A5081648337- Salivary Gland Disorders and Functions
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Gastrointestinal Bleeding Diagnosis and Treatment
- Natural product bioactivities and synthesis
- Oral Health Pathology and Treatment
- IgG4-Related and Inflammatory Diseases
- MicroRNA in disease regulation
- NF-κB Signaling Pathways
- Pharmacological Effects of Natural Compounds
- Growth Hormone and Insulin-like Growth Factors
- Cholesterol and Lipid Metabolism
- 3D Printing in Biomedical Research
- interferon and immune responses
- Gastrointestinal disorders and treatments
- Dental Erosion and Treatment
- Pluripotent Stem Cells Research
- Systemic Lupus Erythematosus Research
- RNA Research and Splicing
- Dental Health and Care Utilization
- Immune Cell Function and Interaction
- Oral microbiology and periodontitis research
- Polysaccharides and Plant Cell Walls
- Lipid metabolism and disorders
- Pancreatic function and diabetes
Shanghai Ninth People's Hospital
2016-2024
Shanghai Jiao Tong University
2016-2024
Shanghai Stomatological Hospital
2023
Shanghai East Hospital
2023
National Clinical Research Center for Digestive Diseases
2019-2022
Shandong University
2018
Objective: To assess the efficacy and safety of an oral mucoadhesive film containing chitosan for treatment recurrent aphthous stomatitis (RAS).Methods: Seventy-two subjects with RAS were recruited to this randomized, parallel-controlled, double-blind clinical trial. The participants randomly allocated test group or control group. Demographic data recorded at baseline. use was demonstrated. Pain score (visual analog scale), adverse effects, ulcer size on day 1 (baseline), 2, 4, 6.Results:...
Circular RNAs (circRNAs) are involved in the pathogenesis of several diseases. Among oral maxillofacial cancers, squamous cell carcinoma (OSCC) has highest incidence. However, role circRNAs OSCC is still not clear. The aim our study was to evaluate circRNA expression profile and explore further potential OSCC.CircRNA sequencing performed 6 pairs samples normal mucosal tissues. Expression selected validated by qRT-PCR. GO KEGG analyses were binding relationships between miRNAs predicted....
Previous studies have shown that abnormal metabolic reprogramming in CD4+ T cells could explain the occurrence of several autoimmune disorders, including Sjogren's syndrome (SS). However, therapeutic targets metabolism remain to be explored. Here, we report glutaminase 1 (Gls1), a pivotal factor glutaminolysis, might involved pathogenesis SS. The expression Gls1 was upregulated infiltrated labial and circulating SS patients. Inhibiting with BPTES significantly abolished proliferation rate,...
Fangchinoline (Fan) is extracted from traditional Chinese medicine (called Fangji), or the root of Stephania tetrandra Moore. Fangji well-known in medical literature for treating rheumatic diseases. Sjogren's syndrome (SS) a disease whose progression can be mediated via CD4+ T cell infiltration.This study identifies potential role Fan inducing apoptosis Jurkat cells.First, we explored biological process (BP) associated with SS development by performing gene ontology analysis salivary...
Introduction: Sjögren's syndrome (SS) is a chronic autoimmune disorder characterized by exocrine gland dysfunction, leading to loss of salivary function. Histological analysis glands from SS patients reveals high infiltration immune cells, particularly activated CD4+ T cells. Thus, interventions targeting abnormal activation cells may provide promising therapeutic strategies for SS. Here, we demonstrate that Hect, uba, and wwe domain containing 1 (HUWE1), member the eukaryotic Hect E3...
Abstract Objective The study aimed to establish an effective back‐Propagation artificial neural network (BP‐ANN) model for automatic prediction of 3‐month treatment outcome IgG4‐DS. Methods A total 26 IgG4‐DS patients at Shanghai Ninth People's Hospital from January 2018 December 2019 were involved in the study. They all followed >3 months. primary was reduction serum IgG4 (sIgG4) after treatment. association between risk factors and sIgG4 analyzed by Spearman's rank correlation test....
To investigate the clinical significance of differentially expressed circRNAs and candidate in transformation oral leukoplakia (OLK) to squamous cell carcinoma (OSCC). We performed high-throughput circRNA sequencing six cases normal mucosal (NOM) tissues, OLK OSCC tissues. Ten with significant differential expression were verified by qRT-PCR. Enzyme tolerance assay Sanger on screened target hsa_circ_0060927, a qRT-PCR hsa_circ_0060927 was three tissues (24 each group); this followed an ROC...
Backgound: Fangchinoline is a bisbenzylisoquinoline alkaloid extracted from Stephania tetrandra S. Moore that conventionally used as an analgesic, antirheumatic, and antihypertensive drug in China. However, the application of Fanchinoline Sjögren syndrome (SS) remains unreported. Objective: This study aimed to identify potential role treatment SS via altering Akt/mTOR signaling. Methods: First, we examined levels p-Akt p-mTOR infiltrating lymphocytes labial glands patients by...
Background: This study sought to identify the circular RNAs (circRNAs) differentially expressed in oral lichen planus (OLP) investigate possible role of circRNAs this disease's pathogenesis.
Emerging evidence indicates that circular RNAs (circRNAs) play an indispensable role in a variety of tumors, yet the function circRNAs premalignant lesions is still obscure. Oral leukoplakia (OLK) one most common oral mucosa. Our study aimed to comprehensively investigate whether contribute occurrence and development OLK.We obtained six pairs OLK normal mucosal (NOM) tissue samples subjected them high-throughput sequencing detect expression circRNA. In total, 26 NOM tissues were used for...
The treatment of oral mucosa defect such as autologous caused by resection carcinoma is still not ideal in clinical practice. However, Tissue engineering gives us the possibility to solve this problem. As we all know, Human embryonic stem cells (hESCs) have ability give rise various cell types. We can take advantage totipotency human acquire keratinocytes. Directing epithelial differentiation hESCs provide seed for construction epithelium tissue engineering. But, how get high purity...
Fangji Huangqi Tang (FHT) is a well-known Chinese herbal formula that prescribed as treatment for rheumatoid diseases. In this study, we aimed to investigate the potential therapeutic targets, efficacy, and safety of FHT in Sjogren's syndrome (SS). The Gene Expression Omnibus (GEO) database was used screen differentially expressed genes (DEGs) SS. Further, gene ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analyses were performed explore biological functions DEGs....