A5081920875- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Cancer Mechanisms and Therapy
- Cytokine Signaling Pathways and Interactions
- CAR-T cell therapy research
- Cancer Research and Treatments
- Advanced biosensing and bioanalysis techniques
- Lung Cancer Treatments and Mutations
- RNA Interference and Gene Delivery
- Liver Disease Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Autophagy in Disease and Therapy
- Viral Infections and Outbreaks Research
- Pharmaceutical studies and practices
- IL-33, ST2, and ILC Pathways
- Advanced Glycation End Products research
- Lung Cancer Research Studies
- Melanoma and MAPK Pathways
- DNA and Biological Computing
- MicroRNA in disease regulation
- Ion channel regulation and function
- Chronic Lymphocytic Leukemia Research
- CRISPR and Genetic Engineering
- Modular Robots and Swarm Intelligence
- Gastric Cancer Management and Outcomes
The University of Texas MD Anderson Cancer Center
2023-2025
Wuhan Institute of Virology
2014-2024
Chinese Academy of Sciences
2003-2024
Huazhong University of Science and Technology
2013-2024
Tongji Hospital
2013-2024
Renji Hospital
2024
Southern Illinois University School of Medicine
2024
Suizhou Central Hospital
2022-2024
Southwest Hospital
2024
Chifeng Municipal Hospital
2022-2024
Chimeric antigen receptor (CAR) therapy is a promising immunotherapeutic strategy for treating multiple refractory blood cancers, but further advances are required solid tumor CAR therapy. One challenge identifying safe and effective antigen. Here, we devise targeting hepatocellular carcinoma (HCC, one of the deadliest malignancies). We report that T NK cells transduced with recognizes surface marker, CD147, also known as Basigin, can effectively kill various malignant HCC cell lines in...
Patients with advanced non-small cell lung cancer (NSCLC) harboring activating EGFR mutations are initially responsive to tyrosine kinase inhibitors (TKI). However, therapeutic resistance eventually emerges, often via secondary or EGFR-independent mechanisms such as epithelial-to-mesenchymal transition. Treatment options after EGFR-TKI limited anti-PD-1/PD-L1 typically display minimal benefit. Given that IL6 is associated worse outcomes in patients NSCLC, we investigate whether part...
Aberrant expression of microRNAs in different human cancer types has been widely reported. MiR-218 acts as a tumor suppressor diverse impacting regulation multiple genes oncogenic pathways. Here, we evaluated the and function miR-218 lung ALDH positive cells to understand potential mechanisms responsible for disease pathology. Also, association between its host target could be useful towards better understanding prognosis clinical settings. Publicly-available data from The Cancer Genome...
Clinical success of chimeric antigen receptor (CAR) T cell immunotherapy requires the engineering autologous cells, which limits broader implementation CAR therapy. The development allogeneic and universal products will significantly broaden their application reduce costs. Allogeneic natural killer (NK) cells can be used for immunotherapy. Here, we develop an alternative approach rapid expansion primary NK CAR-NK with superior capability in vivo cytotoxicity from various sources (including...
Autophagy deficiency in macrophages exacerbates inflammation atherosclerosis (AS), and recently, galectin-3 (Gal-3) has been implicated as a critical promoter of AS. Further, melatonin (Mel) exerts an autophagy-promoting effect many chronic inflammatory diseases. In this study, we aimed to investigate whether Mel inhibits AS progression by downregulating Gal-3 enhance autophagy inhibit inflammation. Thus, performed vivo vitro experiments using high-fat diet (HFD)-fed ApoE-/- mice THP-1...
Objective 1,25(OH) 2 D 3 has been reported to attenuate liver steatosis; however, its exact mechanism of action remains poorly understood. This study aimed determine whether can hepatic steatosis by inducing autophagy. Methods Male C57BL/6 mice fed a high‐fat diet (HFD) were injected with for 4 weeks. These given 3‐methyladenine (3‐MA) inhibit HepG2 cells preincubated free fatty acid (FFA) and then treated . Vitamin receptor (VDR) shRNA autophagy‐related 16‐like 1 (ATG16L1) siRNA used VDR...
We previously demonstrated that baicalein could protect against liver ischemia/reperfusion (I/R) injury in mice. The exact mechanism of remains poorly understood. Autophagy plays an important role protecting I/R injury. This study was designed to determine whether via induction autophagy rats. Baicalein intraperitoneally injected 1 h before warm ischemia. Pretreatment with prior insult significantly blunted I/R-induced elevations serum aminotransferase levels and improved the histological...
Enhancing the CO2 mass transfer and proton supply in photocatalytic reduction of with H2O into CH3OH (PRC-M), while avoiding hydrogen evolution reaction (HER), remains a challenge. Herein, we propose an approach to control surface coverage by modifying interfacial wettability, which is achieved modulating core-shell structure expose either hydrophobic melamine-resorcinol-formaldehyde (MRF) or hydrophilic NiAl-layered double hydroxides (NAL). Characterizations reveal that insufficient leads...
Abstract Perylene diimides (PDIs) have garnered considerable attention due to their immense potential in photocatalysis. However, manipulating the molecular packing within aggregates and enhancing efficiency of photogenerated carrier recombination remain significant challenges. In this study, we demonstrate incorporation a PDI unit into covalent organic framework (COF), named PDI‐PDA, by linking an ortho‐substituted with p ‐phenylenediamine (PDA) control its intermolecular aggregation. The...
Summary Recent studies showing the therapeutic effect of young blood on aging‐associated deterioration organs point to as solution for clinical problems related old age. Given that defective autophagy has been implicated in aging and organ injuries, this study was designed determine aging‐induced alterations hepatic function underlying mechanisms, with a focus autophagy. Aged rats (22 months) were treated pooled plasma (1 ml, intravenously) collected from (3 or aged three times per week 4...
The advent of next generation sequencing (NGS) technologies has expedited the discovery novel genetic lesions in DLBCL. prognostic significance these identified gene mutations is largely unknown. In this study, we performed NGS for 27 genes most frequently implicated 196 patients. Interestingly, TP53 were found to be significantly more common DLBCL with MYC translocations (r = 0.446, P 0.034). While no mutation was prevalent patients bone marrow involvement, MYD88 primary CNS or testis. To...
Betulinic acid (BA), as a prospective natural compound, shows outstanding antitumor bioactivities against many solid malignancies. However, its mechanism multiple myeloma (MM) remains elusive. Herein, for the first time, we studied activity of BA MM both in vivo and vitro. We showed that mediated cytotoxicity cells through apoptosis, S-phase arrest, mitochondrial membrane potential (MMP) collapse, overwhelming reactive oxygen species (ROS) accumulation. Moreover, when ROS scavenger N-acetyl...
OBJECTIVE Recent genome-wide association studies (GWAS) revealed that a 9p21.3 locus was associated with type 2 diabetes. In this study, we carried out large-scale case-control study in the GeneID Chinese Han population to 1) further replicate of diabetes GWAS single nucleotide polymorphisms (SNPs) and 2) assess these SNPs coronary artery disease. RESEARCH DESIGN AND METHODS Three (rs2383208, rs10811661, rs10757283) were genotyped two cohorts 3,167 individuals. Case-control design used...
Chronic rejection that leads to diffuse narrowing and occlusion of graft vessels is the most important cause morbidity mortality following cardiac transplantation. The role underlying mechanism high-mobility group box 1 (HMGB1), as an established inflammatory mediator in acute rejection, remains poorly understood chronic rejection. Here, we assessed effects mechanisms HMGB1 on using single MHC Class II-mismatched mouse transplantation model. It was found increased accompanying with...