A5101999542- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Aluminum toxicity and tolerance in plants and animals
- Curcumin's Biomedical Applications
- Biomarkers in Disease Mechanisms
- Pharmacological Effects of Medicinal Plants
- RNA Research and Splicing
- Natural product bioactivities and synthesis
- Insect and Pesticide Research
- Bryophyte Studies and Records
- Pesticide Exposure and Toxicity
- Ecology and Conservation Studies
- Trace Elements in Health
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Caveolin-1 and cellular processes
- Environmental Toxicology and Ecotoxicology
- Pharmacological Effects of Natural Compounds
- Fern and Epiphyte Biology
- Fungal Biology and Applications
- Phytochemistry and biological activity of medicinal plants
- Heavy Metal Exposure and Toxicity
- Plant Pathogens and Fungal Diseases
Affiliated Hospital of Youjiang Medical University for Nationalities
2020-2022
Anhui Medical University
2020
Youjiang Medical College for Nationalities
2020
First Affiliated Hospital of Anhui Medical University
2020
Henan University Huaihe Hospital and Huaihe Clinical Institute
2018
Jishou University
2006-2017
Air Force Medical University
2015
Xijing Hospital
2015
Yunnan University of Traditional Chinese Medicine
2006-2012
Weatherford College
2010
Hepatocellular carcinoma (HCC) is one of the leading causes cancer death worldwide. Endoplasmic reticulum stress (ERS) generally activated in HCC and important for sensitivity to anticancer drugs. ERS-dependent autophagy a crucial mechanism affecting drugs, but by which ERS regulates not well understood. Zinc finger protein 263 (ZNF263) transcription factor member zinc family. However, its functional role remains be studied. In current study, we investigated ZNF263 regulating ERS-induced...
Abstract Background and Objectives Increasing studies report that lncRNAs are dysregulated in hepatocellular carcinoma (HCC), which might function as significant diagnostic biomarkers of HCC. LncRNA MSC‐AS1 has been newly discovered several cancers. However, its biological effect HCC remains to be clearly elucidated. The aim our work was test expression level assess progression. Methods Expression levels PGK1 were tested by qRT‐PCR cells including HUH‐7, BEL‐7404, SNU449, HepG2, QGY‐7701,...
More and more findings illustrate the critical roles of circular RNA (circRNA) in diabetes mellitus (DM) its complications. A major pathological characteristic for DM is apoptosis endothelial cells (ECs) induced by high glucose (HG), however, function circRNA ECs' phenotypes still elusive. Here, this study identified an up-regulated (circVEGFC) HG-induced human umbilical vein (HUVECs). Functionally, knockdown circVEGFC alleviated recovered proliferation HUVECs HG administration....
The occurrence and development of diabetes seriously threaten the health patients.Therefore, mechanism exploration is great significance for more effective control this disease.In study, we aimed to investigate regulatory miR-139-5p Notch signaling pathway on liver damage oxidative stress in diabetic mice.The mouse model was established, mice were divided into normal group, negative (NC) mimic inhibitor DAPT + group.The mRNA expressions miR-139-5p, Notch1, Jagged1, NICD1, protein NICD1...
Aluminum (Al), the most common element in nature, can enter body through various routes. Unfortunately, excessive accumulation of Al cause chronic toxicity. In this study, rats were randomly allocated to 4 groups and intraperitoneally injected with AlCl3 solution at 0, 5, 10, 20 mg/(kg·d), respectively, for weeks. The kidney function contents measured, pathological structural changes apoptosis observed. Meanwhile, expression fibrosis- apoptosis-related proteins was detected western blot. For...
Two new guaiane-type sesquiterpenes, kwangsiensis A and B (1-2) were isolated from the roots of Curcuma kwangsiensis. Their structures elucidated by extensive spectroscopic methods, including NMR, circular dichroism (CD) high-resolution mass-spectrometry. The anti-inflammatory activity two compounds was evaluated on basis their inhibition lipopolysaccharide (LPS)-induced nitric oxide (NO) production in mouse RAW 264.7 macrophages. Compounds 1 2 showed moderate inhibitory activities with IC50...
Dolichomitriopsis diversiformis is an endemic and threatened moss in eastern Asia. In vitro culture light microscopic observation were employed to study its developmental process from spore germination the formation of young gametophyte, as well effects temperature on protonemal development. Microscopic observations revealed that spores positively photoblastic with exosporous germination, sporelings classified bryum-type. Light dark conditions compared understand their germination. 24 h...
Introduction The purpose of this study was to investigate long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3) effects in vitamin D (Vit. D) treatment endothelial cell damage induced by diabetes. Material and methods We used human umbilical vein cells (HUVECs) as a research objective our high glucose diabetic model. evaluated apoptosis flow cytometry, inflammatory factors (IL-6, IL-1β TNF-α) concentrations ELISA assay, relative protein expression RT-qPCR WB NF-κB(p65) nuclear...