Lin Chen

ORCID: 0000-0002-6453-7996
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About
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Research Areas
  • Colorectal Cancer Surgical Treatments
  • Gastric Cancer Management and Outcomes
  • Cancer-related molecular mechanisms research
  • Cancer Cells and Metastasis
  • Pancreatic and Hepatic Oncology Research
  • Anesthesia and Neurotoxicity Research
  • Lung Cancer Treatments and Mutations
  • Effects and risks of endocrine disrupting chemicals
  • Cancer Research and Treatments
  • Cancer, Hypoxia, and Metabolism
  • Salivary Gland Tumors Diagnosis and Treatment
  • Cancer, Lipids, and Metabolism
  • Diverticular Disease and Complications
  • Prostate Cancer Treatment and Research
  • Spaceflight effects on biology
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Genetic Associations and Epidemiology
  • Amoebic Infections and Treatments
  • Head and Neck Surgical Oncology
  • Cancer Immunotherapy and Biomarkers
  • Head and Neck Cancer Studies
  • Cancer Genomics and Diagnostics
  • Toxic Organic Pollutants Impact
  • Aortic Disease and Treatment Approaches
  • Aortic aneurysm repair treatments

Peking Union Medical College Hospital
2024-2025

Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025

Affiliated Hospital of Nantong University
2023-2025

Nantong University
2021-2025

Wenzhou Medical University
2025

Fujian Medical University
2002-2024

Chinese People's Liberation Army
2015-2024

Peking University
2014-2024

West China Medical Center of Sichuan University
2023-2024

Huazhong University of Science and Technology
2024

In recent years, the release of substantial amounts synthetic endocrine‐disrupting chemicals (EDCs) into environment has posed significant threats to human health. Among these EDCs, bisphenol A (BPA) and its substitutes, such as S (BPS), F (BPF), AF (BPAF), are widely used have been implicated in disrupting various biological processes. This research aimed evaluate potential link between bisphenol‐related gene expression lung cancer prognosis. Using Comparative Toxicogenomics Database (CTD),...

10.1155/jcpt/8872458 article EN cc-by Journal of Clinical Pharmacy and Therapeutics 2025-01-01

Disseminated tuberculosis (TB) presenting as miliary nodules on the gallbladder and liver is extremely rare poses significant diagnostic challenges. This report describes a case of disseminated TB discovered during emergency laparoscopic cholecystectomy for acute cholecystitis. A 77-year-old male presented with decreased appetite, weight loss, fever. Preoperative imaging suggested gallstones During surgery, multiple were found surfaces liver, raising suspicion metastatic cancer....

10.1186/s12245-025-00855-x article EN cc-by-nc-nd International Journal of Emergency Medicine 2025-03-03

In recent years, Bisphenol S (BPS) has increasingly been used as an alternative to A (BPA) in food, paper, and personal care products. It is imperative clarify the relationship between BPS tumors order treat prevent diseases. This study discovered a new method for predicting tumor correlations interactive genes. According analyses conducted by Gene Ontology Kyoto Encyclopedia of Genes Genomes, genes were primarily found gastric cancer. Based on gene-targeted prediction molecular docking,...

10.1016/j.ecoenv.2023.115054 article EN cc-by-nc-nd Ecotoxicology and Environmental Safety 2023-05-23

Fat4 functions as a Hippo signaling regulator which is involved in mammalian tissue development, differentiation and tumorigenesis. Loss of due to frequent gene mutation was detected variety tumors including gastric cancer, where recognized tumor suppressor, repressing cancer cell proliferation adhesion. However, the detailed mechanisms linking its diverse clinicopathological characteristics remain unclear. Here, we silenced using Fat4-shRNA cells found that this suppression led increase...

10.1080/15384047.2015.1108488 article EN Cancer Biology & Therapy 2015-11-17

Aberrant expression of stanniocalcin 2 (STC2) is implicated in cancer development. STC2 acts as a tumor promoter to drive some cancers. However, its contribution the development pancreatic remains unclear. This study showed that was significantly upregulated tissues. Moreover, positively correlated with size and lymph node metastasis negatively 5-year survival rate patients. Additionally, levels were novel biomarker for predicting overall after surgery. Furthermore, overexpression could...

10.1155/2019/8042489 article EN BioMed Research International 2019-07-15

Background. Gastric cancer is among the most common malignant tumors at home and abroad, because its early symptoms are mostly insidious, which leads to distant metastasis when gastric first diagnosed. The metastatic sites of mainly liver, lung, peritoneum, but bone relatively rare, prognosis very poor. Therefore, this study built on SEER database analyze related risk factors affecting patients, aiming improving clinicians’ understanding clinical diagnosis cancer, thus reducing misdiagnosis...

10.1155/2022/3251051 article EN cc-by Journal of Immunology Research 2022-02-15

Lung cancer is the most common malignant tumor type and it associated with poor prognosis. The identification of potential biomarkers great significance for early diagnosis treatment lung cancer. Non‑small cell (NSCLC) pathological present study aimed to investigate mechanism via which thyroid hormone receptor‑interacting protein 13 (TRIP13) participates in progression NSCLC. Immunohistochemistry, reverse transcription‑quantitative PCR western blotting were used assess expression level...

10.3892/or.2021.8123 article EN cc-by-nc-nd Oncology Reports 2021-06-28

Abstract Background and Aims Leisure sedentary behavior (LSB) is associated with the risk of cancer, but causal relationship between them has not been clarified. The aim this study was to assess potential association LSB 15 site‐specific cancers. Methods cancer were assessed univariate Mendelian randomization (UVMR) multivariate (MVMR). 194 SNPs (from UK Biobank 408,815 individuals) adopted as instrument variables. Sensitivity analyses performed ensure robustness results. Results UVMR...

10.1002/cam4.5974 article EN cc-by Cancer Medicine 2023-05-06

To explore the prognostic value of systemic inflammatory biomarkers (albumin/globulin ratio [AGR], neutrophil/lymphocyte [NLR], and platelet/lymphocyte [PLR]) in patients with oral squamous cell carcinoma (OSCC), further develop a novel score (AGR-NLR).A large-scale prospective study enrolling 792 eligible from December 2002 to June 2018 was carried out at First Affiliated Hospital Fujian Medical University. Three multivariate Cox regression models were performed assess association overall...

10.1111/odi.13774 article EN Oral Diseases 2021-01-15

To evaluate the safety, efficacy and outcomes of fast-track rehabilitation applied to gastric cancer proximal, distal total gastrectomy.Eighty consecutive patients undergoing resection performed by a single surgeon, received perioperative multimodal rehabilitation. Demographic operative data, gastrointestinal function, postoperative hospital stays, surgical general complications mortality were assessed prospectively.Of 80 (mean age 56.3 years), 10 (12.5%) proximal subtotal gastrectomy...

10.1186/1471-230x-14-147 article EN cc-by BMC Gastroenterology 2014-08-18

Evidence on serum arsenic and oral cancer risk was limited. We aimed to evaluate the association between of in a southeast China population.Serum determined for 325 patients 648 controls using inductively coupled plasma-mass spectrometry (ICP-MS). Logistic regression restricted cubic spline were analysed level risk, crude adjusted odds ratios (aOR) with 95% confidence interval (95% CI) calculated. Factors included age, gender, BMI, smoking, drinking, education, residence, marital status...

10.1111/cdoe.12633 article EN Community Dentistry And Oral Epidemiology 2021-03-21

This study aimed to evaluate the feasibility of total endovascular repair aortic arch in pigs using improved integrated double-branched stent grafts.Improved self-expandable grafts with a main body and two branches were prepared for six pigs. The these was evaluated arteriography, computed tomography (CT), angiography (CTA) autopsy three months following procedure.The placed successfully all All survived at least their biological behaviour normal. Arteriography, CTA animal necropsy revealed...

10.1308/003588413x13511609955814 article EN Annals of The Royal College of Surgeons of England 2013-03-01
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