A5100442369- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Memory and Neural Mechanisms
- Amino Acid Enzymes and Metabolism
- Stress Responses and Cortisol
- Olfactory and Sensory Function Studies
- Neuroendocrine regulation and behavior
- Polyamine Metabolism and Applications
- Vestibular and auditory disorders
- Alzheimer's disease research and treatments
- Nitric Oxide and Endothelin Effects
- Tryptophan and brain disorders
- Mitochondrial Function and Pathology
- Metabolomics and Mass Spectrometry Studies
- Neurological Disease Mechanisms and Treatments
- Metabolism and Genetic Disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Atherosclerosis and Cardiovascular Diseases
- Neurogenesis and neuroplasticity mechanisms
- Sleep and Wakefulness Research
- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Immune cells in cancer
- Neural dynamics and brain function
- Neuroscience of respiration and sleep
University of Otago
2014-2024
Qingdao National Laboratory for Marine Science and Technology
2017-2024
Brain Research New Zealand
2011-2024
Capital Medical University
2015-2024
Chinese Academy of Fishery Sciences
2017-2024
Beijing Tongren Hospital
2024
Ruijin Hospital
2024
Shanghai Jiao Tong University
2024
University of Electronic Science and Technology of China
2024
Zhejiang University
2023
Abstract Alzheimer’s disease (AD) is characterized as a distinct onset and progression of cognitive functional decline associated with age, well specific neuropathology. It has been discovered that glutamine (Gln) metabolism plays crucial role in cancer. However, full investigation its still missing. This study intended to find confirm potential Gln-related genes AD using bioinformatics analysis. The discovery GlnMgs was made possible by the intersection WGCNA test 26 Gln-metabolism...
Even though human sweat is odorless, bacterial growth and decomposition of specific odor precursors in it believed to give rise body humans. While mechanisms generation have been widely studied adults, little known for teenagers pre-pubescent children who distinct composition from immature apocrine sebaceous glands, but are arguably more susceptible the social psychological impact malodor. We integrated information whole microbiome analysis multiple skin sites (underarm, neck, head) time...
Rats with bilateral ibotenic acid lesions centered on the hippocampus (HPC) or perirhinal cortex (PRC) and sham-operated controls were tested in a series of object recognition spatial memory tasks. Both HPC PRC rats displayed reduced habituation novel environment impaired an object-location task. severely both reference working-memory versions water maze radial arm In contrast, although mild deficits version tasks, they markedly These findings demonstrate that under certain conditions play...
The inhibitory drive arising from the basal ganglia is thought to prevent occurrence of orienting movements eyes, head, and body in monkeys other mammals. direct projection substantia nigra pars reticulata (SNr) superior colliculus (SC) mediates inhibition. Since original experiments SNr buildup or prelude neuron has been a focus SC research. However, whether influences neurons unknown. Furthermore, contralateral SNr-SC pathway evident many species but remains unexplored alert monkey. Here...
Abstract Precursor ion scan and multiple reaction monitoring (MRM) are two typical modes in mass spectrometry analysis. Here, we developed a strategy by combining stable isotope labeling (IL) with liquid chromatography-mass (LC-MS) under double precursor (DPI) MRM for analysis of thiols 5 types human cancer urine. Firstly, the IL-LC-DPI-MS method was applied non-targeted profiling from samples. Compared to traditional full mode, DPI significantly improved identification selectivity accuracy....
Rats with bilateral, electrolytic lesions of perirhinal cortex (PRC), lateral entorhinal (LEC), or combined (PRLE) were impaired relative to controls (sham) during initial acquisition in the Morris water maze, although all groups eventually able learn locate platform. A further deficit performance PRC and PRLE, but not LEC groups, was evident, however, when a probe trial conducted 2 min (but 24 hours) after training. When sham- PRC-lesioned rats tested variable memory delays inserted between...
Abstract We investigated regional variations and the effects of aging on expression N ‐methyl‐ D ‐aspartate (NMDA) α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole (AMPA) receptor subunits in several memory‐associated structures using Western blotting. In young adult rats, NR1, NR2A, GluR2 levels varied between hippocampus parahippocampal region subregions hippocampus. When a comparison was made (4‐month‐old) aged (24‐month‐old) significant decreases NR1 were found ventral entorhinal postrhinal...
Abstract Agmatine is a metabolite of L ‐arginine by arginine decarboxylase. Recent evidence suggests that it exists in mammalian brain and novel neurotransmitter. The present study measured agmatine levels several memory‐associated structures aged (24‐month‐old), middle‐aged (12‐month‐old), young (4‐month‐old) male Sprague Dawley rats using liquid chromatography/mass spectrometry. were significantly decreased the CA1, but increased CA2/3 dentate gyrus, subregions hippocampus relative to...
Agmatine, a metabolite of L-arginine, is considered as novel putative neurotransmitter. It has been detected in axon terminals that synapse with pyramidal cells the hippocampus, brain region critically involved spatial learning and memory. However, role agmatine memory poorly understood. Recently, we demonstrated water maze training-induced increases tissue levels CA1 subregion hippocampus. This finding raised an issue whether endogenous could directly participate processes In present study,...
Our previous study demonstrated that microRNA-424 (miR-424) protected against experimental stroke through inhibition of microglial proliferation and activation by targeting cell cycle proteins. The purpose this was to further explore the clinical significance miR-424 in peripheral immune cells patients with acute ischemic (AIS). Blood samples were collected from 40 within 6 hours symptom onset 27 control subjects. MiR-424 levels lymphocytes, neutrophils plasma determined quantitative...
Background and Purpose T helper cell 1 (Th1)‐skewed neurotoxicity contributes to the poor outcome of stroke in rodents. Here, we have elucidated mechanism Th1/Th2 shift acute ischaemic (AIS) patients at hyperacute phase looked for a miRNA‐based therapeutic target. Experimental Approach MiR‐494 levels blood from AIS controls were measured by real‐time PCR. C57BL/6J mice subjected transient middle cerebral artery occlusion, cortical neurons oxygen–glucose deprivation. Luciferase reporter...
Abstract Objective Induced pluripotent stem cells (iPSCs) hold a promising potential for rescuing dopaminergic neurons in therapy Parkinson's disease (PD). This study clarifies TREM2‐dependent mechanism explaining the function of iPSC differentiation neuronal repair PD. Methods PD‐related differentially expressed genes were screened by bioinformatics analyses and their expression was verified using RT‐qPCR nigral tissues 6‐OHDA‐lesioned mice. Following ectopic depletion experiments iPSCs,...
Rats with bilateral electrolytic or ibotenic acid lesions that were centred in perirhinal cortex displayed a significant delay-dependent deficit on delayed nonmatch to position task the T maze. Although removal of prominent extramaze visual cues did not affect performance these rats, rotating maze between sample and test phases did, indicating rats using spatial strategy. Interestingly, further group hippocampal damage deficits may reflect dysfunction use inertial cues. These results suggest...