A5032499914- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Blood groups and transfusion
- Hematological disorders and diagnostics
- Platelet Disorders and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Mesenchymal stem cell research
- Blood disorders and treatments
- Immunodeficiency and Autoimmune Disorders
- Erythrocyte Function and Pathophysiology
- Multiple Myeloma Research and Treatments
- Bone and Joint Diseases
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Neutropenia and Cancer Infections
- Lymphoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Chronic Myeloid Leukemia Treatments
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cell Adhesion Molecules Research
- Cancer Genomics and Diagnostics
- Virus-based gene therapy research
Tianjin Medical University General Hospital
2016-2025
Tianjin Medical University
2014-2023
Second Hospital of Tianjin Medical University
2017-2023
Zhejiang University
2020
Weatherford College
2020
GLS-010 (zimberelimab) is a novel, fully human, anti-programmed death-1 monoclonal antibody that shows promising efficacy and safety in advanced solid tumors. This trial aimed to evaluate the of Chinese patients with relapsed or refractory classical Hodgkin lymphoma (r/r-cHL).This phase II, single-arm, open-label, multicenter clinical was conducted at 24 centers China enrolled r/r-cHL after two more lines therapy. The were administered intravenous (240 mg, once every 2 weeks) until...
The aim of the present study was to investigate number and function CD8+HLA-DR+ cells, which are considered be activated cytotoxic T lymphocytes (CTLs), in peripheral blood further examine pathogenesis severe aplastic anemia (SAA). Thirty-eight patients with SAA were included study. Patients screened for paroxysmal nocturnal hemoglobinuria by flow cytometry using anti-CD55 anti-CD59 antibodies. cells measured three-color anti-CD8-peridinin chlorophyll, anti-CD3-fluorescein isothiocyanate...
ABSTRACT Single‐cell sequencing of lineage negative (Lin‐) cells from patients with myelodysplastic syndromes (MDS) revealed a reduction in ferritin heavy chain 1 ( FTH1 ) levels, yet the significance this decrease pathophysiology MDS remains unclear. In study, we evaluated role MDS. The mRNA expression GlycoA + nucleated erythrocytes was significantly lower than that control group. implicated both ferritinophagy and ferroptosis patients, processes are linked to development anaemia. To...
Immune-related pancytopenia (IRP) is characterized by autoantibody-mediated destruction or suppression of bone marrow cells, leading to pancytopenia. This study aimed explore the role TRAPPC4 (trafficking protein particle complex subunit 4) as a key autoantigen in IRP, including epitope identification and immune activation mechanisms. A total 90 participants were included study, divided into four groups: 30 newly diagnosed IRP patients, 25 remission 20 patients with control hematologic...
Hepatitis-associated aplastic anemia (HAAA) is a variant of severe (SAA) in which bone marrow failure follows an acute attack hepatitis. Its pathogenesis poorly understood. We investigated the prevalence HAAA among cases newly diagnosed SAA presenting to our hospital between January 1998 and February 2013, analyzed clinical immune characteristics non-hepatitis-associated (non-HASAA) patients. The was 3.8% (36/949), majority patients (33/36) were seronegative for known hepatitis virus....
To assess the effectiveness of recombinant human thrombopoietin (rhTPO) in severe aplastic anemia (SAA) patients receiving immunosuppressive therapy (IST).Eighty-eight SAA IST from January 2007 to December 2012 were included this retrospective analysis. Of these, 40 subjects received rhTPO treatment (15000 U, subcutaneously, three times a week). was discontinued when platelet count returned normal range. Hematologic response, bone marrow megakaryocyte recovery, and time transfusion...
The objective of this study was to evaluate the efficacy and safety decitabine in Chinese patients with myelodysplastic syndrome (MDS). Patients (≥18 years) who had a de novo or secondary MDS diagnosis according French–American–British classification an International Prognostic Scoring System score ≥0.5 were enrolled randomized (1:1) one two regimens: 3-day treatment (3-h intravenous infusion 15 mg/m2 given every 8 h for three consecutive days/cycle/6 weeks) 5-day (1-h 20 once daily on days...
Resistance to bortezomib (BZ) is the major problem that largely limits its clinical application in multiple myeloma treatment. In current study, we investigated whether ClC5, a member of chloride channel family, involved this process. The MTT assay showed BZ treatment decreased cell viability three lines (ARH77, U266, and SKO-007), with IC 50 values 2.83, 4.37, 1.91 nM, respectively. Moreover, increased conversion LC3B-I LC3B-II expressions beclin-1 ATG5, concomitantly p62 expression....
To explore the effect of IL-6 on activity and secretory function B cells analyze its clinical indicators efficacy in wAIHA patients. This study included 25 hemolytic patients, 13 remission 10 HCs. Plasma levels various cytokines were detected using CBA. PBMCs extracted from 12 patients divided into three wells, stimulation with + tocilizumab, blank control wells also set. After 48 h vitro cell culture, percentage CD5+CD80+, CD5-CD80+,CD5+CD86+,CD5-CD86+,CD5+IL-10+,CD5-IL-10+B determined by...
To investigate the efficacy and safety of granulocyte transfusion combined with colony stimulating factor (G-CSF) in severe infection patients aplastic anemia (SAA).Fifty-six infections SAA who had received transfusions G-CSF from 2006 to 2012 our department were analyzed. A retrospective analysis was undertaken survival rates (at 30 days, 90 days 180 days), responses treatment 7 including microbiological, radiographic clinical responses), neutrophil count adverse events after...
Severe aplastic anemia (SAA) is an autoimmune disease in which bone marrow failure mediated by activated myeloid dendritic cells (mDCs) and T lymphocytes. Recent research has identified a strong immunomodulatory effect of pyruvate kinase M2 (PKM2) on immune‐mediated diseases. In this study, we aimed to explore the role PKM2 activation mDCs SAA. We observed conspicuously higher levels from SAA patients compared normal controls at both gene protein levels. Concurrently, unexpectedly discovered...
Previously, we described a group of patients with hemocytopenia who did not conform to diagnostic criteria known hematological and nonhematological diseases. Most responded well adrenocortical hormone and/or high-dose intravenous immunoglobulin treatment, indicating that cytopenia might be mediated by autoantibodies. Autoantibodies were detected on the membrane various bone marrow (BM) hemopoietic cells mononuclear-cell-Coombs test or flow cytometric analysis. Thus, was termed “Immunorelated...
Abnormal telomere attrition has been found to be closely related patients with SAA in recent years. To identify the incidence of and investigate relationship length clinical parameters, patients<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mo stretchy="false">(</mml:mo><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle="italic">27</mml:mn><mml:mo stretchy="false">)</mml:mo></mml:math>and healthy controls<mml:math id="M2"><mml:mo...
Thrombocytopenia is a common, often fatal complication experienced by patients with myelodysplastic syndromes (MDS). 5-aza-2'‑deoxycytidine (decitabine) has been used to treat MDS thrombocytopenia response rate of 45‑50%. However, the mechanism its effects on megakaryocytes remains unclear. In present study, effect decitabine megakaryocyte maturation was investigated. A total 20 diagnosed were enrolled, including 16 refractory anemia excess blasts (RAEB)‑1 and 4 RAEB‑2 patients], in addition...
Chimeric antigen receptor T (CAR-T) cells show good efficacy in the treatment of relapsed and refractory B-cell tumors, such as acute leukemia (ALL) diffuse large lymphoma (DLBCL). The main toxicities CAR-T include cytokine release syndrome, immune effector cell-associated neurotoxicity cytopenia, severe infection. It is still very difficult for to kill tumor maximum extent avoid damaging normal organs. Here, we report a case DLBCL with persistent grade 4 thrombocytopenia platelet...
Our goal was to detect the expression of CD96 and CD123 in myelodysplastic syndromes (MDS) their proliferation differentiation characteristics.Forty-three patients with MDS, thirteen AML diagnosed Hematology Department General Hospital Tianjin Medical University, sixteen healthy controls were enrolled this study. The expressions on CD34+CD38- bone marrow cells (BMC) these measured by FACS. CD114 (GCSFR), EPOR, CD110 (TPOR) CD34+CD38-CD96+ CD34+CD38-CD96- BMC cells' apoptosis (Annexin V) also...
Myelodysplastic syndromes (MDS) are clonal stem cell disorders characterized by ineffective hematopoiesis that lead to leukemia. Disorders of the immune system serve important functions in pathophysiology and progression this disease. Different levels or mechanisms natural killer (NK) cells patients with MDS have been measured previous studies, making it challenging understand pathogenesis NK cytotoxicity. The present study investigated frequency cell-mediated antibody-dependent cellular...
Severe aplastic anemia (SAA) is a primary disorder of severe bone marrow failure characterizing with extreme pancytopenia and profound diminution progenitor cells, which associated T cell hyper‑function. Abnormal telomere shortening mononuclear has been reported in AA, may lead to genomic instability, result senescence or apoptosis. Notably, certain studies identfieid that lymphocytes length have undergone apoptosis escape autoimmune diseases. In order investigate the association between...
Object: To explore the critical role of growth differentiation factor 11 (GDF11) in pathobiology aplastic anemia (AA). Methods: We have examined serum GDF11 levels for 79 AA patients and 30 healthy controls. A total patients, which included 29 new diagnosed (untreated) cases, 14 cases with no response, 21 partial remission (PR) 15 complete (CR) after immunosuppressive therapy (IST). were assessed by an enzyme-linked immunosorbent assay. mRNA expression peripheral blood mononuclear (PBMNC)...
Aplastic anemia results from bone marrow failure caused by an autoimmune abnormality, but the pathogenesis of severe aplastic (SAA) is not well characterized. To identify potential metabolic markers SAA and to further elucidate pathogenetic mechanisms SAA, we performed a metabolomic study plasma samples characterized intestinal microbiota patients with healthy controls. Patients had more Enterobacteriales Lactobacillales, fewer Bacteroidales, Clostridiales, Erysipelotrichales than At species...