A5100358195- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Congenital Heart Disease Studies
- Hepatitis C virus research
- Influenza Virus Research Studies
- Animal Disease Management and Epidemiology
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Pharmacological Effects of Natural Compounds
- Lipid metabolism and disorders
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Stability and Control of Uncertain Systems
- Long-Term Effects of COVID-19
- Cardiac Arrhythmias and Treatments
- Liver physiology and pathology
- Mechanical Circulatory Support Devices
- Viral Infections and Vectors
- Cardiovascular and Diving-Related Complications
- HIV/AIDS drug development and treatment
- Virology and Viral Diseases
Shandong Provincial Hospital
2008-2025
Shandong First Medical University
2021-2025
Capital Medical University
2025
Center for Children
2024
Tianjin Medical University
2012-2024
Tianjin First Center Hospital
2012-2024
Jianghan University
2009-2023
Yangzhou University
2023
China National Pharmaceutical Group Corporation (China)
2018-2023
Hubei University of Chinese Medicine
2023
At present, coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome 2, is spreading all over the world, disastrous consequences for people of countries. The traditional Chinese medicine prescription Dayuanyin (DYY), a classic treatment plague, has shown significant effects in COVID-19. However, its specific mechanism action not yet been clarified. This study aims to explore DYY COVID-19 hope providing theoretical basis clinical application.First, TCMSP...
There is a large body of evidence showing that delayed initiation sepsis bundle associated with adverse clinical outcomes in patients sepsis. However, it controversial whether electronic automated alerts can help improve Electronic databases are searched from inception to December 2021 for comparative effectiveness studies comparing versus usual care the management A total 36 eligible analysis, including 6 randomized controlled trials and 30 non-randomized studies. significant heterogeneity...
Seasonal influenza epidemics cause serious public health problems in China. Search queries-based surveillance was recently proposed to complement traditional monitoring approaches of epidemics. However, developing robust techniques search query selection and enhancing predictability for remains a challenge. This study aimed develop novel ensemble framework improve penalized regression models detecting by using Baidu engine data from The applied combination bootstrap aggregating (bagging)...
In recent years, novel cardiometabolic biomarkers and related pathogenic genes their heritability have been examined. However, no multitarget predictive evaluation models exist can identify predict complex lesions in unstable angina (UA) the early stages before coronary angiography (CAG) or evaluate prognosis of patients with UA lesions. this study, we sought to investigate correlation between blood lipid, glucose, inflammatory indices occurrence lesions, also risk factors for major adverse...
Transcatheter closure of perimembranous ventricular septal defects in children is a highly effective procedure, but it can result tricuspid regurgitation (TR). The associated risk factors and long-term outcomes TR following the procedure are not well understood. This retrospective study included 1343 pediatric patients (age, 4.41±2.56 years) who underwent successful transcatheter defect between 2002 2022, with median follow-up 78 (range, 12-244) months. was evaluated using echocardiography,...
Background: Globally, of the 248 million people chronically infected with hepatitis B virus (HBV), 74 reside in China. Five oral nucleot(s)ide analogs (NUCs) have been approved for treatment chronic (CHB) China.Objectives: The aims this study were to determine rates adherence NUC therapy patients CHB, identify self-perceived barriers adherence, and examine factors associated adherence.Methods: Questionnaire-based interviews administered among Chinese CHB at hepatology clinics a tertiary...
Background In children, the practice of transcatheter closure intracristal ventricular septal defect (icVSD) has been limited. Currently, there is a lack comparison between device perimembranous (pmVSD) and icVSD, long-term clinical outcomes are rare. Methods Results This study included total 633 children (39 with icVSD 594 pmVSD), aged 18 months to 16 years, who underwent January 2014 December 2018. All patients were followed up until September 2020, median follow-up 46 in pmVSD group 52...
H9N2 are widespread and have sporadically caused clinical diseases in humans. Extensive vaccinations poultry helped constrain H9N2; however, they might facilitated the evolution of virus.
The genotypes of the H9N2 avian influenza viruses have changed since 2013 when almost all circulating in chickens China were genotype 57 (G57) with fittest lineage each gene. To characterize variant from 2011 to 2014, 28 isolated live poultry markets 2011–2014 and analyzed by genetic biological characterization. Our findings showed that 16 residues antigenicity, two potential N-linked glycosylation sites, one amino acid receptor binding site HA protein significantly 2011–2014. Moreover, NA...
Some immune escape mutants of H9N2 virus and the corresponding mutations in hemagglutinin (HA) have been documented, but little is known about impact a single mutation on antigenicity pathogenesis H9N2. In this study, seven critical sites HA associated with were identified effects (N166D) derived from mutant (m3F2) investigated. Although N166D did not significantly affect viral replication Madin-Darby canine kidney (MDCK) cells shedding larynx cloaca chicken, attenuated mice. Compared to...
Abstract In less than 6 months, COVID-19 spread rapidly around the world and became a global health concern. Hypertension is most common chronic disease in patients, but its impact on these patients has not been well described. this retrospective study, 82 diagnosed with were enrolled, epidemiological, demographic, clinical, laboratory, radiological therapy-related data analyzed compared between (29 cases) or without (53 hypertension. The median age of included was 60.5 years, cohort 49...
Currently, transcatheter closure of perimembranous ventricular septal defect (pmVSD) is a widely accepted therapeutic modality. However, arrhythmias, especially postprocedural heart blocks, are concern and outcomes not very clear. This study explored the risk factors arrhythmias associated with device pmVSD.A total 395 patients diagnosed pmVSD who successfully underwent intervention between January 2010 December 2015 in our center were retrospectively reviewed. Electrocardiographic data...
This study aims to observe the clinical characteristics of recovered patients from Coronavirus Disease 2019 (COVID-19) with positive in reverse transcription-polymerase chain reaction (RT-PCR) or serum antibody. The profile, symptoms, laboratory outcomes, and radiologic assessments were extracted on 11 patients, who tested for COVID-19 RT-PCR antibody after discharged was admitted Hubei No. 3 People's Hospital Jianghan University a second treatment March 2020. average interval time between...
Three series of novel macrolactams and macrolactones--12-alkoxyimino-tetradecanlactam, 12-alkoxyiminopentadecanlactam, 12-alkoxyiminodecanlactone derivatives (7A, 7B, 7C)--were synthesized from corresponding 12-oxomacrolactams 12-oxomacrolactone. Their structures were confirmed by 1H NMR elemental analysis. The Z E isomers 7A 7B separated, their configurations determined NMR. These compounds showed fair to excellent fungicidal activities against Rhizoctonia solani Kühn. It is interesting...
Hepatocellular carcinoma (HCC) is among the leading causes of cancer deaths in China. Considering its poor prognosis when diagnosed late, Chinese guidelines recommend biannual screening for HCC with abdominal ultrasound and serum α-fetoprotein (AFP) test high-risk populations.To investigate practice, knowledge, self-perceived barriers hospital patients China.An interview-based questionnaire was conducted chronic hepatitis B and/or C infection from outpatient clinics at 2 tertiary medical...
Abstract Objective The objective of this study was to explore the clinical effect transcatheter closure congenital perimembranous ventricular septal defect using Amplatzer duct occluder 2. Methods Between February 2012 and December 2016, 51 patients were subjected 2 for defect. A total with who underwent by conventional membranous comprised control group. success rate complications compared, indications explored. Results interventional procedure 98.0% (50/51) in group versus 100% occluder....
<b><i>Background and Objectives:</i></b> This study was to characterize the association of cumulative exposure increased high-sensitivity C-reactive protein (hs-CRP) with chronic kidney diseases (CKD). <b><i>Methods:</i></b> We included 35,194 participants hs-CRP measured at three examinations in 2006, 2008, 2010. Participants were classified into nonexposed group (hs-CRP &#x3c;3.0 mg/L all 3 examinations), 1-exposed ≥3.0 1 2-exposed 2...
Liver ischemia/reperfusion injury (LIRI) is a common complication of liver surgery, and affects function post‑transplantation. However, the precise mechanism underlying LIRI has not yet been completely elucidated. Previous studies have demonstrated involvement number microRNAs (miRNAs/miRs) in pathophysiology. The objective present study was to determine potential miR‑101‑mediated regulation autophagy LIRI. Compared with sham‑treated group, significant decrease miR‑101 mechanistic target...
Potential differences in complications and/or long-term outcomes of perimembranous ventricular septal defect (pmVSD) closures with 3-mm waist vs. 4-mm double-disk symmetrical occluders are not known.