Jingfang Gao
A5051273697- Microbial Metabolic Engineering and Bioproduction
- Fungal and yeast genetics research
- Maternal Mental Health During Pregnancy and Postpartum
- Chromium effects and bioremediation
- Genetic factors in colorectal cancer
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Child and Adolescent Psychosocial and Emotional Development
- Tryptophan and brain disorders
- Plant nutrient uptake and metabolism
- Treatment of Major Depression
- Stress Responses and Cortisol
- Mental Health Research Topics
- Colorectal Cancer Treatments and Studies
- Cancer Cells and Metastasis
- Algal biology and biofuel production
- TGF-β signaling in diseases
- Suicide and Self-Harm Studies
- NF-κB Signaling Pathways
- Peptidase Inhibition and Analysis
- Attachment and Relationship Dynamics
- Genetic Associations and Epidemiology
- DNA Repair Mechanisms
- Mental Health Treatment and Access
- Biofuel production and bioconversion
- Employment and Welfare Studies
Zhejiang Chinese Medical University
2012-2025
Linköping University
2005-2020
Zhejiang University
2019
Tianjin Institute of Industrial Biotechnology
2017
Chinese Academy of Sciences
2017
Heilongjiang University
2017
Hangzhou Hospital of Traditional Chinese Medicine
2009-2015
Zhejiang Provincial Hospital of TCM
2015
University of Gothenburg
2010-2014
Harbin Medical University
2003-2010
Adversity, particularly in early life, can cause illness. Clues to the responsible mechanisms may lie with discovery of molecular signatures stress, some which include alterations an individual's somatic genome. Here, using genome sequences from 11,670 women, we observed a highly significant association between stress-related disease, major depression, and amount mtDNA (p = 9.00 × 10(-42), odds ratio 1.33 [95% confidence interval [CI] 1.29-1.37]) telomere length 2.84 10(-14), 0.85 CI...
Most of the previous studies have demonstrated potential antidepressive and anxiolytic role prebiotic supplement in male subjects, yet few females enrolled. Herein, we explored whether prebiotics administration during chronic stress prevented depression-like anxiety-like behavior a sex-specific manner mechanism behavioral differences caused by sex.
Abstract Purpose: Legumain, a novel asparaginyl endopeptidase, has been observed to be highly expressed in several types of tumors including colorectal cancer. However, there is no study examining the relationship legumain expression clinocopathologic and biological variables cancers. Experimental Design: We investigated 164 primary cancers, 34 corresponding distant normal mucosa samples, 89 adjacent 33 lymph node metastases using immunohistochemistry. also did Western blotting analysis on...
Transforming growth factor beta (TGF-β) plays major roles in tumorigenesis by regulating cell growth, epithelial-to-mesenchymal transition (EMT), migration/invasion and metastasis. The epithelial markers E-cadherin, claudin-3 claudin-4, commonly decreased human adenocarcinomas are actually up regulated during ovarian carcinogenesis. In cancer TGF-β1 may either suppress or promote tumor progression, but whether other TGF-β isoforms (TGF-β2 TGF-β3) exert similar effects is not known.In this...
The glucose dual-affinity transport system (low- and high-affinity) is a conserved strategy used by microorganisms to cope with natural fluctuations in nutrient availability the environment. glucose-sensing uptake processes are believed be tightly associated cellulase expression regulation cellulolytic fungi. However, both identities functions of major molecular components this evolutionarily filamentous fungi remain elusive. Here, we systematically identified characterized model fungus...
Background. Despite substantial research, uncertainty remains about the clinical and etiological heterogeneity of major depression (MD). Can meaningful valid subtypes be identified would they stable cross-culturally? Method. Symptoms at their lifetime worst depressive episode were assessed structured psychiatric interview in 6008 women Han Chinese descent, age ⩾30 years, with recurrent DSM-IV MD. Latent class analysis (LCA) was performed Mplus. Results. Using nine MD symptomatic A criteria,...
Background The symptoms of major depression (MD) are clinically diverse. Do they form coherent factors that might clarify the underlying nature this important psychiatric syndrome? Method Symptoms at lifetime worst depressive episode were assessed structured interview in 6008 women Han Chinese descent, age ⩾30 years with recurrent DSM-IV MD. Exploratory factor analysis (EFA) and confirmatoryfactor (CFA) performed Mplus random split-half samples. Results preliminary EFA results consistently...
Background Our prior study in Han Chinese women has shown that with a history of childhood sexual abuse (CSA) are at increased risk for developing major depression (MD). Would this relationship be found our whole data set? Method Three levels CSA (non-genital, genital, and intercourse) were assessed by self-report two groups women: 6017 clinically ascertained recurrent MD 5983 matched controls. Diagnostic other factor information was personal interview. Odds ratios (ORs) calculated logistic...
Background The prevalence of major depressive disorder (MDD) is higher in those with low levels educational attainment, the unemployed and social status. However extent to which these factors cause MDD unclear. Most available data comes from studies developed countries, findings may not extrapolate developing countries. Examining relationship between socio economic status China likely add debate because radical changes occurring over last 30 years. Principal We report results 3,639 Chinese...
Objective. An insertion/deletion polymorphism (−94ins/delATTG) in the promoter region of NFKB1 gene correlates to an increased risk ulcerative colitis, a known factor for colorectal cancer, but this has not been studied cancer patients. The purpose study was investigate whether is related and clinicopathological variables. Material methods. Case samples were taken from four groups Swedish patients: 193 unselected patients, 90 patients with ≥3 affected 1st-degree relatives, 85 2 109 sporadic...
In Western countries, a history of major depression (MD) is associated with reports received parenting that low in warmth and caring high control authoritarianism. Does similar pattern exist women China?Received was assessed by shortened version the Parental Bonding Instrument (PBI) two groups Han Chinese women: 1970 clinically ascertained cases recurrent MD 2597 matched controls. at personal interview.Factor analysis PBI revealed three factors for both mothers fathers: warmth,...
In European and US studies, patients with major depressive disorder (MDD) report more stressful life events (SLEs) than controls, but this relationship has rarely been studied in Chinese populations. Sixteen lifetime SLEs were assessed at interview two groups of Han women: 1970 clinically ascertained recurrent MDD 2597 matched controls. Diagnostic other risk factor information was personal interview. Odds ratios (ORs) calculated by logistic regression. 60% controls 72% cases reported least...
Background Adolescence is a period of high incidence for depression. However, there limited treatment option the adolescent For treatment-resistant major depressive disorder, HF-rTMS left dorsolateral prefrontal cortex (DLPFC) appears therapeutically effective. The aim study to explore early effects repetitive transcranial magnetic stimulation in combination with sertraline adolescents first-episode disorder. Methods A total 100 teenage patients depression were randomly divided into groups....
Depression is associated with a high incidence of stressful life events (SLEs) and neuroticism. However, the impact SLEs neuroticism on recurrence major depressive disorder (MDD) remains unclear. Therefore, we aimed to identify potential causal relationship between SLEs, neuroticism, depression recurrence. This study included 5561 female patients recurrent MDD (ages 30-60) 4257 healthy volunteers 40-60) from China, Oxford, Virginia Commonwealth University Experimental Research Genetic...
Objective. The inhibitory proteins, IκBs, regulate the activity of nuclear factor kappa-beta (NF-κB), which is implicated in tumorigenesis by regulating expression a variety genes involved cellular transformation, proliferation, invasion, angiogenesis and metastasis. Variants encoding IκBs may be cancer development through activation NF-κB. objective this study was to investigate susceptibility an A G variation (rs696) 3′ UTR NFKBIA (encoding IκBα) colorectal (CRC) association polymorphism...
Studies conducted in Europe and the USA have shown that co-morbidity between major depressive disorder (MDD) anxiety disorders is associated with various MDD-related features, including clinical symptoms, degree of familial aggregation socio-economic status. However, few studies investigated whether these patterns association vary across different co-morbid disorders. Here, using a large cohort Chinese women recurrent MDD, we examine prevalence features disorders.A total 1970 female MDD...
The relationship between suicidality and major depression is complex. Socio- demography, clinical features, comorbidity, symptoms, stressful life events are important factors influencing suicide in depression, but these not well defined. Thus, the aim of present study was to assess associations above-mentioned ideation, plan, attempt 6008 Han Chinese women with recurrent (MD). Patients any had significantly more MD a greater number events, positive family history MD, episodes, significant...
To observe the effect of soothing-liver and nourishing-heart acupuncture on selective serotonin reuptake inhibitor (SSRIs) treatment onset in patients with depressive disorder related indicators neuroimmunology. Overall, 126 were randomly divided into a medicine acupuncture-medicine group using random number table. Patients treated for 6 consecutive weeks. The two groups evaluated by Montgomery-Asberg Depression Rating Scale (MADRS) Side Effects (SERS) to assess method early SSRI effect....
AIM:The relationships between microsatellite instability (MSI) and survival in colorectal cancer patients are not consistent.The favorable of patient with MSI has been suggested to be related pronounced inflammatory infiltration; however, the reason for non-association is unclear.Our aims were investigate associations infiltration tumor necrosis (TN) status clinicopathological factors whom was survival. METHODS:Three hundred one adenocarcinomas evaluated 300 TN under light microscope....
RAD50/MRE11/NBS1 complex is essential for DNA double-strand break repair and maintaining genomic integrity. In this study, we immunohistochemically examined MRE11, NBS1 RAD50 expression in primary CRCs (n=208), the corresponding distant (n=41) adjacent normal mucosa (n=130), lymph node metastases (n=26), investigated their clinicopathological significance colorectal cancers (CRCs). We found that intensity percentage of MRE11 were positively correlated with each other (P<0.0001). Strong or...
Background The relationship between recurrent major depression (MD) in women and suicidality is complex. We investigated the extent to which patients who suffered with various forms of suicidal symptomatology can be distinguished from those subjects without such symptoms. Method examined clinical features worst episode 1970 Han Chinese DSM-IV MD ages 30 60 years across China. Student's t tests, logistic multiple regression models were used determine association other MD. Results Suicidal...