A5101601481- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Advanced Nanomaterials in Catalysis
- Nanocluster Synthesis and Applications
- Nanoplatforms for cancer theranostics
- Carbon and Quantum Dots Applications
- Advanced biosensing and bioanalysis techniques
- Membrane Separation Technologies
- Neuroscience and Neural Engineering
- Electrochemical sensors and biosensors
- Gold and Silver Nanoparticles Synthesis and Applications
- Advancements in Solid Oxide Fuel Cells
- Nanomaterials for catalytic reactions
- Crystallography and molecular interactions
- Magnesium Oxide Properties and Applications
- Orbital Angular Momentum in Optics
- Analytical Chemistry and Sensors
- Graphene and Nanomaterials Applications
- Catalysts for Methane Reforming
- Advanced Fluorescence Microscopy Techniques
- Inflammation biomarkers and pathways
- Microplastics and Plastic Pollution
- Nanoparticles: synthesis and applications
- Nanopore and Nanochannel Transport Studies
- Advanced Photocatalysis Techniques
Tianjin Medical University
2022-2024
Tianjin University
2023-2024
Ningbo University
2023-2024
Xiangya Hospital Central South University
2024
Central South University
2024
Tianjin Medical University General Hospital
2022
Sun Yat-sen University
2022
Nanjing Tech University
2021
East China University of Science and Technology
2016-2017
State Key Laboratory of Chemical Engineering
2016
Strong fluorescence and high catalytic activities cannot be achieved simultaneously due to conflicts in free electron utilization, resulting a lack of bioactivity most near-infrared-II (NIR-II) fluorophores. To circumvent this challenge, we developed atomically precise Au22 clusters with strong NIR-II ranging from 950 1300 nm exhibiting potent enzyme-mimetic through atomic engineering create active Cu single-atom sites. The Au21Cu1 show 18-fold higher antioxidant, 90-fold catalase-like,...
Abstract Implanted neural electrodes have been widely used to treat brain diseases that require high sensitivity and biocompatibility at the tissue–electrode interface. However, currently clinical cannot meet both these requirements simultaneously, which hinders effective recording of electronic signals. Herein, nanozyme‐based incorporating bioinspired atomically precise clusters are developed as a general strategy with heterogeneous design for multiscale ultrasensitive via quantum transport...
Near-infrared-II (NIR-II) imaging has shown great potential in medical diagnosis and surgical navigation, but developing safe, photostable, high-brightness molecular probes remains a challenge. Due to their ultrasmall size resulting highly efficient renal clearance, gold nanoclusters have clinical potential. In this work, we systematically explored the effect of different ligands on luminescence bioactivity nanoclusters. Our results show that protected by thioglycolic acid (TGA)...
Introduction Few advances have been made in treating T-cell acute lymphoblastic leukemia (T-ALL). Approaches targeting histone deacetylases (HDAC) not thoroughly investigated T-ALL. However, the underlying molecular mechanism of HDAC inhibition remains to be fully elucidated.<br />Objectives The study aimed evaluate clinical outcome chidamide (an oral selective inhibitor for HDAC1, HDAC2, HDAC3, and HDAC10) combination with chemotherapy relapsed or refractory T-ALL explore T-ALL.<br...
CO oxidation is a typical heterogeneous catalytic reaction. Development of active and stable low-temperature catalysts has been one the hot topics in field catalysis. In this work, we explored application series Au supported on CeO2 foam using modified deposition-precipitation method for oxidation. Among them, catalyst with 1.1% loading content showed highest activity, leading to total conversion at 20 °C. Based strategy stepwise reduction content, finally obtained atomically monodisperse...
Ultrasmall Au
Sepsis, a life-threatening condition caused by dysregulated immune response to infection, leads systemic inflammation, dysfunction, and multiorgan damage. Various oxidoreductases play very important role in balancing oxidative stress modulating the response, but they are stored inconveniently, environmentally unstable, expensive. Herein, we develop multifunctional artificial enzymes, CeO2 Au/CeO2 nanozymes, exhibiting five distinct enzyme-like activities, namely, superoxide dismutase,...
Nanomedicine shows remarkable potential to improve the efficacy of diagnosis and treatment tumors, utilizing nanotechnologies nanomaterials. Gold nanoclusters (AuNCs) have emerged as a highly promising option due their exceptional optical enzyme‐mimicking catalytic activities well good biocompatibility. The renal clearable clusters can enrich in tumors upon enhanced permeability retention properties, which benefits tumor‐related applications. fluorescence AuNCs second near‐infrared region...
Breast cancer (BC) is the most common tumor worldwide and requires crucial molecular typing for treatment prognosis assessment. Currently, approaches like pathological staining, immunohistochemistry (IHC), immunofluorescence (IF) face limitations due to low signal-to-background ratio (SBR) high heterogeneity, resulting in a misdiagnosis rate. Fluorescent assay second near-infrared region (NIR-II, 1000–1700 nm) exhibits ultrahigh SBR owing diminished scattering tissue autofluorescence. Here,...
A three-dimensional computational fluid dynamics (CFD) method coupled with multi-physics phenomena is developed and applied for a 10-cell full-scale SOEC stack in this study. Effects of gas flow patterns, operating temperature, manifold configurations are simulated analyzed performance thermal stress. It demonstrated the hydrogen production stress obtained cross-flow mode about 8% 36 MPa higher compared to that other cases. Furthermore, it found temperature gradient predominant factor...
The orientation of exposed crystal facets is great significance for the materials to play a role in processes adsorption and catalysis. However, it awkward adjust identify proportions various quantitatively, especially with regard hierarchical materials. In this study, synthesis two types γ-AlOOH both self-assembled by secondary nanosheets but different dimensions was achieved facilely hydrothermal method. three primary on were adjusted changing solvent anion type, their values calculated...
Endotoxemia remains a major cause of mortality in the intensive care unit, but therapeutic strategy is still lacking. Mesenchymal stem cell (MSC) was reported with tissue-oriented differentiation ability and an excellent immunoregulatory capacity. However, immunity signaling pathways that govern MSC modulation effect are not completely understood. In our current study, MSCs (2.5 × 10 5 /ml) were obtained stimulated IFN-γ (20 ng/ml) for 72 h. Gal-9 expression on measured by ELISA, RT-PCR,...
Excessive accumulation of reduced nicotinamide adenine dinucleotide (NADH) within biological organisms is closely associated with many diseases. It remains a challenge to efficiently convert superfluous and detrimental NADH NAD+. oxidase (NOX) crucial oxidoreductase that catalyzes the oxidation Herein, M1M2 (Mi=V/Mn/Fe/Co/Cu/Mo/Rh/Ru/Pd, i = 1 or 2) mated-atom nanozymes (MANs) are designed by mimicking natural enzymes polymetallic active centers. Excitingly, RhCo MAN possesses excellent...
Neural electrodes are the core components of neural interfaces, which widely used in diagnosis and treatment neurological disorders by accurately detecting regulating bioelectric activity. However, traditional face challenges such as low acquisition sensitivity poor biocompatibility due to limited charge injection capability mechanical mismatch at tissue–electrode interface. Herein, we developed two-dimensional (2D) quantum material-modified based on WSe2 WS2 dots (QDs) that achieved...
Clay-based 2D nanofiltrations (NFs) have shown great potentials in wastewater treatment owing to their facile scale-up and low-cost feature. However, the swelling effect seriously limits separation efficient towards construction of high-performance NFs. Herein, an anti-swelling clay-based NF is developed based on strategy electrostatic interlamellar fixation. The intercalation positively-charged Fe(OH)3 nanoparticles could effectively fix interlayer spacing negatively-charged...
Silk sutures are common in surgeries, and silk-based textiles widely used clinical medicine on account of their great mechanical properties biodegradability. However, due to the lack biocatalytic activity, silk show unsatisfactory anti-inflammatory healing speed. To address this constraint, we construct grade bioactive gold cluster-sutures through a heterojunction. The antioxidant activity is ∼160 times more than that sutures. Meanwhile, suture displays superb reactive oxygen species (ROS)...
Mechanical failures in the operating stacks of solid oxide fuel cells (SOFCs) are frequently related to thermal stresses generated by a temperature gradient and its variation. In this study, computational fluid dynamics (CFD) model is developed further applied full-size SOFC stacks, which fully coupled implemented for analysis heat flow electrochemical phenomena, aiming predict stress distribution. The primary object present investigation explore features characteristics influenced reactions...
Clay-based 2D nanofiltrations (NFs) have shown great potentials in wastewater treatment owing to their facile scale-up and low-cost feature. However, the swelling effect seriously limits separation efficient towards construction of high-performance NFs. Herein, an anti-swelling clay-based NF is developed based on strategy electrostatic interlamellar fixation. The intercalation positively-charged Fe(OH)3 nanoparticles could effectively fix interlayer spacing negatively-charged...