A5075958782- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Ferroptosis and cancer prognosis
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroscience and Neuropharmacology Research
- Advanced biosensing and bioanalysis techniques
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Molecular Sensors and Ion Detection
- Immune cells in cancer
- Plant Molecular Biology Research
- EEG and Brain-Computer Interfaces
- MicroRNA in disease regulation
- Plant nutrient uptake and metabolism
- Hedgehog Signaling Pathway Studies
- Face recognition and analysis
- Engineering Diagnostics and Reliability
- Video Surveillance and Tracking Methods
- Circular RNAs in diseases
- Nuclear Receptors and Signaling
- RNA Interference and Gene Delivery
- Vestibular and auditory disorders
- Neural dynamics and brain function
- Cholesterol and Lipid Metabolism
- Reliability and Maintenance Optimization
University of Electronic Science and Technology of China
2022-2024
Sichuan University
2017-2023
Chinese Academy of Sciences
2023
State Key Laboratory of Biotherapy
2022
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2022
Nanchang University
2019
First Affiliated Hospital of Nanchang University
2019
Central China Normal University
2014-2018
Wuhan National Laboratory for Optoelectronics
2015
Huazhong University of Science and Technology
2012-2015
PHOSPHATE STARVATION RESPONSE1 (PHR1) is a key regulatory component of the response to phosphate (Pi) starvation. However, regulation PHR1 in this remains poorly understood. Here, we report that target transcription factors AUXIN RESPONSE FACTOR7 (ARF7) and ARF19 positively regulated by auxin signaling Arabidopsis (Arabidopsis thaliana) roots. expression was induced exogenous suppressed transport inhibitors In promoter, three auxin-response elements, which are bound directly ARF7 ARF19, were...
More than 15 million out of 70 patients worldwide do not respond to available antiepilepticus drugs (AEDs). With the emergence nanomedicine, nanomaterials are increasingly being used treat many diseases. Here, we report that tetrahedral framework nucleic acid (tFNA), an assembled nanoparticle, showed excellent ability cross blood-brain barrier (BBB) inhibit M1 microglial activation and A1 reactive astrogliosis in hippocampus mice after status epilepticus. Furthermore, tFNA inhibited...
Ferroptosis is implicated in a range of brain disorders, but it unknown whether neurons or glia the are particularly effected. Here, we report that primary cortical astrocytes (PA), microglia (PM), and (PN) varied their sensitivities to ferroptosis. Specifically, PM were most sensitive ferroptosis, while PN relatively insensitive. In contrast, equally susceptible apoptosis, with PA being less affected, whereas all three cell types similarly autophagic death. tri-culture system containing PA,...
Alzheimer's disease is a neurodegenerative caused by excessive amyloid β protein-induced neurotoxicity. However, drugs targeting protein production face many problems, such as the low utilization rate of cells and difficulty in penetrating blood-brain barrier. A tetrahedral framework nucleic acid new type nanonucleic structure that functions therapy drug carrier. Here, we synthesized BACE1 aptamer-modified tested its therapeutic effect on vitro vivo. Our results demonstrated could be used...
Abstract Objective Induced pluripotent stem cells (iPSCs) hold a promising potential for rescuing dopaminergic neurons in therapy Parkinson's disease (PD). This study clarifies TREM2‐dependent mechanism explaining the function of iPSC differentiation neuronal repair PD. Methods PD‐related differentially expressed genes were screened by bioinformatics analyses and their expression was verified using RT‐qPCR nigral tissues 6‐OHDA‐lesioned mice. Following ectopic depletion experiments iPSCs,...
Resistance to traditional antiepileptic drugs is a major challenge in chronic epilepsy treatment. MicroRNA-based gene therapy promising alternative but has demonstrated limited efficacy due poor blood-brain barrier permeability, cellular uptake, and targeting efficiency. Adenosine an endogenous antiseizure agent deficient the epileptic brain elevated adenosine kinase (ADK) activity reactive A1 astrocytes. We designed nucleic acid nanoantiepileptic drug (tFNA-ADKASO@AS1) based on tetrahedral...
Overexpression of Sonic hedgehog (Shh) is associated with progression several cancers. The expression Shh in non-small cell lung cancer (NSCLC) has been reported inconsistent results. Lung adenocarcinoma (LAC) and squamous carcinoma (LSCC) are two major subtypes NSCLC, which have different genetic genotypes clinical therapeutic options. specimen patients NSCLC yet to be comprehensively determined according histological subtypes. level was 167 (56 LAC 111 LSCC patients) by immunohistochemical...
Abstract Intracerebral hemorrhage (ICH) is a type of stroke with high morbidity and mortality. Activation microglia in response to ICH can lead neuroinflammation, which further exacerbate brain damage neuronal death. By integration single-cell RNA sequencing (scRNA-seq) spatial transcriptome (ST) technologies rat model, we demonstrated that subtype (MIkzf1) strong expression Ikzf1 exhibits stage-specific around the damaged region. MIkzf1 expressed neuroinflammatory factors markedly drove by...
Dear Editor, After intracerebral hemorrhage (ICH), significant inflammatory response and neuronal damage are evident.1 Inflammatory factors induce apoptosis, which is the main cause of dysfunction.2 Although exosomes (Exo) being studied as a treatment for dysfunction, their crucial mechanisms have remained unknown.3, 4 This study investigated essential by Exo alleviates dysfunction post-ICH. First, we confirmed that post-Exo, brain inflammation ICH-rats were significantly improved (Figure...
The anterior lateral motor cortex (ALM) is critical to subsequent correct movements and plays a vital role in predicting specific future movements. Different descending pathways of the ALM are preferentially involved different roles However, circuit function mechanisms these may be concealed anatomy circuit. Clarifying inputs should provide some helpful information for elucidating mechanisms. Here, we used retrograde trans-synaptic rabies virus systematically generate, analyze, compare whole...
Traditional sedation management consists of doctors adjusting the dosage sedative drugs or adding other in combination according to evaluation nurses; nurses then execute orders. The nurses' passive execution process is not ideal model for continuous and observation sedation. This study aims investigate application effects nurse-provided procedural analgesia patients intensive care unit.The experimental group consisted 354 heart surgery who received from November 2020 August 2021. control...
Performance degradation; Time series; Reliability prediction; Non-stationary data. Abstract. degradation model has become a critical issue for lifetime reliability research. A novel n-ARIMA-based equipment performance method was proposed in this paper. First of all, general process analyzed detail. Then non-stationary Auto-Regression Integrated Moving Average adopted to set up the model, and an equation calculate level also built. Finally, validation experiment implemented on OTM650 milling...
Face attribute analysis, which is a challenging and popular task in the vision field, has been widely used various fields including intelligent security, human-computer interaction, targeted promotion. However, practical applications, people are not always facing camera, their head postures would affect accuracy of prediction. In addition, some attributes inherently more difficult to predict due image noise, motion blur, light variation. To improve face self-supervised Siamese multi-task...