A5056078692- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- Porphyrin and Phthalocyanine Chemistry
- Protein Degradation and Inhibitors
- Urban Transport and Accessibility
- Prenatal Screening and Diagnostics
- Corrosion Behavior and Inhibition
- melanin and skin pigmentation
- Sleep and Wakefulness Research
- Biochemical Analysis and Sensing Techniques
- Magnolia and Illicium research
- CAR-T cell therapy research
- Injury Epidemiology and Prevention
- Concrete Corrosion and Durability
- Memory and Neural Mechanisms
- Photodynamic Therapy Research Studies
- Tryptophan and brain disorders
- Nanoplatforms for cancer theranostics
- Phytochemicals and Antioxidant Activities
Shenzhen University
2023
Guangdong University of Technology
2019-2022
Shenzhen University Health Science Center
2020-2021
Hong Kong Polytechnic University
2019
Hebei North University
2013-2016
Chinese PLA General Hospital
2013-2014
Depression has been associated with reduced expression of brain-derived neurotrophic factor (BDNF) in the hippocampus. Previous studies have demonstrated that herbal medicine formula, ‘kaixinsan' (KXS), could ameliorate severity depression and increase cAMP response element-binding protein expression. There is direct evidence suggesting reduction BDNF specific brain sites can provoke depressive-like behaviour or affect neurogenesis vivo. However, biological mechanisms between antidepressant...
Kai-Xin-San (KXS) is a traditional Chinese medicine that has been widely used for the treatment of emotion-related disease. However, underlying mechanism remains largely unknown. The present study aimed to examine whether phospho-cAMP response element-binding protein (pCREB) and upstream components, such as extracellular signal-regulated kinase (ERK), phospho-ERK (pERK), phosphatidylinositol-3-kinase (PI3K), B (Akt), glycogen synthase 3β (GSK3β) pGSK3β are associated with antidepressive...
Compared with traditional liquid-liquid embedding method and solid-liquid of inclusion complexes β-cyclodextrin (β-CD) essential oil to form stable properties, the gas-liquid was applied encapsulate vaporized illicium verum (IvEO), β-CD as wall materials so that core molecules are in active state during complexing process. At optimal conditions a mass ratio 1:10, temperature 80°C, time 1 h, β-CD-IvEO (β-CD-IvEO-ICs) had an encapsulation efficiency (EE) 84.55 ± 2.31%. Fourier transform...
The present study aimed to evaluate the effect of kai xin san (KXS, at doses 500, 250, and 125 mg/kg body weight per day), a well-known traditional Chinese medicine, on learning memory in paradoxical sleep deprivation (PSD)-induced cognition deficit rats. Two behavior tests (the Open Field test Morris water maze task) were used for testing effects KXS PSD-induced model. Furthermore, its glutamic acid (GLU) γ-amino-butyric (GABA) levels brain tissue, brain-derived neurotrophic factor (BDNF),...
In recent years, inhibitors of the BET bromodomain proteins, such as BRD4 inhibitors, have demonstrated robust antitumor activity. JQ-1, a representative small molecular inhibitor, is also effective to block PD-1/PD-L1 signaling by significantly decreasing PD-L1 expression on tumor cells. However, toxicity lymphoid and hematopoietic tissues limits their clinical usage. this research, we designed studied an immunogenic SZU-119, coupling JQ-1 with TLR7 agonist, SZU-101. vitro, SZU-119...
Hydrosol is a natural aromatic product possessing broad application prospects as food preservative; however, limited information available regarding its anti-tyrosinase activity. Here, we investigated the inhibitory effects of Cinnamomum cassia Presl leaf hydrosol (CCPH) and Cymbopogon citratus (DC.) Stapf (CCSH) on tyrosinase The primary components CCPH CCSH were cinnamaldehyde (82.1%) citral (52.3%), respectively. compound, terpenoid, nitrogen oxide detectors within electronic nose yielded...
To investigate the effect of Dingzhixiao Wan (DZXW), a classic traditional Chinese medicine formula consisting Acorus tatarinowii, Polygala tenuifolia, Poria cocos and Panax ginseng in proportion 2: 3: 3, on learning-memory impairment induced by scopolamine its possible mechanisms.The mice were randomly divided into six groups: control group, model positive huperzine A (0.05 mg x kg(-1)) DZXW 700 kg(-1), 350 kg(-1) 175 groups. extracts orally administrated to for 7 days. Scopolamine (1.5 ip)...
Road traffic accidents in China result more than 50,000 fatalities annually. There are many risk factors that related to accidents, loss of lives and heavy property damage. Driver behavior was universally accepted as main reason for road accidents. This paper aims assess the impact illegal driver behaviors on with statistical data China. Firstly, correlation between different resulted four indices accident is analyzed. Secondly, indicators such numbers, fatality, injury, direct economic...
Photodynamic therapy (PDT) is a modern cancer therapy. But it still difficult to obtain ideal photosensitizers. We synthesized six new peri-xanthenoxanthene derivatives rapidly and efficiently using solid-phase carbon-bath microwave irradiation technology, investigated their in vitro photodynamic antitumor activity with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Our results showed that all compounds exhibited extremely low dark cytotoxicity good phototoxicity...
In this study, the effect of boric acid in cooling water system nuclear power plants on durability reinforced concrete was experimentally studied. The mechanical properties under solution environments were studied by accelerated test methods. addition, electrochemical behavior steel bar and microstructure results showed that corrosion does not affect to a large extent, as only occurs surface concrete, thus, internal still maintains high alkaline environment. At concentration 3%, products are...