A5049577134- Natural product bioactivities and synthesis
- Cancer-related molecular mechanisms research
- Lung Cancer Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Head and Neck Cancer Studies
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Immune cells in cancer
- Phytochemistry and Biological Activities
- Esophageal Cancer Research and Treatment
- Luminescence and Fluorescent Materials
- Synthesis of β-Lactam Compounds
- Cancer Cells and Metastasis
- Nutritional Studies and Diet
- Inflammatory mediators and NSAID effects
- Folate and B Vitamins Research
- Plant biochemistry and biosynthesis
- CAR-T cell therapy research
- Multiple Myeloma Research and Treatments
- Heavy Metal Exposure and Toxicity
- Arsenic contamination and mitigation
- Wound Healing and Treatments
- Phytochemical compounds biological activities
- Protein Degradation and Inhibitors
Zhejiang University
2020-2025
University of California, San Diego
2024-2025
Nantong University
2021-2025
Tongji University
2025
Hong Kong University of Science and Technology
2025
University of Hong Kong
2025
Bioscience (China)
2025
Textron Systems (United Kingdom)
2025
Second Affiliated Hospital of Xi'an Jiaotong University
2025
National University of Singapore
2021-2024
Nanoplastics are common contaminants in the living environment. Thus far, no investigations have focused on small intestinal injury offspring of adult mice that were exposed to nanoplastics through respiratory system during pregnancy. Here, we evaluated potential subjected maternal 80 nm polystyrene nanoparticle (PS-NP) exposure gestation. PS-NP significantly reduced birth weight female compared with male mice. However, body weights and substantially greater PS-NP-exposed groups....
Exposure to antimony (Sb), recently identified as a nerve pollutant, can result in neuron damage; but, associated-neurotoxicological mechanisms were still not clear. Herein, we assessed the role of ferroptosis Sb-mediated neurotoxicity and clarified underlying mechanism. Following Sb exposure, was significantly promoted vivo vitro. Moreover, following use ferrostatin-1 (fer-1) inhibit ferroptosis, Sb-induced PC12 cells effectively attenuated. accelerated lysosomal transport subsequent...
Objective: Using data from cancer registries to estimate thyroid incidence and mortality in China, 2015. Methods: Data submitted local were checked evaluated according the criteria of quality control, a total 368 registries' qualified for final analysis. stratified by area (urban/rural, eastern/central/western), sex age, combined with national population Results: Approximately 200,700 new cases diagnosed 2015, accounting 5.11% all cases. The crude rate was 14.60/100,000. Age-standardized...
Protein tyrosine phosphatases (PTPs) play major roles in cancer and are emerging as therapeutic targets. Recent reports suggest low-molecular weight PTP (LMPTP)-encoded by the
Abstract Recently mapped transcriptomic landscapes reveal the extent of heterogeneity in cancer‐associated fibroblasts (CAFs) beyond previously established single‐gene markers. Functional analyses individual CAF subsets within tumor microenvironment are critical to develop more accurate CAF‐targeting therapeutic strategies. However, there is a lack robust preclinical models that reflect this vitro. In study, single‐cell RNA sequencing datasets acquired from head and neck squamous cell...
In heterogeneous head and neck cancer (HNC), subtype-specific treatment regimens are currently missing. An integrated analysis of patient HNC subtypes using single-cell sequencing proteome profiles reveals an epithelial-mesenchymal transition (EMT) signature within the epithelial cancer-cell population. The EMT coincides with PI3K/mTOR inactivation in mesenchymal subtype. Conversely, is suppressed cells basal subtype which exhibits hyperactive signalling. We further identify YBX1...
Objectives The proportion of middle-aged and older adult people exposed to the Internet continues grow. use may have an impact on mental health adult, especially loneliness. This study analyzed relationship between presence Methods A total 550 person aged 45 years above were randomly selected from a province in eastern China at end 2022. outcome variable was loneliness, as measured by self-report. Descriptive analysis, chi-square test binary logistic analysis used analyze data. Results 58.3%...
Object detection involves the precise and efficient identification localization of multiple predefined object categories within images. With advent deep learning, both accuracy efficiency have significantly improved. Nevertheless, challenges remain in optimizing performance mainstream algorithms, improving small detection, enabling multi-class developing lightweight models. In response to these challenges, this paper provides a comprehensive literature review, analyzing approaches enhance by...
This study aimed to evaluate the cost-effectiveness of ASCT and maintenance therapy strategies for transplant-eligible patients with newly diagnosed multiple myeloma from a Chinese healthcare perspective. A short-run decision tree long-run Markov model were created assess mean costs quality-adjusted life-years (QALYs) plus over lifetime horizon. Utility values sourced published literature, while based on single-center retrospective analysis national drug bidding data. The strategy two-year...
As the number of randomized clinical trials (RCTs) demonstrating survival benefits combination therapies in previously treated multiple myeloma (MM) patients increases, it is essential to determine most cost-effective treatment through robust economic evaluation. This study aims assess cost-effectiveness for first/second-relapse MM from perspective Chinese healthcare system. A Markov model was developed evaluate three therapy groups based on primary drugs (bortezomib, lenalidomide, and...
Objective To describe the surgical steps in endoscopic malleostapedotomy as a primary intervention and to evaluate audiologic outcomes. Study Design Clinical capsule report. Setting University hospital. Patients Fourteen patients (10 males 4 females) who underwent between April 2017 July 2023 were enrolled this study. Demographic data, information, preoperative postoperative pure-tone averages air bone gaps, intraoperative complications, follow-up data summarized gathered database for...
Background The landscape of treatment strategies for relapsed/refractory multiple myeloma (RRMM) has dramatically changed due to the emergence chimeric antigen receptor T (CAR-T) cell therapy. aim this study was evaluate cost-effectiveness two CAR-T treatments RRMM patients from perspective Chinese healthcare system.Methods A Markov model used compare currently available salvage chemotherapy with Idecabtagene vicleucel (Ide-cel) and Ciltacabtagene autoleucel (Cilta-cel) RRMM. developed based...
含不同烷基链四苯基丁二烯衍生物的聚集诱导发光及力致变色性能 张璐璐 a 王媛媛 朱贵楠 b 戴文博 赵紫璇 赵盈 支俊格 * ,a 董宇平 ( 北京理工大学 化学与化工学院 北京 100871) 材料学院 摘要 设计合成了带有不同长度烷基链、不同极性取代基的四苯基丁二烯(TPB)衍生物 TPB-COOCH 3 -1～6 和 TPB-COOH-1～6, 目标化合物均具有显著的聚集诱导发光(AIE)特性及较高的固态荧光量子效率.烷基链长及取代基 极性都会影响目标化合物在聚集时分子排列及分子运动的受限程度, 从而调控其 AIE
ABSTRACT Objective Utilizing data from the National Health and Nutrition Examination Survey (NHANES) database, primary objective of this investigation was to examine relationship between dietary fiber intake (DFI) sleep disorders. Methods For analysis, three consecutive cycles NHANES (2009–2014) were pooled. The independent variable interest DFI, while dependent Weighted logistic regression employed model two variables. Subgroup analyses conducted, stratified, adjusted explore association...
Colorectal cancer (CRC) is one of the most common diseases worldwide, and telomere length has been reported correlate with CRC. This study aimed to investigate whether polymorphisms related genes are associated susceptibility CRC in Chinese Han population. 11 SNPs from TERT, TNIP1 OBFC1 were selected genotyped, addition odds ratio (OR) 95% confidence intervals (CI) used evaluate association between risk 247 patients clinically 300 controls a Our results showed that minor allele "G" rs7708392...
Objectives Few studies in China have focused on the economic evaluation of newborn screening (NBS) for inherited metabolic disorders (IMDs) by tandem mass spectrometry (MS/MS). This study assesses total costs, benefits, benefit–cost ratio (BCR), cost–utility (CUR) and incremental (ICUR) NBS using MS/MS compared to non-screened group. Methods The outcomes newborns who underwent IMDs 2009–2018 were retrospectively reviewed. Records extracted from a management system at Center Zhejiang...