A5036055245- Estrogen and related hormone effects
- Retinoids in leukemia and cellular processes
- Antioxidant Activity and Oxidative Stress
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Cancer-related gene regulation
- Hormonal Regulation and Hypertension
- Hepatitis C virus research
- Connective tissue disorders research
- Ubiquitin and proteasome pathways
- Acute Lymphoblastic Leukemia research
- Immune Response and Inflammation
- Biosensors and Analytical Detection
- Cancer, Hypoxia, and Metabolism
- Drug Transport and Resistance Mechanisms
- Immune Cell Function and Interaction
- Nuclear Receptors and Signaling
- Thyroid Disorders and Treatments
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Retinal Development and Disorders
- Wnt/β-catenin signaling in development and cancer
- Liver physiology and pathology
- Immune cells in cancer
- 14-3-3 protein interactions
Wuhan University
2016-2018
Zhongnan Hospital of Wuhan University
2016-2018
Hubei Cancer Hospital
2017
Sichuan University
2012-2015
West China Hospital of Sichuan University
2013-2015
State Key Laboratory of Biotherapy
2012-2013
Baylor College of Medicine
1992-1997
Yale University
1997
The University of Texas Health Science Center at San Antonio
1997
Antihormones are potent antagonists of hormone action in vivo, but the mechanism underlying this antagonism is not understood. Several steroid hormones transform (activate) their receptors from a cytosolic, non-DNA binding 8 S sedimentation form to nuclear, DNA 4 form. Transformation accompanied by loss associated heat shock proteins. We have previously demonstrated that an additional hormone-dependent step, separate protein removal, required for activation human progesterone receptor....
The C terminus of nuclear hormone receptors is a complex structure that contains multiple functions.We are interested in the mechanism by which thyroid converts its receptor from transcriptional silencer to an activator transcription.Both regulatory functions localized ligand binding domain this superfamily member.In study, we have identified and characterized several functional domains within human (TR) conferring transactivation.Interestingly, these adjacent sites.One activation domain,...
Abstract Chemotherapies often induce drug-resistance in cancer cells and simultaneously stimulate proliferation activation of Myeloid-Derived Suppressor Cells (MDSCs) to inhibit anti-tumor T cells, thus result poor prognosis patients with breast cancers. To date, the mechanism underlying expansion MDSCs response chemotherapies is poorly understood. In present study, we used vitro cell culture vivo animal studies demonstrate that doxorubicin-resistant secret significantly more prostaglandin E...
Steroid, thyroid, and retinoid hormones exert their biological functions by interacting with cognate nuclear receptors. Upon binding receptors, induce a protease-resistant structural change in the receptor ligand-binding domain subsequently activate Utilizing partial proteolysis, we have been able to delineate region mouse X beta (mRXR beta) required for ligand binding. A separable activation within mRXR E has identified. The domain, which is 21 amino acids length, located at extreme C...
The retinoblastoma protein (Rb) plays a critical role in cell proliferation, differentiation, and development. To decipher the mechanism of Rb function at molecular level, we have systematically characterized number Rb-interacting proteins, among which is clone C5 described here, encodes 1,978 amino acids with an estimated mass 230 kDa. corresponding gene was assigned to chromosome 14q31, same region where genetic alterations been associated several abnormalities thyroid hormone response....
The role of hepatitis B virus (HBV) X protein (HBx) in the regulation HBV replication remains controversial. In present study, HBx regulating was initially investigated both HepG2 and Huh7 vitro cell lines with a transient transfection system. Next, regions responsible for transcriptional transactivation promotion were mapped an mouse model by vivo series expression plasmids. setting, deficiency had little effect on cells, but impaired cells. strong enhancing transcription replication. For...
The transcription factor Sox4 plays an indispensable role in the development of early progenitor B cells from hematopoietic stem cells. However, its B-cell acute lymphoblastic leukemia, a malignant counterpart normal cells, is not fully understood. Here we show that SOX4 highly expressed human leukemia To systematically study function established genetically defined mouse model by transforming carrying floxed allele and inducing deletion self-excising Cre recombinase. This allowed us to work...
The double nucleotide, A1762T and G1764A exchange (TA mutation), in the hepatitis B virus (HBV) genome basal core promoter (BCP) region is a common viral mutation patients with chronic HBV infection. This located binding site of hepatocyte nuclear factor 4 (HNF4), number liver‑enriched transcription factors are involved regulation replication. aim present study was to investigate biological characteristics strain this mutation, effect HNF4 inhibition on replication vivo. results indicated...
Early cancer diagnosis is of great significance to relative prevention and clinical therapy, it crucial efficiently recognize cancerous tumor sites at the molecular level. Herein, we proposed a versatile efficient strategy based on aptamer recognition photoactivation imaging for diagnosis. This first time that visible light-controlled photoactivatable aptamer-based platform has been applied The can accurately detect nucleolin-overexpressed cells be used highly selective cell screening tissue...
Objective To study the expression of Fibulin-5 in gastric cancer and its correlation with prognosis cancer. Methods Tissue chips from 90 cases were used to protein tissue para-carcinoma by immunohistochemistry, analyze clinical pathological characteristics. Results The was higher than that [cytoplasm: (6.2±4.2) vs. (5.1±3.7); nucleus: (7.2±3.8) (4.9±2.5), all P<0.05], which positively related patient′s age (r=0.213, P=0.044) cytoplasm cancerous tissue. The negatively overall...