A5101660487- Plant Molecular Biology Research
- Plant Gene Expression Analysis
- Genetic Mapping and Diversity in Plants and Animals
- RNA modifications and cancer
- Bioenergy crop production and management
- Cancer-related molecular mechanisms research
- Biosensors and Analytical Detection
- Plant biochemistry and biosynthesis
- Genetic and phenotypic traits in livestock
- Advanced biosensing and bioanalysis techniques
- Cancer-related gene regulation
- Supercapacitor Materials and Fabrication
- Plant Stress Responses and Tolerance
- Insect Resistance and Genetics
- Metabolomics and Mass Spectrometry Studies
- Plant Reproductive Biology
- Multimodal Machine Learning Applications
- Photosynthetic Processes and Mechanisms
- Cryptography and Data Security
- Natural Language Processing Techniques
- Cancer, Hypoxia, and Metabolism
- Domain Adaptation and Few-Shot Learning
- DNA Repair Mechanisms
- Cancer Mechanisms and Therapy
- Advanced battery technologies research
Jiangmen Central Hospital
2020-2025
Nanjing Agricultural University
2019-2024
Henan Agricultural University
2022-2024
Soochow University
2022-2023
Shanghai Jiao Tong University
2023
Beijing Forestry University
2018-2022
Second Affiliated Hospital of Zhejiang University
2016-2021
Nextomics Biosciences (China)
2021
Grandomics (China)
2021
University of Rochester
2021
Abstract Background Anti-angiogenic therapy represents a promising strategy for non-small-cell lung cancer (NSCLC) but its application in squamous cell carcinoma (SQC) is limited due to the high-risk adverse effects. Accumulating evidence indicates that long noncoding RNAs (lncRNAs) mediate tumor progression by participating regulation of VEGF NSCLC, which might guide development new antiangiogenic strategies. Methods Differential lncRNA expression SQC was analyzed AE-meta and TCGA datasets,...
Abstract Insect ryanodine receptors (RyRs) are the targets of diamide insecticides. Two point mutations G4946E and I4790M (numbering according to Plutella xylostella , PxRyR) in transmembrane domain insect RyRs associated with resistance have so far been identified three lepidopteran pests, P. Tuta absoluta Chilo suppressalis . In this study, we one known RyR target site (I4790M) a field‐collected population Spodoptera exigua The WF S. exhibited 154 fold chlorantraniliprole when compared...
Abstract Rosa rugosa , commonly known as rugged rose, is a perennial ornamental shrub. It produces beautiful flowers with mild fragrance and colorful seed pods. Unlike many other cultivated roses, R. adapts to wide range of habitat types harsh environmental conditions such salinity, alkaline, shade, drought, high humidity, frigid temperatures. Here, we produced analyzed high-quality genome sequence for understand its ecology, floral characteristics evolution. PacBio HiFi reads were initially...
Here, we provide mechanistic support for the involvement of CYP9A subfamily cytochrome P450 monooxygenases in detoxification host plant defense compounds and chemical insecticides Spodoptera exigua frugiperda . Our comparative genomics shows that a large cluster genes occurs two species but with significant differences its contents, including several species-specific duplicates substantial sequence divergence, both between orthologs duplicates. Bioassays CRISPR-Cas9 knockouts clusters show...
Abstract Background Rectal cancer is one of the most prevalent tumor types. Understanding metabolic profile rectal important for developing therapeutic approaches and molecular diagnosis. Methods Here, we report a metabonomics profiling tissue samples on large cohort human subjects (n = 127) normal controls 43) using 1 H nuclear magnetic resonance ( NMR) based assay, which highly sensitive non-destructive method biomarker identification in biological systems. Principal component analysis...
Abstract Background The biomarker identification of human esophageal cancer is critical for its early diagnosis and therapeutic approaches that will significantly improve patient survival. Specially, those involves in progression disease would be helpful to mechanism research. Methods In the present study, we investigated distinguishing metabolites tissues (n = 89) normal mucosae 26) using a 1 H nuclear magnetic resonance ( H-NMR) based assay, which highly sensitive non-destructive method...
Summary Lignin provides structural support in perennial woody plants and is a complex phenolic polymer derived from phenylpropanoid pathway. biosynthesis regulated by coordinated networks involving transcription factors ( TF s), micro RNA s (mi s) long noncoding (lnc s). However, the genetic underlying lignin pathway for tree growth wood properties remain unknown. Here, we used association genetics (additive, dominant epistasis) expression quantitative trait nucleotide eQTN ) mapping to...
Sustained activation of DNA damage response (DDR) signaling has been demonstrated to play vital role in chemotherapy failure cancer. However, the mechanism underlying DDR sustaining cancer cells remains unclear. In current study, we found that expression DDUP microprotein, encoded by CTBP1-DT lncRNA, drastically increased cisplatin-resistant ovarian and was inversely correlated cisplatin-based therapy response. Using a patient-derived human cell model, observed damage-induced foci sustained...
The beet armyworm, Spodoptera exigua, is a serious agricultural pest that primarily controlled using chemical insecticides. Recently, resistance to the insecticide spinosad has been described in S. exigua field populations. To date, there no functional evidence proving involvement of nicotinic acetylcholine receptor (nAChR) α6 mutation exigua.In this study, CRISPR/Cas9 genome-editing system, homozygous strain (Seα6-KO) with approximately 1760-bp deletion within Seα6 causing premature...
In the supercapacitor field, negative electrodes are mainly concentrated in carbon-based materials, such as activated carbon, carbon nanotubes, graphene, and so forth. However, materials based on metal-organic frameworks (MOFs) active components relatively rare. Herein, a series of composite graphene oxide (GO) vanadate-based Fe-organic have been prepared by hydrothermal method namely GO/Fe-VO
Lung adenocarcinoma (LUAD) is a highly malignant tumor with the highest mortality rate among all cancers. Early diagnosis and prognosis are important factors in treatment. Hepatic leukemia factor (HLF) thought to be closely associated lung cancer metastasis. It downregulated tissues negatively correlated number of metastasis-activating circulating cells (CTCs) peripheral blood patients. In this study, we analyzed data from LUAD samples TCGA found that HLF was significantly upregulated EGFR...
In perennial woody plants, the coordinated increase of stem height and diameter during juvenile growth improves competitiveness (i.e. access to light); however, factors underlying variation in remain unknown trees. Here, we used linkage-linkage disequilibrium (linkage-LD) mapping decipher genetic architecture three traits growth. We two Populus populations: a linkage population comprising full-sib family 1,200 progeny an association panel 435 unrelated individuals from nearly entire natural...
Long non-coding RNAs (lncRNAs) play essential roles in plant abiotic stress responses, but the response of lncRNA-mediated genetic networks to cadmium (Cd) treatment remain elusive trees, promising candidates for phytoremediation Cd contamination. We identified 172 Cd-responsive lncRNAs and 295 differentially expressed target genes leaves Cd-treated Populus tomentosa. Functional annotation revealed that these were involved various processes, including photosynthesis, hormone regulation,...