A5100382707- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Cancer Immunotherapy and Biomarkers
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Glycosylation and Glycoproteins Research
- DNA and Nucleic Acid Chemistry
- Gut microbiota and health
- Nanoplatforms for cancer theranostics
- Bioactive Natural Diterpenoids Research
- Cancer Research and Treatments
- Catalysis and Oxidation Reactions
- Nanoparticle-Based Drug Delivery
- Ubiquitin and proteasome pathways
- Inflammatory Bowel Disease
- Urban Heat Island Mitigation
- Microtubule and mitosis dynamics
- Chronic Lymphocytic Leukemia Research
- Cancer, Stress, Anesthesia, and Immune Response
- Catalytic Processes in Materials Science
- PI3K/AKT/mTOR signaling in cancer
- Autophagy in Disease and Therapy
Shenzhen University
2015-2023
Shenzhen University Health Science Center
2018-2022
Zhengzhou University
2020
University of California, San Diego
2018
Tianjin Medical University
2015
Background and Aims: Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated immunomodulatory short‐chain fatty acids (SCFAs) derived from intestinal microbiota ILC3 regulation. Approach Results: We report that Lactobacillus reuteri was markedly reduced gut mice with HCC, accompanied by decreased SCFA levels, especially acetate....
Abstract B cells secreting IL-10 functionally are recognized as functional regulatory (B reg ) cells; however, direct evidence concerning the phenotype, regulation, and clinical relevance of IL-10-secreting in humans is still lacking. Here, we demonstrate that, although itself anti-inflammatory, + patients with systemic lupus erythematosus (SLE) display aggressive inflammatory features; these features shift their functions away from inducing CD8 T cell tolerance cause them to induce a...
Vaccines play increasingly important roles in cancer treatment due to their advantages of effective targeting and few side effects. Our laboratory has attempted construct vaccines by conjugating TLR7 agonists with tumor-associated antigens. Furthermore, immunochemotherapy recently become an appealing approach therapy. 5-fluorouracil (5-FU), a commonly used chemotherapeutic agent, can reportedly potently selectively kill MDSCs vivo. Gastric were synthesized the covalent attachment our agonist...
Mucin 1 (MUC1) has received increasing attention due to its high expression in breast cancer, which MUC1 acts as a cancer antigen. Our group been committed the development of small-molecule TLR7 (Toll-like receptor 7) agonists, have widely investigated field tumor immunotherapy. In present study, we constructed novel vaccine (SZU251 + Al) containing and two types adjuvants: agonist (SZU251) an aluminum adjuvant (Al). Immunostimulatory responses were first verified vitro, where promoted...
Adjuvant immunotherapy has recently emerged as a potential treatment strategy for breast cancer. The tumor‑associated protein mucin 1 (MUC1) received increasing attention due to its high expression in numerous types of common tumors, which MUC1 acts cancer antigen. However, the simple mixed composition an adjuvant and peptide is not sufficient rationale peptide‑based vaccine. present study developed novel Toll‑like receptor 7 (TLR7) agonist‑conjugated vaccine (T7‑MUC1), elicited effective...
Aspirin and isosorbide mononitrate (ISMN) are two commonly used drugs, which clinically applied for the treatment of inflammatory cardiovascular diseases, respectively. Recently, aspirin has attracted interest due to its potential application cancer, particularly colon cancer. NO-aspirin, an derivative containing a covalently bound NO-donating moiety, been proven be effective anti‑tumor agent with apoptosis-inducing ability. In present study, ISMN was as NO donor synergic effect assessed in...
In recent years, inhibitors of the BET bromodomain proteins, such as BRD4 inhibitors, have demonstrated robust antitumor activity. JQ-1, a representative small molecular inhibitor, is also effective to block PD-1/PD-L1 signaling by significantly decreasing PD-L1 expression on tumor cells. However, toxicity lymphoid and hematopoietic tissues limits their clinical usage. this research, we designed studied an immunogenic SZU-119, coupling JQ-1 with TLR7 agonist, SZU-101. vitro, SZU-119...
For an activating immunotherapy such as adjuvants, a compound that can prolong immune stimulation may enhance efficacy. We leveraged data from two prior high throughput screens with NF-
The use of large molecules for immunotherapy has led to exciting developments in cancer treatment, such as the development PD-1/PD-L1 antibodies. However, small molecule targeted therapies still lack effective immune-functional classes. Ideal anticancer drugs should simultaneously generate immune memory when killing cells prevent tumor relapse and metastasis. To this end, we carried out a rationally designed strategy develop novel classes compounds with bifunctional targeting...
Melanoma is a common and malignant cutaneous tumor, which responsible for large proportion of skin cancer deaths. Dendritic cell (DC)-based vaccines have achieved positive results in the treatment melanoma because their ability to induce cytotoxic response facilitate tumor elimination.To improve efficacy dendritic cell-based by adjuvant activity Helicobacter pylori neutrophil activating protein (HP-NAP).The recombinant HP-NAP (rHP-NAP) was expressed using prokaryotic expression system. DCs...
Solar shading is important in buildings for better indoor thermal/light environment and energy conservation, especially the tropical region. Compared with conventional windows additional fixed devices, adaptive self-shading functions take up less space require management labor. The present investigation focuses on a compact liquid-infill tunable window, which can provide colored according to surrounding environment. numerical model of window was established basis law mass enabled prediction...
Abstract As new treatment approaches, both immunotherapy and targeted treatments have been used in the clinical of cancers. These therapies are different from traditional surgery, chemotherapy radiotherapy. Use a combination may improve tumor clearance. We investigated feasibility combining tyrosine kinase inhibitors (TKIs, drugs) SZU-101 (a novel TLR7 agonist synthesized by our laboratory). Thirteen TKIs were combined with or without studied to determine their effects on immunocytes. On...
Oleandrigenin-3-O-β-D-diginoside (a derivative of odoroside A), isolated and purified by our group, has seldom been explored for its pharmacological activity. This study aimed at clarifying the mechanisms towards leukaemia-suppressive role A (compound #1) derivative, oleandrigenin-3-O-β-D-diginoside #2) from Nerium oleander. Viability nuclear morphology change were assessed CCK-8 assay fluorescence microscope, respectively. Then, cell apoptosis autophagy induced compounds detected flow...