A5101814772- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- RNA and protein synthesis mechanisms
- Luminescence and Fluorescent Materials
- Click Chemistry and Applications
- Synthesis and Biological Evaluation
- Metal complexes synthesis and properties
- Photoreceptor and optogenetics research
- Nanoplatforms for cancer theranostics
- Cancer therapeutics and mechanisms
- Molecular Junctions and Nanostructures
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Protein Degradation and Inhibitors
- Bioactive Compounds and Antitumor Agents
- Nanowire Synthesis and Applications
- interferon and immune responses
- 2D Materials and Applications
- CAR-T cell therapy research
- MXene and MAX Phase Materials
- Synthesis and bioactivity of alkaloids
- Photodynamic Therapy Research Studies
- Organic Light-Emitting Diodes Research
- Immune Cell Function and Interaction
Shenzhen University Health Science Center
2018-2025
Shenzhen University
2023-2025
Qilu University of Technology
2021
Shandong Academy of Sciences
2021
China University of Petroleum, Beijing
2020
Sun Yat-sen University
2013-2019
Guangzhou Experimental Station
2014
Multiple G-quadruplex units in the 3΄-terminal overhang of human telomeric DNA can associate and form multimeric structures. The specific targeting such distinctive higher-order G-quadruplexes might be a promising strategy for developing selective anticancer agents with fewer side effects. However, thus far, only few molecules were found to selectively bind G-quadruplexes, their effects on cancer cells unknown. In this study, new triaryl-substituted imidazole derivative called was...
Abstract Conventional chemotherapy remains the primary treatment option for triple-negative breast cancer (TNBC). However, current chemotherapeutic drugs have limited effects on TNBC, and often lead to serious side as well drug resistance. Thus, more effective therapeutic options are sorely needed. As c-MYC oncogene is highly expressed during TNBC pathogenesis, inhibiting expression would be an alternative anti-TNBC strategy. In this study, we designed synthesized a serial of quinoxaline...
Downregulating transcription of the oncogene c-MYC is a feasible strategy for cancer therapy. Stabilization G-quadruplex structure present in promoter can suppress transcription. Thus, far, several ligands targeting this have been developed. However, most shown no selectivity over other G-quadruplexes, leading to uncertain side effects. In study, through structural modification aryl-substituted imidazole/carbazole conjugates, brand-new, four-leaf clover-like ligand called IZCZ-3 was found...
The specificity of nucleic acids' binders is crucial for developing this kind drug, especially novel G-quadruplexes' binders. Quindoline derivatives have been developed as G-quadruplex stabilizers with good interactive activities. In order to improve the selectivity and binding affinity quindoline c-myc ligands, triazole containing benzofuroquinoline (T-BFQs) were designed synthesized by using 1,3-dipolar cycloaddition a series alkyne azide building blocks. toward DNA these T-BFQs was...
The specific sensing of an exact G-quadruplex structure by small molecules has never been reported. A fluorescent sensor based on the photoinduced electron transfer (PeT) mechanism provides possibilities for such specific, one-to-one recognition, indicated fluorescence. We have rationally developed a PeT IZFL-2 linking triarylimidazole and fluorescein moieties. is distinctive, smart whose fluorescence tunable its molecular conformations. then applied to G-quadruplexes found that it could...
Lung cancer is the malignant tumor with highest morbidity and mortality rate worldwide, of which non-small cell lung (NSCLC) accounts for approximately 85%. KRAS mutations are one significant mechanisms underlying occurrence, development, immune escape, chemotherapy resistance NSCLC. Two inhibitors approved by FDA treatment NSCLC in past three years. However, they only effective to G12C mutant, moreover, innate acquired drug already reported, leaving an urgent need block pathways through...
In this study, we designed and synthesized two compounds specifically for the detection of G-quadruplex (G4), a kind biologically relevant noncanonical nucleic acid structure. One them, NQ-1, with rigid linker, showed aggregation-induced emission (AIE) properties, while other one, NQ-2, flexible exhibited unfolding-intramolecular-aggregation-induced (UIA) characteristics. Our study demonstrated how adjusting linker rigidity can develop AIE UIA-based fluorescent probes G4.
A sensitive probe was developed for the detection of parallel G-quadruplexes without affecting their topology or thermal stability.
As c-MYC is one of the central players in triple-negative breast cancer (TNBC) oncogenesis, inhibiting expression would be an effective anticancer strategy. Transcription-induced negative supercoiling crucial regulation transcription, which facilitates formation a G4 structure NHE III1 that can silence transcription. However, topoisomerase 1 (Topo1) dissipate this supercoiling, leading to continuous activation Thus, dual ligands targeting both Topo1 and appear significant therapy. In study,...
Topoisomerases (Topo I and Topo II) are very important players in DNA replication, repair, transcription, a promising class of antitumor target. In present study, series benzo[a]phenazine derivatives with alkylamino side chains at C-5 were designed, synthesized, their biological activities evaluated. Most showed good antiproliferative activity range IC50 values 1–10 μM on the four cancer cell lines HeLa, A549, MCF-7, HL-60. Topoisomerase-mediated relaxation assay results that could...
A combination of platinum drugs with immunotherapy has shown promising anticancer effects, especially in the drug resistance cancer model. Herein, a new type immunochemotherapeutic was designed by tethering toll-like receptor 7 (TLR7) agonist on axial position oxaliplatin-based platinum(IV) prodrug. The prodrug simultaneously induced immunogenic cell death 4T1 cells to initiate an immune response and activate dendritic (DCs) secrete proinflammatory cytokines including interferon-γ (IFN-γ),...
G-quadruplexes (G4s) are potential drug targets in cancer treatment. However, the G4-targeted ligands seem to lack sufficient selectivity between tumors and normal tissues, appealing for a new modified anticancer strategy on basis of them. Type-1 photodynamic therapy (PDT) is promising possessing excellent spatiotemporal precision solid with hypoxic microenvironment. type-1 photosensitizers that target G4s induce situ photodamage have never been previously reported. In this study, we...
G-quadruplexes are higher-order nucleic acid structures that have attracted extensive attention because of their biological significance and potential applications in supramolecular chemistry. An ever-increasing interest has promoted the development selective sensitive fluorescent probes as research tools for these structures. However, most current studies primarily focus on improved selectivity G-quadruplexes. Their detection limits or ways to improve rarely described. In this study, a new...
Abstract Target-guided synthesis is an approach to drug discovery that allows the target self-assemble its own binding agents. So far, target-guided and especially in situ click chemistry have attracted extensive attention led identification of highly potent inhibitors for proteins. In this study, we expand application present a procedure using identify selective fluorescent probes specific topology G-quadruplex nucleic acids, parallel G-quadruplexes. On basis, compound 15 assembled by...