A5010798876- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Protein Degradation and Inhibitors
- Heterotopic Ossification and Related Conditions
- Ginseng Biological Effects and Applications
- Alkaline Phosphatase Research Studies
- Histone Deacetylase Inhibitors Research
- Lipid metabolism and disorders
- Peptidase Inhibition and Analysis
- Traditional Chinese Medicine Analysis
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Parathyroid Disorders and Treatments
Nantong University
2018-2020
Targeting vascular endothelial growth factor (VEGF) using small interfering RNA (siVEGF) has shown great potential in inhibiting the growth, proliferation, and migration of tumors by reducing proliferation blood vessels. On basis bionic principles, a novel pH-responsive virus mimetic shell-sheddable chitosan (CS) micelles (CMs) as siRNA delivery system was introduced this study. The cyclo(Arg-Gly-Asp-d-Phe-Lys) (cRGD) modified poly(enthylene glycol) (PEG) conjugated to HA2 via hydrazone...
The key for better antitumor efficacy is to improve the specificity of drugs tumor cells and diminish their cytotoxicity normal tissues. Targeted nanoparticles as drug delivery system can resolve this problem. In study, we prepared folate TAT (arginine-rich cell-penetrating peptide) modified N-PEG-N'-octyl-chitosan form folate/TAT-PEG-OC micelles. Then, molecular structure, morphology, size distribution bio-safety micelles were characterized. order investigate drug-loading capacity micelles,...
In this study, we prepared gold nanostar (GNS) composite nanoparticles containing siRNA of cyclooxygenase-2(siCOX-2) that were modified by tumor targeting ligand 2-deoxyglucose (DG) and transmembrane peptide 9-poly-D-arginine (9R) to form siCOX-2(9R/DG-GNS). Paclitaxel loaded temperature sensitive liposomes (PTX-TSL) surface-modified produce PTX-TSL-siCOX-2(9R/DG-GNS) displaying homogeneous star-shaped structures suitable size (293.93 nm ± 3.21) zeta potentials (2.47 mV 0.22). had a high...
Objective To evaluate whether the combination of pan-histone deacetylase (HDAC) inhibitor, suberanilohydroxamic acid (SAHA), and cyclooxygenase-2 (COX-2) celecoxib, could produce synergistic anticancer effects in human salivary adenoid cystic cancer (SACC) cells. Methods SACC cells were treated with COX-2 inhibitor celecoxib or pan-HDAC SAHA, a for 24 hours. Cell proliferation, apoptosis, migration invasion evaluated using cell counting kit 8 (CCK-8) assay, 4',6-diamidino-2-phenylindole...