A5087830792- Extracellular vesicles in disease
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Nanomaterials in Catalysis
- Nanoplatforms for cancer theranostics
- Intracerebral and Subarachnoid Hemorrhage Research
- S100 Proteins and Annexins
- Heme Oxygenase-1 and Carbon Monoxide
- Venous Thromboembolism Diagnosis and Management
- Ferroptosis and cancer prognosis
- Carbon and Quantum Dots Applications
- Neurosurgical Procedures and Complications
- Nanocluster Synthesis and Applications
- Spinal Hematomas and Complications
- Electrochemical sensors and biosensors
- Blood Coagulation and Thrombosis Mechanisms
- earthquake and tectonic studies
- Sphingolipid Metabolism and Signaling
- Acute Ischemic Stroke Management
- Thermal Regulation in Medicine
- Blood properties and coagulation
- Case Reports on Hematomas
- Intracranial Aneurysms: Treatment and Complications
- Neurological Complications and Syndromes
- High-Temperature Coating Behaviors
- Neuroinflammation and Neurodegeneration Mechanisms
Tianjin Medical University General Hospital
2019-2025
Tianjin Huanhu Hospital
2023-2025
Tianjin Medical University
2020-2023
Ministry of Education of the People's Republic of China
2019-2023
University of Jinan
2022
Neurotrauma is one of the most serious traumatic injuries, which can induce an excess amount reactive oxygen and nitrogen species (RONS) around wound, triggering a series biochemical responses neuroinflammation. Traditional antioxidant-based bandages effectively decrease infection via preventing oxidative stress, but its effectiveness limited to short period time due rapid loss electron-donating ability. Herein, we developed nanozyme-based bandage using single-atom Pt/CeO2 with persistent...
Reactive oxygen and nitrogen species (RONS), especially reactive (RNS) are intermediate products during incidence of nervous system diseases, showing continuous damage for traumatic brain injury (TBI). Here, we developed a carbogenic nanozyme, which shows an antioxidant activity 12 times higher than ascorbic acid (AA) behaves as multienzyme mimetics. Importantly, the nanozyme exhibits ultrahigh scavenging efficiency (∼16 AA) toward highly active RNS, such •NO ONOO– well traditional (ROS)...
Traumatic brain injury (TBI) is a sudden to the brain, accompanied by production of large amounts reactive oxygen and nitrogen species (RONS) acute neuroinflammation responses. Although traditional pharmacotherapy can effectively decrease immune response neuron cells via scavenging free radicals, it always involves in short reaction time as well rigorous clinical trial. Therefore, noninvasive topical treatment method that eliminates radicals still needs further investigation. Methods: In...
Artificial enzymes have attracted wide interest in disease diagnosis and biotechnology due to high stability, easy synthesis, cost effectiveness. Unfortunately, their catalytic rate is limited surface electron transfer, affecting the biological activity. Here, we report an oligomeric nanozyme (O-NZ) with ultrafast achieving ultrahigh O-NZ shows transfer of 1.8 nanoseconds internal cores 1.2 picoseconds between core ligand molecule, leading superoxidase dismutase–like glutathione...
Natural enzymes are efficient and versatile biocatalysts but suffer in their environmental tolerance catalytic stability. As artificial enzymes, nanozymes can improve the stability, it is still a challenge to achieve high activity. Here, we employed atomic engineering build enzyme named Au24Ag1 clusterzyme that hosts an ultrahigh activity as well strong physiological stability via atom manipulation. The designed activates Ag–S active site lattice expansion oligomer layer, showing antioxidant...
Traumatic brain injury often causes poor outcomes and has few established treatments. Neuroinflammation ferroptosis hinder therapeutic progress in this domain. Annexin A5 (A5) anticoagulant, anti-apoptotic anti-inflammatory bioactivities. However, its protective effects on traumatic remain unclear. Thus, we explored whether inhibiting neuroinflammation using could ameliorate injury. We injected recombinant (50 µg/kg) the tail vein of mice 30 min after fluid percussion then assessed modified...
Background Gliomas constitute a category of malignant tumors originating from brain tissue, representing the majority intracranial malignancies. Previous research has demonstrated pivotal role CLEC7A in progression various cancers, yet its specific implications within gliomas remain elusive. The primary objective this study was to investigate prognostic significance and immune therapeutic potential through integration bioinformatics clinical pathological analyses. Methods This investigation...
Traumatic brain injury-induced coagulopathy (TBI-IC) frequently occurs after TBI, exacerbating the severity of TBI and affecting patient prognosis. Benzbromarone (BBR) is commonly used to treat hyperuricemia; however, its protective effects against TBI-IC remain unknown. Therefore, we explored whether BBR could improve TBI. C57BL/6 wild-type mice were subjected fluid percussion injury mimic was administered intraperitoneally 30 min Magnetic resonance imaging (MRI) Evans blue dye...
Background: Patients with cancer often develop a prothrombotic state that can evolve into venous and arterial thrombosis, which is associated poor clinical outcomes. Glioblastoma multiforme (GBM) the most frequently but underlying causes of this are poorly defined. Objectives: We designed study to characterize expression coagulation factor X (FX) its alternatively spliced transcripts in glioblastoma tissues surgically removed from patients clonal cell lines. Methods: The F10 mRNA FX protein...
Objective: To investigate whether methylene blue (MB) treatment can reverse neuronal mitochondrial dysfunction caused by oxygen glucose deprivation/reoxygenation (OGD) injury and then MB reduce apoptosis improve blood-brain barrier (BBB) integrity in traumatic brain (TBI) animals. Methods: Reactive species (ROS), membrane potential (MMP), adenosine triphosphate (ATP) were used to evaluate function. The terminal deoxynucleotidyl transferase-dUTP nick end labeling (TUNEL) assay was assess...
Background and Purpose: Neuroinflammation has been shown to play a critical role in secondary craniocerebral injury, leading poor outcomes for TBI patients. Abrocitinib, Janus kinase1 (JAK1) selective inhibitor approved treat atopic dermatitis (AD) by the Food Drug Administration (FDA), possesses novel anti-inflammatory effect. In this study, we investigated whether abrocitinib could ameliorate neuroinflammation exert neuroprotective effect traumatic brain injury (TBI) models. Methods:...
Previous studies have identified many risk factors related to the recurrence of chronic subdural hematomas (CSDHs). Among these factors, there may be deviations in measuring midline shift, preoperative hematoma volume (PreHV), postoperative residual volume, and pneumocephalus bilateral CSDHs. The aims this study were eliminate impact complicated situations on parameter measurement identify actual predictors for CSDH recurrence, finally, develop a grading system predict unilateral (uCSDH) recurrence.
Traumatic brain injury (TBI) can negatively impact systemic organs, which lead to more death and disability. However, the mechanism underlying effect of TBI on organs remains unclear. In previous work, we found that brain-derived extracellular vesicles (BDEVs) released from injured induce coagulation with a widespread fibrin deposition in microvasculature lungs, kidney, heart mouse model TBI. this study, investigated whether BDEVs heart, lung, liver, kidney mice. The results pathological...
Ultrasmall carbon dot with targeting ability to nitrogen signaling molecules inhibit neuronal death by regulating the activity of endogenous enzymes.
Brain induced extracellular vesicle (BDEV) elevates after traumatic brain injury (TBI) and contributes to secondary injury. However, the role of BDEV in TBI remains unclear. In this study, we determined mechanisms explored whether neuroprotective drug BKca channel opener NS1619 may attenuate BDEV-induced We injected lactadherin, respectively, mimic up downregulation illustrated vivo. vitro, membrane potential calcium concentration HT-22, bEnd3, BV-2 were measured by fluorescent staining. The...
Traumatic brain injury frequently leads to serious mortality and physical disability, yet effective treatments remains insufficient. TBI always a series of secondary injuries including neuronal apoptosis, continuous inflammation, endoplasmic reticulum stress, disruption the blood-brain barrier. Sartans that block angiotensin II type 1 receptors are strongly neuroprotective, neurorestorative anti-inflammatory. However, whether losartan, FDA-approved widely used drug for regulating blood...
The genomic diversity of Avian leukosis virus subgroup J (ALV-J) was investigated in an experimentally infected chicken. ALV-J variants tissues from four different organs the same bird were re-isolated DF-1 cells, and their gp85 gene amplified cloned. Ten clones each organ sequenced compared with original inoculum strain, NX0101. minimum homology ranged 96.7 to 97.6%, lowest between only 94.9%, which much lower than 99.1% NX0101, indicating high ALV-J, even within bird. mutations left...
Aims: Annexin A5 (ANXA5) exhibited potent antithrombotic, antiapoptotic, and anti-inflammatory properties in a previous study. The role of ANXA5 traumatic brain injury (TBI)-induced intestinal is not fully known. Main methods: Recombinant human (50 µg/kg) or vehicle (PBS) was administered to mice via the tail vein 30 min after TBI. Mouse intestine tissue gathered for hematoxylin eosin staining 0.5 d, 1 2 7 d modeling. Intestinal Western blotting, immunofluorescence, TdT-mediated dUTP...