A5048471649- Nanoplatforms for cancer theranostics
- Selenium in Biological Systems
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Advanced biosensing and bioanalysis techniques
- Metal complexes synthesis and properties
- Carbon and Quantum Dots Applications
- Advanced Nanomaterials in Catalysis
- Inflammasome and immune disorders
- Chemotherapy-induced organ toxicity mitigation
- Phytochemistry and Bioactive Compounds
- Graphene and Nanomaterials Applications
- Nanoparticle-Based Drug Delivery
- DNA and Nucleic Acid Chemistry
- Intracranial Aneurysms: Treatment and Complications
- Ferroptosis and cancer prognosis
- Coenzyme Q10 studies and effects
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Anesthesia and Neurotoxicity Research
- Folate and B Vitamins Research
- Cell death mechanisms and regulation
- Intracerebral and Subarachnoid Hemorrhage Research
- Trace Elements in Health
- Cancer, Hypoxia, and Metabolism
Shandong First Medical University
2019-2025
Affiliated Hospital of Taishan Medical University
2022-2025
China Jiliang University
2024
Anhui Agricultural University
2023
Academy of Medical Sciences
2022
Taian City Central Hospital
2020
Taishan Medical University
2014-2019
Jinan University
2011-2014
Surface charge plays a key role in cellular uptake and biological actions of nanomaterials. Selenium nanoparticles (SeNPs) are novel Se species with potent anticancer activity low toxicity. This study constructed positively charged SeNPs by chitosan surface decoration to achieve selective enhanced efficacy. The results structure characterization revealed that hydroxyl groups reacted SeO32– ion form special chain-shaped intermediates, which could be decomposed crystals upon reduction ascorbic...
Abstract Irreversible bacterial resistance and impenetrable biofilms have rendered conventional antibiotic therapy ineffective. Nevertheless, increasing evidence has confirmed that carbon nanodots (CDs) exhibit potent antibacterial activity. However, the complex chemical composition of CDs, and, hence, their mechanism, is difficult to understand. The design new CDs against an urgent requirement.In this study, kanamycin‐sulfate‐derived (KCDs) are found significant potential with assistance...
Abstract Cardiovascular disease is the leading cause of death worldwide. Reperfusion therapy vital to patient survival after a heart attack but can myocardial ischemia/reperfusion injury (MI/RI). Nitric oxide (NO) ameliorate MI/RI and key molecule for drug development. However, reactive oxygen species (ROS) easily oxidize NO peroxynitrite, which causes secondary cardiomyocyte damage. Herein, L‐arginine‐loaded selenium‐coated gold nanocages (AAS) are designed, synthesized, modified with PCM...
MCC950, an NLRP3 inflammasome inhibitor, displays multiple pharmacological properties. However, the protective potential and underlying mechanism of MCC950 against doxorubicin (DOX)-induced myocardial injury has not been well investigated yet. Herein, DOX-induced in mice H9c2 cells was investigated, effects were fully explored. The results showed that co-treatment significantly improved function, inhibited inflammatory fibrosis, attenuated cardiomyocyte pyroptosis DOX-treated mice....
Mitochondrial dysfunction and oxidative damage represent important pathological mechanisms of myocardial ischemia-reperfusion injury (MI/RI). Searching for potential antioxidant agents to attenuate MI/RI is great significance in clinic. Herein, gold–selenium core–shell nanostructures (AS-I/S NCs) with good near-infrared (NIR)-II photoacoustic imaging were designed treatment. The AS-I/S NCs after ischemic myocardium-targeted peptide (IMTP) mitochondrial-targeted SS31 modification achieved...
A series of ruthenium complexes containing bis-benzimidazole derivatives have been synthesized and identified as able to target mitochondria induce caspase-dependent apoptosis in cancer cells through superoxide overproduction.
// Cundong Fan 1 , Wenjie Zheng Xiaoyan Fu Xiaoling Li Yum-Shing Wong 2 Tianfeng Chen Department of Chemistry, Jinan University, Guangzhou 510632, China School Life Sciences and State Key Laboratory Agrobiotechnology, The Chinese University Hong Kong, Kong S.A.R., Correspondence: Chen, email: Keywords : selenocystine; synergism; doxorubicin; apoptosis; reactive oxygen species Received January 1, 2014 Accepted March 24, Published 25, Abstract Doxorubicin-based chemotherapy represents one the...
In the present study, two zinc(II) complexes containing bis-benzimidazole derivatives, Zn(bpbp)Cl2 (1) and [Zn(bpbp)2](ClO4)2·CH3CH2OH·H2O (2) (bpbp = 2,6-bis(1-phenyl-1H-benzo[d]imidazol-2-yl)pyridine), have been designed, synthesized evaluated for their in vitro anticancer activities. The underlying molecular mechanisms through which they caused cancer cell death were also elucidated. identified as potent antiproliferative agents against a panel of five human lines by comparing with...
The most frequent adverse effect of cisplatin-based chemotherapy is nephrotoxicity. Oxidative stress has been implicated as an important mechanism in the pathogenesis cisplatin-induced In present study, 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (trolox) surface-functionalized selenium nanoparticles (Se@Trolox) with enhanced antioxidant activity have prepared by self-assembly trolox on surface nanoparticles, and their nephroprotective effects investigated. Functionalization...
Fucoxanthin, a natural carotenoid derived from algae, exhibits novel anticancer potential. However, fucoxanthin with high purity is hard to prepare, and the mechanism remains elusive. In present study, was prepared purified marine microalgae Nitzschia sp. by silica-gel column chromatography (SGCC), underlying against human glioma cells evaluated. The results showed that time- dose-dependently inhibited U251-human-glioma-cell growth induction of apoptosis (64.4 ± 4.8, P < 0.01) accompanied...
Photothermal therapy as novel strategy to convert near-infrared (NIR) light into heat for treatment cancers has attracted great attention and been widely studied. However, side effects low efficiency remain the main challenge of precise cancer photothermal therapy. Methods: In this study, we have successfully fabricated characterized dual-targeted gold nanoprisms, whereby bare nanoprisms (Au NPR) were conjugated a phenanthroline derivatives-functionalized tetraphenylethene (TPE) further...
Homocysteine (Hcy) as an independent risk factor contributes to the occurrence and development of human cardiovascular diseases (CVD). Induction oxidative stress apoptosis was commonly accepted major mechanism in Hcy-induced cardiotoxicity. Astaxanthin (ATX) one most powerful antioxidants exhibits novel cardioprotective potential against endothelial dysfunction. However, protective effect ATX cardiotoxicity cardiomyocytes have not been elucidated yet. Herein, H9c2 rat Hcy-injured animal...
Calycosin (CAL) is the main active component present in Astragalus and reportedly possesses diverse pharmacological properties. However, cardioprotective effect underlying mechanism of CAL against doxorubicin- (DOX-) induced cardiotoxicity need to be comprehensively examined. Herein, we aimed investigate whether effects are related its antipyroptotic effect. A cardiatoxicity model was established by stimulating H9c2 cells C57BL/6J mice using DOX. In vitro, increased cell viability decreased...
Background: Singlet oxygen ( 1 O2) has received considerable research attention in photodynamic therapy (PDT) due to its cytotoxic solid features.However, the inherent hypoxic state of tumor microenvironment (TME) leads meager O2 quantum yield inorganic PDT reagents, and their application vivo remains elusive.Methods: We developed a novel strategy fabricate active photosynthetic bacteria/ photosensitizer/photothermal agent hybrids for oxygenation PTT under different laser irradiation...
Regulated cell death is a genetically determined form of programmed that commonly occurs during the development living organisms. This process plays crucial role in modulating homeostasis and evolutionarily conserved across diverse range Ferroptosis classic regulatory mode death. Extensive studies Alzheimer's disease have yielded increasing evidence ferroptosis closely related to occurrence, development, prognosis disease. review summarizes molecular mechanisms recent research advances Our...
DNA has been identified as a primary target for anticancer drug design and remains one of the most promising biological receptors development chemotherapeutic agents. We have previously demonstrated that ruthenium complex [Ru(bmbp)(phen)Cl]ClO(4) (RuBmP; bmbp = 2,6-bis(4-methylbenzimidazol-2-yl)pyridine) is novel apoptosis-inducer by triggering mitochondria-mediated ROS overproduction in cancer cells. In present work, underlying mechanisms action RuBmP were further elucidated evaluating its...