Online teaching has been confirmed as an effective method for maintaining educational quality in many courses. However, it remains unclear whether the effectiveness of face-to-face can be achieved neurosurgery clinical In this study, we aim to analyze effect online on by comparing with traditional and investigating students' willingness engage teaching, well their evaluations mode teaching. We randomly selected three classes fourth year medical students who received After completing...

Objective: To investigate the risk factors affecting facial nerve function following acoustic neuroma surgery via retrosigmoid approach. Methods: Clinical data from 47 patients with treated at Department of Neurosurgery, The First Affiliated Hospital Wannan Medical College, between January 2021 and June 2024, were retrospectively analyzed. All underwent Facial was evaluated using House-Brackmann (H-B) grading system 1 week 6 months postoperatively. Patients divided into 2 groups based on H-B...

This study aimed to determine whether a combination of case-based learning (CBL) and problem-based (PBL) methods in teaching can improve the academic performance recruitment medical students for neurosurgery.Four classes fourth-year were randomly divided into two groups. The traditional model group received method, CBL-PBL combined CBL PBL. After courses, differences between groups self-perceived competence, satisfaction with course, post-class test scores, clinical practice abilities...

Identifying the predictive factors of mortality and functional outcomes following decompressive craniectomy (DC) surgery in patients with malignant middle cerebral artery infarction (MMCAI) is essential for decision-making regarding conservative versus surgical treatment. This study aimed to assess MMCAI after DC identify associated outcomes.

Abstract Enhanced migration is pivotal for the malignant development of glioblastoma (GBM), but underlying molecular mechanism that modulates GBM cells remains obscure. Here we show nuclear factor IX (NFIX) significantly upregulated in human lesions compared with normal or low-grade gliomas. NFIX deficiency impairs and inhibits tumor growth hippocampus immunodeficient nude mice. Mechanistically, silencing suppresses expression Ezrin, a protein crosslinks actin cytoskeleton plasma membrane,...

Abstract Our previous study illustrated that nuclear factor IX (NFIX) promotes glioblastoma (GBM) progression by inducing migration and proliferation of GBM cells. However, the underlying mechanism how NFIX regulates cell remains obscure. In this study, we uncovered Go-Ichi-Ni-San 1 (GINS1) is upregulated positively correlated with in human specimen. silencing downregulates expression GINS1, which pivotal for cell-cycle Replenishment GINS1 largely rescues NFIX-null effect on proliferation....

Traumatic brain injury (TBI) refers to dysfunction with or without traumatic structural induced by an external force. Nevertheless, the molecular mechanism of TBI remains undefined. Differentially expressed (DE) lncRNAs, DEmRNAs and DEmiRNAs were selected between human tissues adjacent histologically normal tissue high-throughput sequencing. Gene ontology enrichment analysis Kyoto Encyclopedia Genes Genomes pathway overlapping predicted mRNAs DEmRNAs. The competitive endogenous RNA (ceRNA)...

Postoperative rebleeding (PRB) is one of the most severe complications after hematoma evacuation spontaneous intracerebral hemorrhage (ICH). PRB has been proven to be an independent risk factor for poor prognosis. Previous studies have shown that spot sign and blend are factors ICH. However, cerebellar (SCH) not elucidated. The aim present study was investigate possible short-term prognosis patients with SCH.This identified 62 SCH who underwent in our department. Risk were by a univariable...

microRNAs (miRNAs), through their regulation of the expression and activity numerous proteins, are involved in almost all cellular processes. As a consequence, dysregulation miRNA is closely associated with development progression cancers. Recently, DNA methylation has been shown to play key role tumors. miRNA-204-5p commonly acts suppression oncogenes In this study, levels were found be down-regulated astrocytoma samples. was also two cell lines (U87MG LN382). Examination online databases...

Objective: Acute epidural hematoma (AEDH) is one of the deadliest lesions in patients after traumatic brain injury. AEDH with swirl sign progresses rapidly and requires timely surgical treatment. This study aims to investigate risk factors for occurrence its prognostic value. Methods: Retrospective analysis was performed on 131 patients, who were divided into group non-swirl based computed tomographic (CT) scan. Patient information, including gender, age, hypertension, mechanism injury,...

Traumatic brain injury (TBI) is a global issue and major cause of patient mortality, cerebral contusions (CCs) common primary TBI. The haemorrhagic progression contusion (HPC) poses significant risk to patients' lives, effectively predicting changes in haematoma volume an urgent clinical challenge that needs be addressed. As branch artificial intelligence, machine learning (ML) can proficiently handle wide range complex data identify connections between for tasks such as prediction decision...

Objective: Few studies concerning aspects of gender-specific differences in chronic subdural hematoma (CSDH). This study aimed to determine whether exist CSDH regarding clinical, radiological characteristics, and prognosis. Methods: A total 585 patients with were retrospectively identified. Patients divided into 2 groups based on gender. Clinical, prognosis compared using Fisher’s exact test or Student t when applicable. The logistic regression model was used identify independent risk...

Abstract Objective: This study aimed to determine whether a combination of case-based learning (CBL) and problem-based (PBL) methods in teaching can improve the academic performance recruitment medical students for neurosurgery. Methods: Four classes fourth-year were randomly divided into two groups. The traditional model group received method, CBL-PBL combined CBL PBL. After courses, differences between groups self-perceived competence, satisfaction with course, postclass test scores,...

<p>S1. Full images of immunoblotting. S2. NFIX knockdown has no effect on p53 and p21 expression. S3. Knockdown GINS1 by shRNAs in U87 cells. S4. represses proliferation GL261 cells S5. rescues the delayed growth NFIX-null tumor. S6. directly up-regulated gene occupying its promoter</p>

<p>S1. Full images of immunoblotting. S2. NFIX knockdown has no effect on p53 and p21 expression. S3. Knockdown GINS1 by shRNAs in U87 cells. S4. represses proliferation GL261 cells S5. rescues the delayed growth NFIX-null tumor. S6. directly up-regulated gene occupying its promoter</p>