Abstract Nuclear factor erythroid 2-related 2 (Nrf2, also called NFE2L2) plays an important role in cancer chemoresistance. However, little is known about the of Nrf2 tumor mutation burden and effect modulating DNA mismatch repair (MMR) gene acute myeloid leukemia (AML). Here we show that expression associated with AML. Patients overexpression had a higher frequency drug resistance. protected AML cells from apoptosis induced by cytarabine vitro increased risk resistance vivo. Furthermore,...

There is increasing interest in experiences of urban forests because relevant studies have revealed that forest settings can promote mental well-being. The response to a experience be evaluated by facial expressions, but knowledge limited at large geographical scales. In this study, dataset 2824 photos, detailing the age (toddler, youth, middle-age, and senior citizen) gender visitors, was collected from Sina Weibo (a social media application similar Twitter China) between 1–7 October 2018,...

Urban forests are an important green infrastructure that positively impacts human well-being by improving emotions and reducing psychological stress. Questionnaires have been used frequently to study the influence of forest experiences on mental health; however, they poor controllability low accuracy for detecting immediate emotions. This alternative approach facial reading, expressions urban visitors their relationships with landscape metrics. Using microblogging site, Sina Weibo, we...

An outcome of building sustainable urban forests is that people’s well-being improved when they are exposed to trees. Facial expressions directly represents one’s inner emotions, and can be used assess real-time perception. The emergence change in the facial forest visitors an implicit process. As such, reserved character Asians requires instrument rating accurately recognize expressions. In this study, a dataset was established with 2,886 randomly photographed faces from at constructed park...

Andrographolide(ADE) has been demonstrated to inhibit tumor growth through direct cytotoxicity on cells. However, its potential activity microenvironment (TME) remains unclear. Tumor-associated macrophages (TAMs), composed mainly of M2 macrophages, are the key cells that create an immunosuppressive TME by secretion cytokines, thus enhancing progression. Re-polarized subpopulations may represent vital new therapeutic alternatives. Our previous studies showed ADE possessed anti-metastasis and...

Streetlamps enforce night lighting on urban forest trees, but scarce information is available concerning the ecophysiological performance of street trees under these conditions. In this study, maple ( Acer truncatum Bunge) and oak Quercus mongolica Fisch. ex Ledeb.) seedlings were cultured with simulated exposure to streetlamp spectra in white (red/green/blue, 7.7:1.0:2.2) red plus blue (RB; red/green/blue, 4.6:0.0:1.0) lights photosynthetic photon flux rate 80 μmol m -2 s -1 a 18-h...

Elucidating the cold tolerance mechanism of Paeonia lactiflora, which is one most valuable ornamental and medicinal plants in Asia, fundamentally impacts its breeding production. The glycerol-3-phosphate acyltransferase (GPAT) gene plays a pivotal role resistance variety plant species. Here, we cloned P. lactiflora GPAT gene, determined expression pattern, tested resistance. We obtained full-length using tissue-cultured seedlings real-time polymerase chain reaction rapid amplification cDNA...

The theory of lung being connected with large intestine, which is a major topic in Traditional Chinese Medicine (TCM), has guided clinical practice for thousands years China.In this study, we analyzed the history, main contents, application, and material basis theory, to attempt improve potential significance "lung intestine" China.The intestine was first described "Huang Di Nei Jing", formed one basic theories TCM. For years, majority TCM practitioners explored continuously, leading its...

Sea buckthorn ( Hippophae rhamnoides L.) is a berry bearing multiple nutritional properties. In this study, 46 compounds were isolated from sea berries. Preliminary data showed that the components, C13, C15, and C32, exhibited profound inhibitory effect on activation of hepatic stellate cells (HSCs) induced by transforming growth factor-β (TGF-β) decreased levels inflammatory factors. Furthermore, these over-regulated proteins DNA damage signaling pathway alpha-smooth muscle actin (α-SMA)....

Chinese external therapy (CET) is a topical application with mainly herb medicine thousands of years historical implications and clinical routine that commonly used for relieving joint-related symptoms in patients arthritis hospitals. However, there paucity modern medical evidence to support its effectiveness safety. Thus, we propose implement randomized, double-blinded, placebo-controlled trial rheumatoid (RA) using, as the experimental intervention, hospital-compounded gel preparation...

The present study collected cerebrospinal fluid samples from the corpus striatum in rats treated with borneol, moschus, storax, and acorus tatarinowii using brain microdialysis technology. Levels of excitatory neurotransmitters aspartic acid glutamate, as well inhibitory glycine γ-aminobutyric acid, were measured reversed-phase high-performance liquid chromatography, phosphate gradient elution, fluorescence detection. Results showed that concentrations all four amino significantly increased...

Ecological stoichiometry is an important index that reflects the element cycle and ecosystem stability. In this study, two sites (sunny shady slopes) five forest ages (young stage, half-mature near-mature mature over-mature stage) in a Pinus tabuliformis plantation were chosen to illustrate effects of site conditions on biomass stoichiometric characteristics leaves soils temperate mountainous area China. Except for young P. sunny slopes higher than those other ages, average carbon content...

To study the effect of classic ancient prescription Kaixin San (KXS) on learning and memory abilities in chronic stress depression model rats its possible mechanisms.Rats were randomly assigned to six groups: control group, positive drug group (fluoxetine 10 mg x kg(-1)) KXS groups (1000, 500, 250, 125 kg(-1)). orally administrated CMS for 21 days. The anti-depression activity was assessed using sucrose consumption open-field test. protecting Morris water maze (MWM) Furthermore, levels...

Poplar plantations can acclimate to drought stress in semi-arid areas, where the variation of stand age may result varied water adaptation strategies presented as hydrodynamic performance. In this study, nine mature Populus simonii Carr. individuals were targeted sampling objects characterized three ages: young (9 yr), middle-aged (17 and near-mature (29 yr) stages a area western Liaoning, Northeast China. Hydraulic traits investigated parameters leaf pressure-volume curves, xylem embolism...

To analyze the current status and development trends of patents spleen-invigorating health food with homology medicine in China, to provide ideas references for research traditional Chinese (TCM) food. The State Administration Market Regulation website's "Special Food Information Query Platform" incoPat global patent database were searched this study. Based on methods bibliometrics, registered related China sorted out. Furthermore, numbers, provinces, institutions, technology efficacy...

Carbon distribution in plants and ecological stoichiometry soils are important indicators of element cycling ecosystem stability. In this study, five forest ages, young (YF), middle-aged (MAF), near-mature (NMF), mature (MF), over-mature (OMF) a Pinus tabuliformis plantation were chosen to illustrate interactions among the C: N: P carbon plants, mountainous area eastern Liaoning, China. content was highest leaves MAF (505.90 g⋅kg −1 ) NMF (509.00 trunks YF (503.72 ), MF (509.73 OMF (504.90...

To investigate the effect of Dingzhixiao Wan (DZXW), a classic traditional Chinese medicine formula consisting Acorus tatarinowii, Polygala tenuifolia, Poria cocos and Panax ginseng in proportion 2: 3: 3, on learning-memory impairment induced by scopolamine its possible mechanisms.The mice were randomly divided into six groups: control group, model positive huperzine A (0.05 mg x kg(-1)) DZXW 700 kg(-1), 350 kg(-1) 175 groups. extracts orally administrated to for 7 days. Scopolamine (1.5 ip)...

Classification association rules that integrate with classification are playing an important role in data mining. However, the time cost on constructing model, and predicting new instances, will be long, due to large number of generated during mining rules, which also result system consumption. Therefore, this paper proposed a model based atomic applied it construct Tibetan medical syndrome for common plateau disease called Chronic Atrophic Gastritis. Firstly, introduce idea “relative...