A5055292378- Traumatic Brain Injury and Neurovascular Disturbances
- Heme Oxygenase-1 and Carbon Monoxide
- Extracellular vesicles in disease
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroinflammation and Neurodegeneration Mechanisms
- S100 Proteins and Annexins
- Neuroscience and Neuropharmacology Research
- Immune Response and Inflammation
- Thermal Regulation in Medicine
- Blood Coagulation and Thrombosis Mechanisms
Tianjin Medical University General Hospital
2022-2025
Capital Medical University
2025
Ministry of Education of the People's Republic of China
2024
Traumatic brain injury (TBI) can induce systemic coagulopathy and inflammation, thereby increasing the risk of mortality disability. However, mechanism causing inflammation following TBI remains unclear. In prior research, we discovered that brain-derived extracellular vesicles (BDEVs), originating from injured brain, activate coagulation cascade inflammatory cells. this study, primarily investigated how BDEVs affect in peripheral circulation. The results cytokines function indicated lead to...
Traumatic brain injury-induced coagulopathy (TBI-IC) frequently occurs after TBI, exacerbating the severity of TBI and affecting patient prognosis. Benzbromarone (BBR) is commonly used to treat hyperuricemia; however, its protective effects against TBI-IC remain unknown. Therefore, we explored whether BBR could improve TBI. C57BL/6 wild-type mice were subjected fluid percussion injury mimic was administered intraperitoneally 30 min Magnetic resonance imaging (MRI) Evans blue dye...
Brain induced extracellular vesicle (BDEV) elevates after traumatic brain injury (TBI) and contributes to secondary injury. However, the role of BDEV in TBI remains unclear. In this study, we determined mechanisms explored whether neuroprotective drug BKca channel opener NS1619 may attenuate BDEV-induced We injected lactadherin, respectively, mimic up downregulation illustrated vivo. vitro, membrane potential calcium concentration HT-22, bEnd3, BV-2 were measured by fluorescent staining. The...