A5100776868- RNA modifications and cancer
- Congenital heart defects research
- Cancer-related gene regulation
- COVID-19 and healthcare impacts
- Epigenetics and DNA Methylation
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Thyroid Disorders and Treatments
- Mitochondrial Function and Pathology
- IL-33, ST2, and ILC Pathways
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Electronic Packaging and Soldering Technologies
- Connexins and lens biology
- Congenital Heart Disease Studies
- Inflammasome and immune disorders
- Estrogen and related hormone effects
- Studies on Chitinases and Chitosanases
- Protein Hydrolysis and Bioactive Peptides
- Nanocomposite Films for Food Packaging
- Toxoplasma gondii Research Studies
- Nitric Oxide and Endothelin Effects
- Nuclear Receptors and Signaling
- Advanced Biosensing Techniques and Applications
- Intraocular Surgery and Lenses
Jianghan University
2020-2024
Hubei Zhongshan Hospital
2013-2022
Wuhan University
2013-2022
Qingdao University
2009-2022
Affiliated Hospital of Qingdao University
2015-2022
Hainan University
2021-2022
Xinxiang Medical University
2020
Huazhong University of Science and Technology
2011
Louis Stokes Cleveland VA Medical Center
2009
State Key Laboratory of Oncogene and Related Genes
2009
Recent studies have shown that microRNA-21 (miR-21) contributes to tumor resistance chemotherapy. Interestingly, we found berberine could inhibit miR-21 expression in several cancer cell lines. In this study, investigated whether modulate the sensitivity of ovarian cells cisplatin and explored mechanism. The cisplatin-resistant SKOV3 were incubated with combined had a significantly lower survival than alone group enhanced cisplatin-induced apoptosis. Berberine function cancer, as by an...
This study aims to observe the clinical characteristics of recovered patients from Coronavirus Disease 2019 (COVID-19) with positive in reverse transcription-polymerase chain reaction (RT-PCR) or serum antibody. The profile, symptoms, laboratory outcomes, and radiologic assessments were extracted on 11 patients, who tested for COVID-19 RT-PCR antibody after discharged was admitted Hubei No. 3 People's Hospital Jianghan University a second treatment March 2020. average interval time between...
Abstract In less than 6 months, COVID-19 spread rapidly around the world and became a global health concern. Hypertension is most common chronic disease in patients, but its impact on these patients has not been well described. this retrospective study, 82 diagnosed with were enrolled, epidemiological, demographic, clinical, laboratory, radiological therapy-related data analyzed compared between (29 cases) or without (53 hypertension. The median age of included was 60.5 years, cohort 49...
Abstract Accumulated evidence suggests that quercetin, a dietary flavonoid, has beneficial effects in protection against cardiovascular diseases and the inhibition of tumour growth. We have recently shown antioxidants such as 17β-estradiol, resveratrol, dithiothreitol vitamin C activate membrane-bound guanylate cyclase GC-A, receptor for atrial natriuretic factor (ANF). Since quercetin is phytoestrogen potent antioxidant, it possible may GC-A or other isoforms. examined whether activates...
To analyze the clinical phenotype and genetic etiology of a child with Multiple congenital anomalies-hypotonia-seizures syndrome 1 (MCAHS1).
Cyclophilin A (CypA), a receptor for the immunosuppressive agent cyclosporin A, is cis-trans-peptidyl-prolyl isomerase (PPIase). It accelerates cis-trans isomerization of prolyl-peptide bonds. CypA binds and regulates activity variety proteins. Atrial natriuretic factor (ANF) its membrane-bound guanylate cyclase-A (GC-A) are involved in regulation blood pressure. We examined whether affects activation GC-A by ANF. The results showed that associated with GC-A. Interestingly, binding ANF to...
The aim of this study was to investigate the correlation between H-ras mutation and primary hepatocellular carcinoma (HCC) describe role in carcinogenesis. Clinical samples 69 patients were collected expression levels HCC surrounding normal tissues examined using HotStarTaq PCR. further analyzed PCR direct sequencing method. results showed that present 49 (49/69, 71.01%), which 19 had codon 40 mutated from CTA CTG 30 61 GGC AGC. By contrast, only 2 mutations found tumor-adjacent tissues....
Journal Article The rs7517847 polymorphism in the IL-23R gene is associated with gout a Chinese Han male population Get access Shiguo Liu, Liu Shandong Provincial Key Laboratory of Metabolic Disease, Affiliated Hospital Medical College, Qingdao University, Qingdao, P. R. ChinaInstitute Clinical Research, ChinaGenetic Laboratory, China Search for other works by this author on: Oxford Academic Google Scholar Hongmei He, He Renchao Yu, Yu Department Cardiology, Lin Han, Correspondence to:...
The clinical manifestations of thyroid diseases in elderly patients are often atypical. This study aimed to establish reference intervals for function the order help diagnose this population. A total 5345 healthy individuals were examined and divided into three groups according their age: 4297 aged < 65 years (19–64), 719 between 79 years, 329 80 100 years. Levels free triiodothyronine (FT3), thyroxine (FT4), thyroid-stimulating hormone (TSH), peroxidase antibody, thyroglobulin antibody...
Abstract Background As a rare mitochondrial disease, combined oxidative phosphorylation deficiency 14 (COXPD14) is caused by biallelic variants in the phenylalanyl-tRNA synthetase 2, gene ( FARS2 ) with clinical features of developmental delay, an elevated lactate level, early-onset encephalopathy, liver failure, and hypotonia. The objectives this study were to analyze molecular two Chinese siblings affected COXPD14, review relevant literature. Methods Mutation screening was performed whole...
This paper discusses the thermo-mechanical design and analysis of a large die FCBGA. work focuses on co-design 1 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">st</sup> level 2 xmlns:xlink="http://www.w3.org/1999/xlink">nd</sup> solder joint reliability flip chip package emphasizing effect details substrate modeling layout design. Model with all layered structures for build up is compared compact model equivalent substrate. The fatigue life...
Prediction and reduction of substrate warpage is very important to enhance assembly yield, improve reliability in the microelectronic packaging industry. Modeling copper trace pattern a difficult time consuming task. these patterns are often too complex for FEM model exactly, so steps taken reduce number elements computation necessary with FEM. An used approach use micromechanics considerations find effective material properties layers mixed dielectric material. This yields isotropic based...
This study was aimed to investigate the effects of DNA methylation inhibitor 5-aza-2'-deoxycytidine (5-Aza-CdR) and histone deacetylase trichostatin A (TSA) on DLC-1 gene transcription regulation molecular biological behaviours in human multiple myeloma RPMI-8226 cells. The cells were treated respectively with 5-Aza-CdR TSA alone, or both combination; cell proliferation apoptosis, expression, protein expression Ras homolog family member (RhoA) Ras-related C3 botulinum toxin substrate 1...
Oestrogen is known to exert both genomic and non-genomic effects on target tissues. Unlike the effects, identity of receptors mediating oestrogen remains controversial. 17beta-estradiol has been shown activate membrane-bound guanylate cyclase GC-A in PC12 cells a manner. To examine whether exerts similar effect other cell types, we measured tamoxifen, an anti-oestrogen, activity porcine kidney proximal tubular LLC-PK1 cells. increased cGMP levels Interestingly, addition tamoxifen also...
To identify association of IL18-607 C/A and -137 G/C polymorphism with susceptibility to gout in Chinese Han male population, We evaluate the genetic contribution 202 patients 493 gout-free control population by allele-specific polymerase chain reaction assay. Our results reveal no significant between polymorphisms -607C/A -137G/C IL18 gout. study might suggest that -607 promoter are not associated thus do play a major role development population.
To decrease the fishy odor of tilapia protein hydrolysates, this study investigated flavor properties fish hydrolysates (FPH) fermented by Hanseniaspora pseudoguilliermondii (FPHY), Lactobacillus plantarum 082 (FPHL) and combined fermentation (FPHLY). The thiobarbituric acid reactive substance (TBARS) values FPHY (from 3.15 mg/L to 2.30 mg/L) FPHL 2.89 1.29 reduced 26.98% 55.36%, respectively. However, there were no obvious changes in amino composition. HS-SPME-GC-MS analysis showed that...