A5017887456- Advanced MEMS and NEMS Technologies
- Mechanical and Optical Resonators
- Advanced Nanomaterials in Catalysis
- Epigenetics and DNA Methylation
- Conducting polymers and applications
- Advanced Sensor and Energy Harvesting Materials
- Neuroscience and Neural Engineering
- Nanoplatforms for cancer theranostics
- Advanced Memory and Neural Computing
- Nanocluster Synthesis and Applications
- Cancer, Hypoxia, and Metabolism
- Advanced Sensor and Control Systems
- Machine Fault Diagnosis Techniques
- Carbon and Quantum Dots Applications
- Force Microscopy Techniques and Applications
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Advanced Surface Polishing Techniques
- Engineering Diagnostics and Reliability
- Organic Electronics and Photovoltaics
- Cancer Mechanisms and Therapy
- Biomimetic flight and propulsion mechanisms
- Analytical Chemistry and Sensors
- Innovative Energy Harvesting Technologies
- Enzyme-mediated dye degradation
Tianjin University
2019-2025
Tianjin Medical University
2021-2025
China Medical University
2020-2024
First Hospital of China Medical University
2020-2024
Southeast University
2024
Shenyang Ligong University
2010-2024
Soochow University
2020-2021
Southwest Jiaotong University
2021
Hebei University of Technology
2018
Shenyang University of Technology
2016-2017
Neurotrauma is one of the most serious traumatic injuries, which can induce an excess amount reactive oxygen and nitrogen species (RONS) around wound, triggering a series biochemical responses neuroinflammation. Traditional antioxidant-based bandages effectively decrease infection via preventing oxidative stress, but its effectiveness limited to short period time due rapid loss electron-donating ability. Herein, we developed nanozyme-based bandage using single-atom Pt/CeO2 with persistent...
Traumatic brain injury (TBI) is a sudden to the brain, accompanied by production of large amounts reactive oxygen and nitrogen species (RONS) acute neuroinflammation responses. Although traditional pharmacotherapy can effectively decrease immune response neuron cells via scavenging free radicals, it always involves in short reaction time as well rigorous clinical trial. Therefore, noninvasive topical treatment method that eliminates radicals still needs further investigation. Methods: In...
Natural enzymes are efficient and versatile biocatalysts but suffer in their environmental tolerance catalytic stability. As artificial enzymes, nanozymes can improve the stability, it is still a challenge to achieve high activity. Here, we employed atomic engineering build enzyme named Au24Ag1 clusterzyme that hosts an ultrahigh activity as well strong physiological stability via atom manipulation. The designed activates Ag–S active site lattice expansion oligomer layer, showing antioxidant...
Using Nafion212 membrane and TEOS solution as raw materials, Nafion212/SiO2 composite membranes were prepared. In the in situ sol-gel reaction process, a series of Nafion/SiO2 prepared by varying temperature time. The effects different modification schemes on studied using SEM, EDS, TEM, TGA, XRD, mechanical tensile experiments, among other methods. results show that at 3°C exhibit well-separated phase structure excellent water retention properties, with uptake 29.23% swelling ratio 24.25%....
Abstract Implanted neural electrodes have been widely used to treat brain diseases that require high sensitivity and biocompatibility at the tissue–electrode interface. However, currently clinical cannot meet both these requirements simultaneously, which hinders effective recording of electronic signals. Herein, nanozyme‐based incorporating bioinspired atomically precise clusters are developed as a general strategy with heterogeneous design for multiscale ultrasensitive via quantum transport...
Protein arginine methyltransferases (PRMTs) regulate protein biological activity by modulating methylation in cancer and are increasingly recognized as potential drug targets. Inhibitors targeting PRMTs currently the early phases of clinical trials more candidate drugs needed. Flavokawain A (FKA), extracted from kava plant, has been a chemotherapy bladder (BC), but its action mechanism remains unclear.We first determined role type II PRMT, PRMT5, BC tissue samples performed cytological...
Mechanical equipment fault detection is critical in industrial applications. Based on vibration signal processing and analysis, the traditional diagnosis method relies rich professional knowledge artificial experience. Achieving accurate feature extraction difficult using such an approach. To learn characteristics of features from data automatically, a deep learning used. A qualitative quantitative for rolling bearing faults based improved convolutional belief network (CDBN) proposed this...
Abstract Background Chemo-resistance of bladder cancer has been considered to be one the serious issues solved. In this study, we revealed pivotal role miR-424 in regulation CDDP sensitivity cells. Methods The cytotoxicity cisplatin and effect were assessed by flow cytometry TUNEL. Transcriptional HIF-1α was Chromatin immunoprecipitation (ChIP). Effect on expression UNC5B , SIRT4 (Sirtuin4) apoptotic markers measured QRT-PCR and/or Western blot. for tested luciferase reporter assay....
A RuN 4 single-atom nanozyme was synthesized and it exhibited multi-enzymatic activities, which effectively alleviated eczema symptoms by ROS clearance.
Wound healing is a complex and dynamic process often accompanied by bacterial infection, inflammation, excessive oxidative stress. Single-atom nanozymes with multi-enzymatic activities show significant potential for promoting the of infected wounds modulating their antibacterial anti-inflammatory properties in response to wound's physiological environment. In this study, we synthesized MN4 single-atom that intelligently respond pH value changes wound process. vitro experiments confirm...
Although the aberrant activation of NOTCH1 pathway causes a malignant progression renal cell carcinoma (RCC), precise molecular mechanisms behind potential action pro-oncogenic NOTCH1/HES1 axis remain elusive. Here, we examined role tumor suppressive miR-138-2 in regulation NOTCH1-HES1-mediated promotion RCC.This study employed bioinformatics, xenotransplant mouse models, ChIP assay, luciferase reporter functional experiments, real-time PCR and Western blot analysis to explore RCC, further...
Abstract Bladder cancer is a common tumor with high recurrence rate and fatality rate, its mechanism of occurrence development remains unclear. Many proteins metabolites reprogram at different stages to support cell growth. The moonlighting effect happens when protein performs multiple functions simultaneously in cell. In this study, we identified metabolic protein, MTHFD2, which participates the cycle by binding CDK2 bladder cancer. MTHFD2 has been shown affect growth, independent function....
Neural electrodes have been widely used to monitor neurological disorders and a major impact on neuroscience, whereas traditional are limited their inherent high impedance, which makes them insensitive weak signals during recording neural signals. Herein, we developed electrode based the graphene/Ag van der Waals heterostructure for improving detection sensitivity signal-to-noise ratio (SNR). The impedance of is reduced 161.4 ± 13.4 MΩ μm2, while cathode charge-storage capacity (CSCc)...
Near-infrared-II (NIR-II, 1000-1700 nm) fluorescence imaging is widely used for in vivo biological imaging. With the unique electronic structures and capability of band-gap engineering, two-dimensional (2D) materials can be potential candidates NIR-II Herein, a theoretical investigation structure optical properties iodine (I)-doped monolayer MoTe2 systems with different doping concentrations carried out through simulations to explore their NIR properties. The results suggest that emergence...
Finding cancer-driver genes has been a central theme of cancer research. We took different perspective; instead considering normal cells, we focused on cancerous cells and that maintained abnormal cell growth, which named cancer-keeper (CKGs). Intervening CKGs may rectify aberrant making them potential therapeutic targets. introduced
This paper introduces a type of out-of-plane microelectrothermal actuator, which is based on the principle bimetal film thermal expansion in fuse. A polymer SU-8 material and nickel are used as functional structural materials actuator. Through heating resistance wire using electricity, actuator produces motion perpendicular axial direction device bias layer contact with substrate, completing signal output. Using Coventorware software to establish three-dimensional model, geometric structure...
Conducting polymer actuators have shown wide application prospects in the field of biomedical sensors and micro-/nanorobotics. In order to explore more applications sensing robotics, it is essential understand actuator static behavior from an engineering perspective, before incorporating them into a design. this article, we established mathematical model trilayer polypyrrole (PPy) cantilever validated experimentally. The helps enhancing efficiency improving performance, predictability,...
Effective depolymerization of lignin is the most important step for its comprehensive utilization. So far, studies on focused batch processing, whereas only a few relied microreactor. In this study, we developed continuous-flow microreactor into monomeric and oligomeric compounds. The yields monomers oligomers can be adjusted by varying temperature, pressure, residence time, NaOH dosage, solvent. Under optimized conditions, conversion rate was 77.73 wt %, monomer yield 13.26 with 77.81%...
Excessive accumulation of reduced nicotinamide adenine dinucleotide (NADH) within biological organisms is closely associated with many diseases. It remains a challenge to efficiently convert superfluous and detrimental NADH NAD+. oxidase (NOX) crucial oxidoreductase that catalyzes the oxidation Herein, M1M2 (Mi=V/Mn/Fe/Co/Cu/Mo/Rh/Ru/Pd, i = 1 or 2) mated-atom nanozymes (MANs) are designed by mimicking natural enzymes polymetallic active centers. Excitingly, RhCo MAN possesses excellent...