A5102800681- Thyroid and Parathyroid Surgery
- Thyroid Cancer Diagnosis and Treatment
- Head and Neck Anomalies
- Pancreatic function and diabetes
- Voice and Speech Disorders
- Pancreatic and Hepatic Oncology Research
- Airway Management and Intubation Techniques
- Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Genetics and Neurodevelopmental Disorders
- MicroRNA in disease regulation
- Immune cells in cancer
- Lung Cancer Treatments and Mutations
- Peptidase Inhibition and Analysis
- Hepatitis C virus research
- Pancreatitis Pathology and Treatment
- Hepatitis B Virus Studies
- Cannabis and Cannabinoid Research
- Neuroblastoma Research and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metabolism, Diabetes, and Cancer
- Circular RNAs in diseases
- Cancer Cells and Metastasis
- S100 Proteins and Annexins
- Cancer-related molecular mechanisms research
Zhujiang Hospital
2025
Southern Medical University
2018-2025
Second Affiliated Hospital of Zhejiang University
2014-2024
Henan University of Science and Technology
2024
Zhejiang University
2008-2023
Zhuzhou Central Hospital
2021-2022
RELX Group (Netherlands)
2022
Shanghai Institute of Pharmaceutical Industry
2020
National Natural Science Foundation of China
2008
Oxidative stress plays a pivotal role during the islet transplantation procedure, and antioxidant supplementation may protect grafts against oxidative injury. Chinese bayberry is one of six Myrica species native to China, we demonstrated here that anthocyanins from extract (CBE) pancreatic β cells (INS-1) hydrogen peroxide (H2O2)-induced necrosis apoptosis. Anthocyanins time- dose-dependently upregulated heme oxygenase-1 (HO-1) gene expression in primary islets. HO-1 knockdown increased...
Transoral endoscopic approach is the natural orifice surgery applied in thyroidectomy to achieve an excellent cosmetic result. Recurrent laryngeal nerve (RLN) injury most common complication and little advancement was achieved previous clinical studies of transoral thyroid surgery. Herein, we introduced method intraoperative neuromonitoring (IONM) for surgery.Patients with carcinoma received through vestibular (TOETVA) central node dissection (CND). IONM implemented identify whether RLN...
Objectives: Although changes of plasma fibrinogen have been documented in limited pancreatic malignant tumors, a relationship between and cancer large-scale clinical study has not shown. Methods: Preoperative levels were retrospectively analyzed 133 38 benign tumor patients. Results: Plasma patients significantly higher than those with (3.99 ± 1.01 vs 2.62 0.65; P < 0.001). The percentage hyperfibrinogenemia (>4.20 g/L) was 41.1%, no positive results obtained disease. increased advanced...
Intracerebral hemorrhage is the most dangerous subtype of stroke, characterized by high mortality and morbidity rates, frequently leads to significant secondary white matter injury. In recent decades, studies have revealed that gut microbiota can communicate bidirectionally with brain through microbiota-brain axis. This axis indicates closely related development prognosis intracerebral its associated The NACHT, LRR, pyrin domain-containing protein 3 (NLRP3) inflammasome plays a crucial role...
Abstract Background Remote access and endoscopic thyroid surgery has been gaining popularity because it allows patients to avoid a visible scar in the neck. There is limited data on transoral thyroidectomy when relates with papillary carcinoma. We aim evaluate safety of ipsilateral central compartment dissection for who undergo (thyroidectomy vestibular approach–compartment lymph node dissection). Patients Methods A total 80 underwent carcinoma from June 2015 September 2016 were identified....
Glarea lozoyensis is an important industrial fungus that produces the pneumocandin B0, which used for synthesis of antifungal drug caspofungin. However, because limitations and complications traditional genetic tools, G. strain engineering has been hindered. In this study, we established efficient CRISPR/Cas9-based gene editing tool in SIPI1208. With method, mutagenesis efficiency target locus can be up to 80%, enables rapid knockout. According reports, GloF Ap-HtyE, proline hydroxylases...
Superparamagnetic iron oxide nanoparticles (SPIO) are emerging as a novel probe for noninvasive cell tracking with magnetic resonance imaging (MRI) and have potential wide usage in medical research. In this study, we developed method using high-temperature hydrolysis of chelate metal alkoxide complexes to synthesize polyvinylpyrrolidone coated (PVP-SPIO), biocompatible agent that can efficiently label mice islet β-cells. The size, crystal structure properties the as-synthesized been...
// Cheng Xiang 1 , Mao-lin Zhang Qun-zi Zhao Qiu-ping Xie Hai-chao Yan Xing Yu Ping Wang Yong Department of Thyroid Surgery, Second Affiliated Hospital Medical College, Zhejiang University, Hangzhou, Province, China Correspondence to: Wang, email: surgwy@yeah.net Keywords: thyroid cancer, lncRNA, 131 I, PARP-1, SLC6A9-5:2 Received: September 16, 2016 Accepted: December 28, Published: January 10, 2017 ABSTRACT Recent studies have indicated that long non-coding RNAs play crucial roles in...
Abstract Background Transoral endoscopic thyroid surgery has been introduced in a few institutions. The purpose of this study was to present an innovative hybrid space‐maintaining method for the tri‐vestibular approach. Methods Eighteen consecutive patients underwent transoral thyroidectomy. Three incisions were made vestibule. surgical space maintained with CO 2 insufflation along suspension device. Thyroidectomy and central neck dissection (CND) performed safely effectively. Results mean...
A soluble decoy receptor 3 (DcR3), also known as TR6 or M68, is a member of the TNF family. It has been reported that high DcR3 expression occurs in many tumors.This prospective study evaluated tissue status by RT-PCR and its correlation with lymph node (N) stages 62 primary gastric cancers.DcR3 levels patients pN2-3 disease were much higher than those pN0-1 (median values 1.31 vs. 0, P < 0.01). Using ROC analysis, cutoff level at 1.20 was found to be associated optimal sensitivity...
To demonstrate the feasibility of intraoperative nerve monitoring (IONM) in total endoscopic thyroidectomy (TET) for high-risk thyroid cancer and to confirm its additional benefit on reducing surgery duration protecting recurrent laryngeal (RLN).One hundred twenty-three patients with or without autoimmune thyroiditis (AT) underwent TET using IONM not were included study. The primary outcome measures time used related procedures prevalence RLN injury.IONM could effectively reduce locating...
Bufalin, an active component of the Chinese medicine chan'su, has been reported to have inhibitory effect on growth various types cancer cells. In present study, we investigated whether gemcitabine combined with bufalin enhanced antitumor efficacy in pancreatic cancer. Three cell lines (Bxpc-3, Mia PaCa-2 and Panc-1) were treated and/or vitro. The combination treatment demonstrated greater inhibition cellular apoptosis. activity apoptosis signal-regulating kinase 1 (ASK1)/JNK was upregulated...
Ectogenic pancreatic islet transplantation has long been discussed as having the potential to reverse diabetes. The aim of present study was evaluate therapeutic efficacy co‑transplantation with hypoxia pretreated mesenchymal stem cells (MSCs) and islets in a diabetic mouse model. MSCs were isolated from femoral tibial bone marrow aspirates female BALB/c donor mice. MSC proliferation rates expression levels vascular endothelial growth factor A (VEGFA), interleukin (IL)‑6, monocyte...
Islets can be visualized on MRI by labeling with superparamagnetic contrast agent during the transplantation procedure. However, whether signal intensity reflects cell number and cellular viability has not been determined. We used a self‐synthesized novel –polyvinylpyrrolidone‐coated iron oxide nanoparticles (PVP‐SPIO) – to label β ‐TC‐6 cells (a mouse insulinoma line) or primary islets commercial Feridex as control. The efficiency of two agents was compared Prussian blue staining,...
Objective: To summarize the preliminary experience with transoral endoscopic thyroidectomy via vestibular approach (TOETVA). Methods: A total of 150 consecutive patients thyroid disease underwent TOETVA from November 2014 to February 2017 at Department Thyroid Surgery, Second Affiliated Hospital Zhejiang University School Medicine. The were comprised 138 females and 12 males. mean age was (31.7±7.6) years (ranging 15 51 years). There 108 differential carcinoma (T1 or T2 ≤3 cm, cN0 cN1a, M0)...