A5051526380- Tryptophan and brain disorders
- MicroRNA in disease regulation
- Neurogenesis and neuroplasticity mechanisms
- Treatment of Major Depression
- Schizophrenia research and treatment
- Stress Responses and Cortisol
- Sleep and related disorders
- Suicide and Self-Harm Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Acupuncture Treatment Research Studies
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Bipolar Disorder and Treatment
- Bone health and treatments
- Parkinson's Disease Mechanisms and Treatments
- RNA regulation and disease
- Genetics, Aging, and Longevity in Model Organisms
- Eating Disorders and Behaviors
- Obsessive-Compulsive Spectrum Disorders
- Neurological diseases and metabolism
- Vitamin D Research Studies
- Neurological disorders and treatments
- Transcranial Magnetic Stimulation Studies
- Genetics and Neurodevelopmental Disorders
- 14-3-3 protein interactions
Zhejiang University
2018-2025
Hangzhou Seventh Peoples Hospital
2015-2025
Anhui Medical University
2025
Lu'an First People's Hospital
2025
Third Hospital of Hebei Medical University
2023-2024
Hebei Medical University
2023-2024
Zhejiang Chinese Medical University
2017-2020
Hangzhou Hospital of Traditional Chinese Medicine
2020
Parkinson's disease (PD) is a common neurodegenerative disorder. Iron metabolism abnormalities have been reported in PD patients and may contribute to pathogenesis. Our study aimed explore key genes associated with iron patients. Three datasets metabolism-related (IMRGs) were collected from the public database, merged into combined dataset. PD-related differentially expressed (DEGs) obtained intersected IMRGs acquire DEGs (IMRDEGs). Subsequently, IMRDEGs subjected functional enrichment ROC...
To observe the effect of soothing-liver and nourishing-heart acupuncture on selective serotonin reuptake inhibitor (SSRIs) treatment onset in patients with depressive disorder related indicators neuroimmunology. Overall, 126 were randomly divided into a medicine acupuncture-medicine group using random number table. Patients treated for 6 consecutive weeks. The two groups evaluated by Montgomery-Asberg Depression Rating Scale (MADRS) Side Effects (SERS) to assess method early SSRI effect....
Melatonin is a hormone synthesized and secreted by the pineal gland with effect of regulating sleep rhythm. Circadian disturbances may be central for understanding pathophysiology treatment depression. Recently, melatonergic system has been implicated in In this study, we observed effects melatonin on depression-like behavior induced chronic unpredictable mild stress (CUMS) rats, its molecular mechanism was explored. Adult male Sprague–Dawley rats were exposed to CUMS 4 weeks. or saline...
Abstract Valproic acid is an anticonvulsant, which also widely used for treating psychiatric disorders. Some clinical trials have demonstrated benefits of valproic augmentation therapy in schizophrenia. Interindividual variability dose and serum concentration may reflect functional consequences genetic polymorphisms genes encoding drug-metabolizing enzymes. The aim this study was to determine the relationship between concentrations single nucleotide cytochrome P450 (CYP) 2C19 gene patients...
Chronic insomnia is a major public health problem, but there are limited effective therapies. Jiawei Suanzaoren Decoction (JW-SZRD) has been used as an alternative option for treating insomnia. This study aimed to investigate the long-term efficacy and safety of JW-SZRD in combination with lorazepam chronic insomnia.A total 207 participants were analyzed this study. The treatment group (TG) received orally, control (CG) alone. Insomnia Severity Index (ISI), Self-Rating Depression Scale...
Background. Paroxetine does not show satisfactory therapeutic effect for generalized anxiety disorder (GAD) patients the first 2-4 weeks of medication. Diazepam is always concurrently used although it has some shortcomings such as physical dependence and withdrawal reactions. In this study, we aimed to identify whether modified Suanzaorentang (MSZRT), a combined Chinese formula including (SZRT) Zhizichitang (ZZCT), could control GAD 4 paroxetine Methods. 156 were randomized treatment...
Objective To investigate the expression levels of miRNA132 in patients with first-episode major depressive disorder(MDD) and chronic unpredictable mild stress(CUMS)rats.Methods Forty-one MDD patients(MDD group)were recruited from outpatient departments Hangzhou Seventh People's Hospital between March 2017 May 2018,and 31 healthy volunteers(control recruited.The patients' severity symptoms was assessed HAMD17.In addition,24 male SD rats were equally assigned into control group CUMS group.The...
Systemic treatment, including molecular targeted therapy, immunotherapy, and chemotherapy, is an important means of achieving long-term survival in patients with intermediate-and advanced-stage liver cancer. However, some are insensitive to treatment even develop drug resistance. Mitochondria the center cellular energy metabolism and, at same time, priority targets for systemic therapy. Mitochondrial homeostasis plays role The relationship between two advances elucidated so as provide better...
The effectiveness of medication combined with smartphone-delivered cognitive behavioral therapy for insomnia (CBT-I) has been well verified, but there are few studies on the sequence remission symptoms. This study aims to understand symptom improvement and factors influencing treatment in patients insomnia.
Molecular targeted drugs are one of the treatments for hepatocellular carcinoma (HCC), primary factor influencing their therapeutic efficacy is drug resistance. Diminished intake, greater efflux, improved DNA damage repair capacity, aberrant signal pathways, hypoxia, epithelial-mesenchymal cell transition, and cellular autophagy system summarized herein as aspects resistance mechanism. Simultaneously, effective strategies addressing elaborated, providing ideas better clinical treatment...
Objective To study the expression of miRNA-219 and γCaMK Ⅱ mRNA in peripheral blood first-episode major depressive disorder (MDD) patients, explore relationship between these molecular level MDD symptom. Methods Fourty-one patients diagnosed with DSM-5 criteria 31 healty volunteers were included. The was collected fasting state levels γCaMKⅡ detected. patients′ severity symptoms assessed HAMD17. Real-time PCR used to detect leukocytes. correlation miRNA-219, HAMD17...