A5001723162- Nanoplatforms for cancer theranostics
- Nanoparticles: synthesis and applications
- Carbon and Quantum Dots Applications
- Advanced Nanomaterials in Catalysis
- Selenium in Biological Systems
- Graphene and Nanomaterials Applications
- AI in cancer detection
- Nanocluster Synthesis and Applications
- Luminescence and Fluorescent Materials
- Alzheimer's disease research and treatments
- Nanoparticle-Based Drug Delivery
- Postharvest Quality and Shelf Life Management
- Photochromic and Fluorescence Chemistry
- Antimicrobial agents and applications
- Cardiac Ischemia and Reperfusion
- Electrospun Nanofibers in Biomedical Applications
- Phenothiazines and Benzothiazines Synthesis and Activities
- Antibiotic Resistance in Bacteria
- Pharmaceutical and Antibiotic Environmental Impacts
- Radiomics and Machine Learning in Medical Imaging
- Advanced Photocatalysis Techniques
- Bacterial biofilms and quorum sensing
- Photoacoustic and Ultrasonic Imaging
- Tree Root and Stability Studies
- Digital Imaging for Blood Diseases
Anhui Agricultural University
2015-2025
First Affiliated Hospital of Wannan Medical College
2025
Hefei University of Technology
2024-2025
Wuhan University of Science and Technology
2024
Henan Agricultural University
2024
Nanjing University of Chinese Medicine
2022-2024
South China University of Technology
2023
Hefei University
2020
Jinan University
2012-2015
Chongqing University
2012
Abstract Irreversible bacterial resistance and impenetrable biofilms have rendered conventional antibiotic therapy ineffective. Nevertheless, increasing evidence has confirmed that carbon nanodots (CDs) exhibit potent antibacterial activity. However, the complex chemical composition of CDs, and, hence, their mechanism, is difficult to understand. The design new CDs against an urgent requirement.In this study, kanamycin‐sulfate‐derived (KCDs) are found significant potential with assistance...
Abstract Cardiovascular disease is the leading cause of death worldwide. Reperfusion therapy vital to patient survival after a heart attack but can myocardial ischemia/reperfusion injury (MI/RI). Nitric oxide (NO) ameliorate MI/RI and key molecule for drug development. However, reactive oxygen species (ROS) easily oxidize NO peroxynitrite, which causes secondary cardiomyocyte damage. Herein, L‐arginine‐loaded selenium‐coated gold nanocages (AAS) are designed, synthesized, modified with PCM...
Alzheimer's disease (AD), the most common neurodegenerative disease, is caused by an accumulation of amyloid-β (Aβ) plaque deposits in brains. Evidence increasingly showing that epigallocatechin-3-gallate (EGCG) can partly protect cells from Aβ-mediated neurotoxicity inhibiting Aβ aggregation. In order to better understand process aggregation and amyloid fibril disaggregation reduce cytotoxicity EGCG at high doses, we attached onto surface selenium nanoparticles (EGCG@Se). Given low delivery...
Facile and simple method is developed to synthesize silver-nanoparticle-decorated quercetin nanoparticles (QA NPs). Modification suggests that synergistic (Qe) improves the antibacterial effect of silver (Ag Characterization experiment indicates QA NPs have a diameter approximately 10 nm. show highly effective activities against drug-resistant Escherichia coli (E. coli) Staphylococcus aureus (S. aureus). We explore mechanisms using S. E. treated with NPs. Through morphological changes in...
Mitochondrial dysfunction and oxidative damage represent important pathological mechanisms of myocardial ischemia-reperfusion injury (MI/RI). Searching for potential antioxidant agents to attenuate MI/RI is great significance in clinic. Herein, gold–selenium core–shell nanostructures (AS-I/S NCs) with good near-infrared (NIR)-II photoacoustic imaging were designed treatment. The AS-I/S NCs after ischemic myocardium-targeted peptide (IMTP) mitochondrial-targeted SS31 modification achieved...
Photothermal therapy as novel strategy to convert near-infrared (NIR) light into heat for treatment cancers has attracted great attention and been widely studied. However, side effects low efficiency remain the main challenge of precise cancer photothermal therapy. Methods: In this study, we have successfully fabricated characterized dual-targeted gold nanoprisms, whereby bare nanoprisms (Au NPR) were conjugated a phenanthroline derivatives-functionalized tetraphenylethene (TPE) further...
Escherichia coli is an important opportunistic pathogen that could cause inflammation of the udder in dairy cows resulting reduced milk production and changes composition quality, even death cows. Therefore, mastitis main health issue which leads to major economic losses on farms. Antibiotics are routinely used for treatment bovine mastitis. The ability form biofilm increases antibiotic resistance E. coli. Nanoparticles (NPs), a nanosized, safe, highly cost-effective antibacterial agent,...
This study proposes the synthesis of a type anticancer nanoparticle, aptamers and Au nanoparticle (Apt-Au)-modified Morin pH-sensitive liposome (MSL), which exhibits targeting properties. Tumors are difficult to cure because their microenvironment varies from that normal tissue; its pH is lower than tissue, generally impedes effectiveness drugs. Thus, pH-responsive drugs have attracted extensive attention. Gold nanoparticles (AuNPs) show potential as drug carriers small size, good...
Background: Singlet oxygen ( 1 O2) has received considerable research attention in photodynamic therapy (PDT) due to its cytotoxic solid features.However, the inherent hypoxic state of tumor microenvironment (TME) leads meager O2 quantum yield inorganic PDT reagents, and their application vivo remains elusive.Methods: We developed a novel strategy fabricate active photosynthetic bacteria/ photosensitizer/photothermal agent hybrids for oxygenation PTT under different laser irradiation...
Abstract In‐stent restenosis and subsequent thrombosis remain a significant complication following the implantation of coronary stents. Different approaches have been used in developing novel stents to protect against minimize restenosis. In present study, we designed biomacromolecular layer‐by‐layer coating with heparin, vascular endothelial growth factor (VEGF), fibronectin onto nickel‐free titanium surface improve blood compatibility cell proliferation. The multilayer assembling process...
Online teaching has been confirmed as an effective method for maintaining educational quality in many courses. However, it remains unclear whether the effectiveness of face-to-face can be achieved neurosurgery clinical In this study, we aim to analyze effect online on by comparing with traditional and investigating students' willingness engage teaching, well their evaluations mode teaching. We randomly selected three classes fourth year medical students who received After completing...
Abstract Over 90% of gastrointestinal stromal tumors (GISTs) harbor mutations in KIT or PDGFRA that can predict response to tyrosine kinase inhibitor (TKI) therapies, as recommended by NCCN (National Comprehensive Cancer Network) guidelines. However, gene sequencing for mutation testing is expensive and time‐consuming susceptible a variety preanalytical factors. To overcome the challenges associated with genetic screening sequencing, current study we developed an artificial...
ABSTRACT Amyloid‐β (Aβ) deposition was an important pathomechanisms of Alzheimer's disease (AD). Aβ generation highly regulated by beta‐site amyloid precursor protein cleaving enzyme 1 (BACE1), which is a prime drug target for AD therapy. The silence BACE1 function to slow down production accepted as effective strategy combating AD. Herein, interfering RNA, metallothionein (MT) and ruthenium complexes ([Ru(bpy) 2 dppz] 2+ ) were all loaded in Prussian blue nanoparticles (PRM‐siRNA)....