A5100401701- Pectus Deformity Diagnosis and Treatment
- Inflammasome and immune disorders
- Pancreatitis Pathology and Treatment
- Pelvic and Acetabular Injuries
- Pancreatic and Hepatic Oncology Research
- Cardiac Ischemia and Reperfusion
- Gout, Hyperuricemia, Uric Acid
- Genital Health and Disease
- Gallbladder and Bile Duct Disorders
- Autoimmune and Inflammatory Disorders Research
- Vascular anomalies and interventions
- Knee injuries and reconstruction techniques
- Systemic Lupus Erythematosus Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Antioxidant Activity and Oxidative Stress
- T-cell and B-cell Immunology
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- COVID-19 Clinical Research Studies
- Cholesterol and Lipid Metabolism
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Traditional Chinese Medicine Analysis
- Automotive and Human Injury Biomechanics
- Nitric Oxide and Endothelin Effects
- Pulmonary Hypertension Research and Treatments
- Hippo pathway signaling and YAP/TAZ
Jining First People's Hospital
2025
Guiyang Medical University
2023
Hebei Medical University
2022
Shandong University of Traditional Chinese Medicine
2020-2022
Third Hospital of Hebei Medical University
2022
Capital Medical University
2018-2021
National Clinical Research Center for Digestive Diseases
2020-2021
Beijing Friendship Hospital
2020-2021
Shandong Provincial QianFoShan Hospital
2019-2021
Beijing Children’s Hospital
2018-2019
MCC950, an NLRP3 inflammasome inhibitor, displays multiple pharmacological properties. However, the protective potential and underlying mechanism of MCC950 against doxorubicin (DOX)-induced myocardial injury has not been well investigated yet. Herein, DOX-induced in mice H9c2 cells was investigated, effects were fully explored. The results showed that co-treatment significantly improved function, inhibited inflammatory fibrosis, attenuated cardiomyocyte pyroptosis DOX-treated mice....
Calycosin (CAL) is the main active component present in Astragalus and reportedly possesses diverse pharmacological properties. However, cardioprotective effect underlying mechanism of CAL against doxorubicin- (DOX-) induced cardiotoxicity need to be comprehensively examined. Herein, we aimed investigate whether effects are related its antipyroptotic effect. A cardiatoxicity model was established by stimulating H9c2 cells C57BL/6J mice using DOX. In vitro, increased cell viability decreased...
Abstract Increasing evidences demonstrate that chlorogenic acid (CGA), a polyphenol with multiple effects such as anti-inflammatory and anti-oxidation, protects against myocardial ischemia–reperfusion injury (MIRI) in vitro vivo. But its detailed cardiac protection mechanism is still unclear. The MIRI mice model was established by ligating the left anterior descending branch (LAD) of coronary artery C57BL/6 mice. Sixty were randomly divided into four groups. CGA group + I/R (each n = 15)...
The ancient traditional Chinese medicine Qishenkeli (QSKL) is widely used in the treatment of heart failure (HF) China. Previous studies have shown that QSKL has definite effects on HF. purpose this study to identify regulation apoptosis and clarify underlying mechanism. An model H9C2 cells was induced by oxygen-glucose deprivation/recovery (OGD/R). animal HF ligation left anterior descending (LAD) coronary artery rat. We found reduced intracellular ROS generation, increased mitochondrial...
Abstract Background Anterior cruciate ligament (ACL) injury could lead to functional impairment along with disabilities. ACL reconstruction often fails owing the regeneration failure of tendon–bone interface. Herein, we aimed investigate effects Runt related transcription factor 1 (RUNX1) on healing after using bone mesenchymal stem cells (BMSCs). Methods BMSCs were isolated from marrow cavity rat femur, followed by modification RUNX1 lentiviral system. Then, an model rats was established...
Abstract Background Studies have shown that inflammation promoted atherosclerotic progression; however, it remains unclear whether progression properties by altering cholesterol metabolism in human macrophages. In the present study, we evaluated a potential mechanism of on atherogenic effects. We ability TNFa to affect Reverse transport (RCT) and uptake its mechanism(s) action Results initially determined effects efflux also alterations mRNA protein levels ABCA1, ABCG1, LXRa, CD-36, SR-A...
Acute pancreatitis (AP), an inflammatory disorder of the pancreas, can cause systemic responses. Escin Sodium (ES), a natural mixture triterpene saponins extracted from dry ripe fruit Fructus Aesculi or horse chestnut crude, has been demonstrated to have antiedematous, anti-inflammatory, and antiexudative effects. We here aim investigate effects ES pretreatment on AP in vivo vitro explore its potential molecular mechanism. In present study, we that could apparently decrease amylase lipase,...
Endoscopic ultrasound (EUS)-guided transmural drainage for pancreatic fluid collections (PFCs) has become the first-line treatment with quicker recovery and more minor injury compared surgery percutaneous drainage. The efficacy of stents implantation different PFCs remains controversial, especially lumen-apposing metal (LAMS). This study aimed to compare safety LAMS pseudocysts (PPC) walled-off necrosis (WON).A meta-analysis was performed WON PPC by systematically searching PubMed, Cochrane,...
Objective By measuring the thoracic cage index with chest X-ray film in 3-17 years old healthy children, analyzing bivariate correlations age, to provide reference data for evaluating and following up of wall deformity. Methods A retrospective study was conducted 450 cases health physical examination from May 2013 March 2016 our institution. The anterior intercostal space width(IS), rib width(RW), thickness middle(RT) on right side 3-7 ribs have been measured each patient. Statistical...
Objective To explore the application of finite element method in biomechanical analysis rib cage and simulation mini-invasive surgery for correcting pectus carinatum. Methods Based on a model bar established by methods, was assembled ABAQUS software.The position parallel to xx axis highest sternum set as base (set point) another 3 + 20 mm, 10 mm -10 zz direction respectively.After setting similar size concentrated force yy axis, software utilized calculating stress distribution...
Objective To explore the establishment of 3D thoracic model by finite element methods, and study mechanical mechanism minimally invasive surgery for correcting chest wall deformity, provide personalized solution in future. Methods According to admission exclusion criteria, we selected 10 cases pectus carinatum that received CT scan. The was established analyzed Mimics, ABAQUS, etc. validity method verified comparing sternal displacement between simulated values actual with same...
Objective To evaluate the thoracic status of patients with funnel chest by quantitative evaluation X-ray, and to explore effect Nuss surgery. Methods From October 2006 February 2011, according inclusion criteria, there were 47 cases enrolled our group at last, then divided into 3 groups, including pre-operative procedure, recent post-bar removal further removal. We measured data on radiography statistical analysis, maximal distance outer boundary each rib pairs(C, from 1st pair 9th),...
Objective To evaluate the efficacy of using sternal suspension technique in correcting pectus excavatum after open repair congenital heart disease and improve safety this technique. Methods A retrospective study was conducted for 8 cases treated with procedure from October 2005 to 2018 our institution, 5 males 3 females. The median age patients 5.75 years (range 3.75-12.33 years) Haller index 4.20(range 3.60-5.19). All underwent cardiac ultrasound chest CT scan severity retrosternal...
Objective To provide data references for Nuss procedure biomechanics research, and to understand morphological pathological changes in children with pectus excavatum. Methods A retrospective study was conducted 434 cases of excavatum from January 2009 December 2015 our institution. The anterior rib width(RW), intercostal space width(IS) thickness the middle(RT) on right side 3-7 ribs had been measured each patient. widths were compared between IS bar which currently used clinic....
Abstract Background and Aims: Endoscopic ultrasound-guided transmural drainage for pancreatic fluid collections (PFCs) has become the first-line treatment with quicker recovery less injury compared surgery percutaneous drainage. The efficacy of stents implantation different types PFCs remains controversial, especially lumen-apposing mental (LAMS). This study aims to compare safety LAMS pseudocysts (PPC) walled-off necrosis (WON). Methods: A meta-analysis was performed WON PPC by...