A5050838680- Alzheimer's disease research and treatments
- Luminescence and Fluorescent Materials
- Nanoplatforms for cancer theranostics
- Neuroinflammation and Neurodegeneration Mechanisms
- Medicinal Plants and Bioactive Compounds
- Pharmacological Effects of Natural Compounds
- Neurological Disease Mechanisms and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced Radiotherapy Techniques
- Immune Response and Inflammation
- Aquaculture disease management and microbiota
- Tryptophan and brain disorders
- Helicobacter pylori-related gastroenterology studies
- Andrographolide Research and Applications
- Bioinformatics and Genomic Networks
- Radical Photochemical Reactions
- Advanced Photocatalysis Techniques
- Gastroesophageal reflux and treatments
- Photodynamic Therapy Research Studies
- Saffron Plant Research Studies
- Thermal Regulation in Medicine
- Traditional Chinese Medicine Analysis
- RNA and protein synthesis mechanisms
- Gastric Cancer Management and Outcomes
- Fullerene Chemistry and Applications
Inner Mongolia University
2022-2025
Shandong First Medical University
2023-2024
National University of Mongolia
2024
Affiliated Hospital of Taishan Medical University
2023-2024
Huazhong University of Science and Technology
2022-2024
Hubei Cancer Hospital
2023-2024
Changchun University of Chinese Medicine
2021-2024
Heilongjiang University of Chinese Medicine
2024
Tongji Hospital
2022-2023
Hohai University
2023
Tumor hypoxia seriously impairs the therapeutic outcomes of type II photodynamic therapy (PDT), which is highly dependent upon tissue oxygen concentration. Herein, a facile strategy acceptor planarization and donor rotation proposed to design I photosensitizers (PSs) photothermal reagents. Acceptor can not only enforce intramolecular charge transfer redshift NIR absorption but also PSs from photochemical pathways. Donor optimizes conversion efficiency (PCE). Accordingly, three...
The performances of second near-infrared (NIR-II) organic phototheranostic agents (OPTAs) depend on both molecular structure and packing when used as nanoparticles (NPs). Herein, we proposed a facile structural isomerization-induced 3D spatial donor (D)-acceptor (A) interlocked network for achieving NIR-II OPTAs. Two isomers, 4MNVDPP 6MNVDPP were synthesized formulated into NPs. 6MNVDPP, which has larger electrostatic potential difference, exhibits compact D-A in the crystal form, while...
The low oxygen dependence of type I photosensitizers (PSs) has made them a popular choice for treating solid tumors. However, the drawbacks poor water solubility, short emission wavelength, stability, and inability to distinguish cancer cells from normal limit application most PSs in clinical therapy. Thereby, developing novel overcoming these problems is an urgent but challenging task. Herein, by utilizing distinctive structural characteristics anion-π+ interactions, highly water-soluble PS...
Type I photosensitizers (PSs) with an aggregation-induced emission (AIE) feature have received sustained attention for their excellent theranostic performance in the treatment of clinical diseases. However, development AIE-active type PSs strong reactive oxygen species (ROS) production capacity remains a challenge due to lack in-depth theoretical studies on aggregate behavior and rational design strategies. Herein, we proposed facile oxidization strategy enhance ROS generation efficiency...
Oxidative stress was thought to be associated with acrylamide cytotoxicity, but the link between oxidative and cytotoxicity in gastrointestinal tract, primary organ contact dietary acrylamide, is still unclear. This study conducted evaluate antioxidant activity of natural compound myricitrin its protective role against cytotoxicity. We found that can effectively scavenge multiple free radicals (including DPPH radical, hydroxyl ABTS radical) a concentration-dependent manner. Our results...
Liver cancer is the third leading cause of death worldwide and about half patients with liver require adjuvant therapy after surgical resection. Therefore, development novel agents to eradicate cells may constitute a viable approach treat cancer. Andrographolide, diterpenoid lactone isolated from Andrographis paniculata , known possess potent antioxidant, anti-inflammatory, antineoplastic antiviral properties. In this study, we investigated cytotoxic effect andrographolide on human explored...
Regulated cell death is a genetically determined form of programmed that commonly occurs during the development living organisms. This process plays crucial role in modulating homeostasis and evolutionarily conserved across diverse range Ferroptosis classic regulatory mode death. Extensive studies Alzheimer's disease have yielded increasing evidence ferroptosis closely related to occurrence, development, prognosis disease. review summarizes molecular mechanisms recent research advances Our...
In spite of impressive success in treating hematologic malignancies, adoptive therapy with chimeric antigen receptor modified T cells (CAR T) has not yet been effective solid tumors, where identification suitable tumor-specific antigens remains a major obstacle for CAR T-cell due to the “on target off tumor” toxicity. Protein tyrosine kinase 7 (PTK7) is member Wnt-related pseudokinases and identified as highly expressed enriched cancer stem (CSCs) from multiple including but limited...
Alzheimer's disease (AD) is a fatal neurodegenerative with subtle and progressive onset the most common type of dementia. However, its etiology pathogenesis have not yet been fully elucidated. The pathological manifestations AD include extraneuronal β-amyloid deposition (Aβ), intraneuronal tau protein phosphorylation leading to formation 'neurofibrillary tangles' (NFTs), neuroinflammation, loss brain neurons/synapses, glucose metabolism disorders. Current treatment approaches for primarily...
Conjugated polymers are becoming popular near-infrared II (NIR-II) phototheranostic agents (PTAs) due to their numerous advantages, such as high photostability, large molar extinction coefficients, and excellent photothermal properties. However, the strong π-π interactions between chains of conjugated resulted in generally low NIR-II emission quantum yields (QY). Therefore, synthesis with QY is an interesting but challenging task. Herein, we proposed a spacer twisting strategy realize...
Objective Prenatal depression is a prevalent mental health challenge encountered during pregnancy and notably associated with adverse maternal neonatal outcomes. This study aimed to elucidate the likelihood determinants of depressive symptoms among pregnant individuals in Beijing, thereby laying foundational framework for theoretical underpinning prenatal screening preemptive interventions disorders. Methods The dataset was derived from 4,564 Beijing utilizing cross-sectional survey...
Abstract Introducing two pyrrole rings at the armchair edges of perylene creates small, electron‐rich molecular bowl 1 , which can be viewed as a nitrogen‐doped end‐cap C 70 . Despite numerous attempts since 2008, its synthesis has been hindered by strain and synthetic challenges. In this study, we present property analysis dimer, wavy‐shaped nanographene 2 Substituents on nitrogen atoms significantly affect depth, intermolecular interactions, supramolecular behaviors. Consequently,...
Abstract Introducing two pyrrole rings at the armchair edges of perylene creates small, electron‐rich molecular bowl 1 , which can be viewed as a nitrogen‐doped end‐cap C 70 . Despite numerous attempts since 2008, its synthesis has been hindered by strain and synthetic challenges. In this study, we present property analysis dimer, wavy‐shaped nanographene 2 Substituents on nitrogen atoms significantly affect depth, intermolecular interactions, supramolecular behaviors. Consequently,...
Near-infrared II (NIR-II) phototheranostic agents have become prominent for the early diagnosis and precise treatment of cancer. Organic open-shell diradicaloids with distinct structure narrow band gap are promising candidates phototherapeutic due to their strong spin-coupling effect NIR light-harvesting capacity. However, achieving stable efficient NIR-II luminescent is crucial yet rather challenging considering high chemical reactivity self-absorption. Herein, two highly diradicaloids,...