A5100615479- Atherosclerosis and Cardiovascular Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related gene regulation
- Immune cells in cancer
- Blood disorders and treatments
- Cell Adhesion Molecules Research
- RNA Research and Splicing
- Protein Kinase Regulation and GTPase Signaling
- Wnt/β-catenin signaling in development and cancer
- Galectins and Cancer Biology
- RNA modifications and cancer
- Kruppel-like factors research
- Circular RNAs in diseases
- HER2/EGFR in Cancer Research
- Acute Kidney Injury Research
- Sepsis Diagnosis and Treatment
- Atrial Fibrillation Management and Outcomes
- IL-33, ST2, and ILC Pathways
- Immunotherapy and Immune Responses
- Cardiac Structural Anomalies and Repair
- Silk-based biomaterials and applications
- Cardiac Fibrosis and Remodeling
- Muscle Physiology and Disorders
- Genetic Associations and Epidemiology
- Biochemical and Structural Characterization
Hunan Provincial People's Hospital
2007-2025
Hunan Normal University
2018-2024
Hunan Provincial Center for Disease Control and Prevention
2024
Sun Yat-sen University
2019-2024
South China University of Technology
2015-2024
Tianjin Normal University
2024
Affiliated Hospital of Nantong University
2023-2024
Shanghai University
2023-2024
Nantong University
2023-2024
University of Science and Technology of China
2024
Objective Checkpoint immunotherapy unleashes T-cell control of tumours but is suppressed by immunosuppressive myeloid cells. The transmembrane protein MS4A4A selectively highly expressed in tumour-associated macrophages (TAMs). Here, we aimed to reveal the role + TAMs regulating immune escape tumour cells and develop novel therapeutic strategies targeting enhance efficacy checkpoint inhibitor (ICI) colorectal cancer. Design inhibitory effect blockade alone or combined with ICI treatment on...
Programmed death-1 receptor ligand 1 (PD-L1) is a promising therapeutic target in aggressive cancers. However, immune landscapes and cancer hallmarks of human PD-L1+ tumors as well their roles determining efficacies are unknown. Here, we showed, detailed studies gene data regarding 9769 patients 32 types cancers, that PD-L1 could not exclusively represent the IFN-γ signature potentially signified proinflammatory myeloid responses tumor. heterogeneity endowed by local controlled clinical...
First generation EGFR TKIs (gefitinib, erlotinib) provide significant clinical benefit for NSCLC cancer patients with oncogenic mutations. Ultimately, these patients' disease progresses, often driven by a second-site mutation in the kinase domain (T790M). Another liability of first drugs is severe adverse events inhibition WT EGFR. As such, our goal was to develop highly potent irreversible inhibitor largest selectivity ratio between drug-resistant double mutants (L858R/T790M, Del/T790M) and...
Abstract Background The immune system plays a vital role in the pathological process of ischaemic stroke. However, exact immune-related mechanism remains unclear. current research aimed to identify key genes associated with Methods CIBERSORT was utilized reveal cell infiltration pattern stroke patients. Meanwhile, weighted gene coexpression network analysis (WGCNA) meaningful modules significantly correlated characteristic were identified by following two machine learning methods: support...
Skeletal muscle atrophy is a common clinical feature of many acute and chronic conditions. Circular RNAs (circRNAs) are covalently closed RNA transcripts that involved in various physiological pathological processes, but their role remains unknown. Global circRNA expression profiling indicated circRNAs the pathophysiological processes atrophy. circTmeff1 identified as potential candidate influences It further highly expressed multiple types vivo vitro. Moreover, overexpression triggers vitro...
OBJECTIVE—Diabetes is caused by a deficiency of pancreatic β-cells that produce insulin. Approaches to enhance β-cell mass increasing proliferation and survival are desirable. We determined whether stromal cell–derived factor (SDF)-1/CXCL12 its receptor, CX chemokine receptor (CXCR)4, important for the β-cells. RESEARCH DESIGN AND METHODS—Mouse pancreata clonal were examined expression SDF-1 CXCR4, activation AKT downstream signaling pathways SDF-1, protection against apoptosis diabetes...
PI3K, AKT, and mTOR are key kinases from PI3K signaling pathway being extensively pursued to treat a variety of cancers in oncology. To search for structurally differentiated back-up candidate PF-04691502, which is currently phase I/II clinical trials treating solid tumors, lead optimization effort was carried out with tricyclic imidazo[1,5]naphthyridine series. Integration structure-based drug design physical properties-based yielded potent selective PI3K/mTOR dual kinase inhibitor...
The synthesis of enantiomerically pure 3-aryl substituted indanones is developed using an enantioselective sulfoxide-based Knoevenagel condensation/Nazarov cyclization procedure. After the reductive desulfonation methyl para-tolyl sulfoxide-containing chiral auxiliary under mild conditions, selected indanone used for divergent total syntheses three resveratrol natural products (+)-isopaucifloral F, (+)-quadrangularin A, and (+)-pallidol.
Ginsenoside-Rg1 (G-Rg1), a saponin that is primary component of ginseng, effective against inflammatory diseases. The P2X purinoceptor 7 (P2X7) receptor an ATP-gated ion channel predominantly expressed in immune cells and plays key role processes. We investigated the G-Rg1 sepsis-related cardiac dysfunction underlying mechanism involving regulation P2X7 receptor. detected cell viability, cytotoxicity, cellular reactive oxygen species (ROS) levels, mitochondrial membrane potential (MMP) with...
Abstract B cells secreting IL-10 functionally are recognized as functional regulatory (B reg ) cells; however, direct evidence concerning the phenotype, regulation, and clinical relevance of IL-10-secreting in humans is still lacking. Here, we demonstrate that, although itself anti-inflammatory, + patients with systemic lupus erythematosus (SLE) display aggressive inflammatory features; these features shift their functions away from inducing CD8 T cell tolerance cause them to induce a...
ObjectiveSepsis is the leading course of morbidity and mortality in critically ill patients. This study aimed to evaluate predictive value platelet aggregation for patients with sepsis. In addition, relationship between impaired mitochondria was explored.MethodThis a prospective, observational cohort study. The rate response adenosine diphosphate (ADP) assessed. primary outcome 28-day mortality. Platelet mitochondrial parameters, including triphosphate(ATP), membrane potential (MMP)...
RGS6 is a member of subfamily mammalian RGS proteins that possess DEP (disheveled, Egl-10, pleckstrin) and GGL (G protein γ subunit-like) domains in addition to the hallmark domain. negatively regulate heterotrimeric G signaling by virtue GTPase-activating activity their domains. exists multiple splice forms with long (6L) or short (6S) N terminus, complete incomplete domain, combination various C-terminal Green fluorescent protein-tagged RGS6L RGS6S exhibit predominantly cytoplasmic nuclear...
Abstract Background The immune system plays a vital role in the pathophysiology of acute myocardial infarction (AMI). However, exact related mechanism is still unclear. This research study aimed to identify key immune-related genes involved AMI. Methods CIBERSORT, deconvolution algorithm, was used determine proportions 22 subsets cells blood samples. weighted gene co-expression network analysis (WGCNA) modules that are significantly associated with Then, CIBERSORT combined WGCNA were...
The immune molecular mechanisms involved in ischaemic cardiomyopathy (ICM) have not been fully elucidated. current study aimed to elucidate the cell infiltration pattern of ICM and identify key immune-related genes that participate pathologic process ICM. differentially expressed (DEGs) were identified from two datasets (GSE42955 combined with GSE57338) top 8 DEGs related screened using random forest used construct nomogram model. Moreover, âCIBERSORTâ software package was determine...
Lipid metabolism plays an essential role in the genesis and progress of acute myocardial infarction (AMI). Herein, we identified verified latent lipid-related genes involved AMI by bioinformatic analysis. Lipid-related differentially expressed (DEGs) were using GSE66360 dataset from Gene Expression Omnibus (GEO) database R software packages. ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analyses conducted to analyze DEGs. two machine learning techniques: least...
RGS proteins are defined by the presence of a semiconserved domain that confers GTPase-activating activity these toward certain Gα subunits. RGS6 is member subfamily distinguished DEP and GGL domains, latter Gβ5-interacting domain. Here we report identification 36 distinct transcripts human arise unusually complex processing gene, which spans 630 kilobase pairs genomic DNA in chromosome 14 interrupted 19 introns. These use two alternative transcription sites splicing mechanisms encode with...
RGS proteins comprise a large family of named for their ability to negatively regulate heterotrimeric G protein signaling. RGS6 is member the R7 subfamily endowed with DEP (disheveled, Egl-10,pleckstrin) and GGL (G proteingamma subunit-like) domains in addition domain present all proteins. exists multiple splice variant forms identical but possessing complete or incomplete distinct N- C-terminal domains. Here we report that interacts SCG10, neuronal growth-associated protein. Using yeast...
RGS proteins negatively regulate heterotrimeric G protein signaling. Recent reports have shown that modulate neuronal, cardiovascular, and lymphocytic activity, yet their role in carcinogenesis has not been explored. In an epidemiologic study of 477 bladder cancer patients 446 matched controls, three noncoding single-nucleotide polymorphisms (SNPs) RGS2 RGS6 were each associated with a statistically significant reduction risk. The risk was reduced by 74% those individuals the variant...
The role of m6A in the regulation immune microenvironment atrial fibrillation (AF) remains unclear. This study systematically evaluated RNA modification patterns mediated by differential regulators 62 AF samples, identified pattern cell infiltration and several immune-related genes associated with AF. A total six key between healthy subjects patients were random forest classifier. Three distinct (m6A cluster-A, -B -C) among samples based on expression 6 regulators. Differential infiltrating...