated with tumor progression. However, the functions of CDH6 human osteosarcoma molecular mechanisms underlying oncogenesis remain poorly understood. In this work, we assessed role identified that expression was related overall survival poor prognosis patients. MicroRNAs (miRNAs) have been implicated as important epigenetic regulators during progression osteosarcoma. Using dual-luciferase reporter assays, showed miR-223-3p...
Objective To investigate the antitumor effect of natural killer (NK) cells on human colorectal cancer HT-29 in vitro by blocking transforming growth factor-β (TGF-β) signaling NK transfected with vector containing dominant negative TGF-β type 2 receptor (DNTβR2). Methods TGF-β1 was added at final concentration 10 ng/ml for cells. Primary were recombinant plasmid pIRES2-AcGFP-DNTβR2 and control pIRES2-AcGFP using Amaxa Nucleofector technology respectively. The cytotoxicity these two types to...