A5101992955- Cancer-related Molecular Pathways
- Autophagy in Disease and Therapy
- Reproductive Biology and Fertility
- RNA modifications and cancer
- Reproductive System and Pregnancy
- Liver Disease Diagnosis and Treatment
- Ovarian function and disorders
- Invertebrate Immune Response Mechanisms
- RNA Interference and Gene Delivery
- Neonatal Respiratory Health Research
- Aquaculture disease management and microbiota
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer Cells and Metastasis
- Effects and risks of endocrine disrupting chemicals
- Cancer Research and Treatments
- Pluripotent Stem Cells Research
- Colorectal and Anal Carcinomas
- Autoimmune Bullous Skin Diseases
- RNA Research and Splicing
- Nuclear Receptors and Signaling
- Adipokines, Inflammation, and Metabolic Diseases
- Bacteriophages and microbial interactions
- Neonatal and fetal brain pathology
Guangxi Medical University
2019-2025
Guangzhou Medical University
2021-2025
Second Hospital of Yichang
2016-2025
China Three Gorges University
2018-2025
Xian Yang Central Hospital
2024-2025
Southwest Jiaotong University
2025
Jishou University
2023-2024
Nanjing Medical University
2021-2024
Suzhou Municipal Hospital
2020-2024
Sixth Affiliated Hospital of Sun Yat-sen University
2018-2023
Abstract Ischemic stroke represents a significant danger to human beings, especially the elderly. Interventions are only available remove clot, and mechanism of neuronal death during ischemic is still in debate. Ferroptosis increasingly appreciated as cell after ischemia various organs. Here we report that serine protease, thrombin, instigates ferroptotic signaling by promoting arachidonic acid mobilization subsequent esterification gene, acyl-CoA synthetase long-chain family member 4...
Background One measurement of hs‐CRP (high‐sensitivity C‐reactive protein) is associated with increased risk cardiovascular disease ( CVD ). The objective this study was to characterize the association cumulative exposure hs‐ CRP incident events. Methods and Results We included 53 065 participants measured at 3 examinations in 2006, 2008, 2010. Cumulative calculated as weighted sum average level for each time interval (level×time). Participants were classified into nonexposed group (hs‐...
Abstract Female fecundity declines in a nonlinear manner with age during the reproductive years, even as ovulatory cycles continue, which reduces female fertility, disrupts metabolic homeostasis, and eventually induces various chronic diseases. Despite this, aging‐related cellular molecular changes human ovaries that occur these years have not been elucidated. Here, single‐cell RNA sequencing (scRNA‐seq) of is performed from different childbearing ages reveals activation pyroptosis pathway...
Ferroptosis is implicated in a range of brain disorders, but it unknown whether neurons or glia the are particularly effected. Here, we report that primary cortical astrocytes (PA), microglia (PM), and (PN) varied their sensitivities to ferroptosis. Specifically, PM were most sensitive ferroptosis, while PN relatively insensitive. In contrast, equally susceptible apoptosis, with PA being less affected, whereas all three cell types similarly autophagic death. tri-culture system containing PA,...
Abstract Genetic diseases encompass a spectrum of disorders resulting from DNA variations. Preimplantation genetic testing (PGT) is critical strategy for preventing recurrent miscarriage, foetal malformations, and the birth children affected by chromosomal abnormalities monogenic disorders. Traditional PGT techniques necessitate comprehensive pedigree data haplotype linkage analysis, whereas employing third-generation sequencing (TGS) has distinct advantages, particularly in cases incomplete...
This study aimed to explore the risk factors for early intraventricular hemorrhage (IVH) in extremely low birth weight infants (ELBWIs) provide guidance intervention, thereby improving survival rates and quality of life these vulnerable infants. A retrospective was conducted on 205 ELBWIs admitted Women Children's Medical Center Guangzhou University from January 2019 December 2023. Standard head ultrasound screening (HUS) used assess presence severity IVH days 1–3 5–7 post-birth. Infants...
Abstract: Long non-coding RNAs (lncRNAs) refer to RNA molecules that exceed 200 nucleotides in length. While lncRNAs do not possess the capacity encode proteins, they play crucial roles gene expression, chromatin remodeling, and protein relocation. PSMA3 antisense 1 (PSMA3-AS1) is a newly discovered lncRNA located on human chromosome 14q23.1. Convincing evidence shows it acts as tumor-promoting factor several forms of cancers. Moreover, high expression PSMA3-AS1 linked poor clinical...
Long non-coding RNAs (lncRNAs) are a type of RNA with length more than 200 nucleotides. They do not encode proteins but crucial in regulating gene expression and affecting the malignant biological behavior cancer. Small nucleolar host 10 (SNHG10) is novel lncRNA that plays regulatory role many tumors. Several recent studies have shown SNHG10 aberrantly expressed various forms This instability closely related to important tumorigenic processes, such as cell proliferation, migration, invasion,...
BACKGROUND Colon cancer is a common malignancy of the digestive tract. An estimated 1148515 new cases colon were reported in 2020 worldwide. Chronic myeloid leukemia (CML) malignant tumor formed by clonal proliferation bone marrow hematopoietic stem cells, with an annual incidence rate 1-2 per 100000 people Leukemia can be secondary to solid tumors, and vice versa . Reports on CML tumors account for 8.7% but extremely rare. Therapy-related rare potentially fatal adverse event chemotherapy or...
Liver dysfunction has been known to occur frequently in cases of sepsis. Excessive inflammation and apoptosis are pathological features acute liver failure. Recent studies suggest that activation glycogen synthase kinase- (GSK-) 3 β is involved apoptosis. We aimed investigate the protective effects GSK-3 inhibition on polymicrobial sepsis-induced injury explore possible mechanisms. Polymicrobial sepsis was induced by cecal ligation puncture (CLP), SB216763 used inhibit C57BL/6 mice....
Abstract Metastasis is a critical factor for the high mortality of colorectal cancer (CRC), but its mechanism not completely understood. Epithelial-mesenchymal transition (EMT) thought to play key role in metastasis and also increases stem cell (CSC) feature that facilitates metastatic colonization. In this study, we investigated biological roles DAB2IP regulating EMT cell–like features human CRC. We demonstrate suppresses NF-κB-mediated CSC CRC cells. knockout mice, discovered hyperplasia...
Background The respiratory syncytial virus (RSV) is the main cause of bronchiolitis in infants and interferon (IFN) α a commercial antiviral drug. nebulization IFN α1b could be viable treatment method. In this study, therapeutic effects safety delivery via infant were investigated multi-center prospective study. Methods findings Bronchiolitis patients admitted to 22 hospitals who met inclusion criteria enrolled randomly allocated four groups: control, Intramuscular Injection, Nebulization 1...
<b><i>Background and Objectives:</i></b> This study was to characterize the association of cumulative exposure increased high-sensitivity C-reactive protein (hs-CRP) with chronic kidney diseases (CKD). <b><i>Methods:</i></b> We included 35,194 participants hs-CRP measured at three examinations in 2006, 2008, 2010. Participants were classified into nonexposed group (hs-CRP &#x3c;3.0 mg/L all 3 examinations), 1-exposed ≥3.0 1 2-exposed 2...
In this study, we prepared gold nanostar (GNS) composite nanoparticles containing siRNA of cyclooxygenase-2(siCOX-2) that were modified by tumor targeting ligand 2-deoxyglucose (DG) and transmembrane peptide 9-poly-D-arginine (9R) to form siCOX-2(9R/DG-GNS). Paclitaxel loaded temperature sensitive liposomes (PTX-TSL) surface-modified produce PTX-TSL-siCOX-2(9R/DG-GNS) displaying homogeneous star-shaped structures suitable size (293.93 nm ± 3.21) zeta potentials (2.47 mV 0.22). had a high...