A5054280511- Renal cell carcinoma treatment
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Renal and related cancers
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Aluminum Alloy Microstructure Properties
- Cancer Immunotherapy and Biomarkers
- Aluminum Alloys Composites Properties
- ATP Synthase and ATPases Research
- Prostate Cancer Diagnosis and Treatment
- Circular RNAs in diseases
- Machine Learning in Bioinformatics
- Advanced ceramic materials synthesis
- HER2/EGFR in Cancer Research
- Ubiquitin and proteasome pathways
- Ultrasonics and Acoustic Wave Propagation
- interferon and immune responses
- Structural Health Monitoring Techniques
- Cancer-related Molecular Pathways
- Cancer Treatment and Pharmacology
- Lung Cancer Diagnosis and Treatment
- Biochemical and Structural Characterization
Affiliated Hospital of Nantong University
2025
Nantong University
2025
China Three Gorges University
2025
Soochow University
2023-2024
Third Affiliated Hospital of Sun Yat-sen University
2023
Sun Yat-sen University
2023
Anhui Provincial Hospital
2022
Shandong University
2006-2014
Harvard University
1995
Merck & Co., Inc., Rahway, NJ, USA (United States)
1992
Advanced glycosylation end products of proteins (AGEs) are nonenzymatically glycosylated which accumulate in vascular tissue aging and at an accelerated rate diabetes. A approximately 35-kDa polypeptide with a unique NH2-terminal sequence has been isolated from bovine lung found to be present on the surface endothelial cells where it mediates binding AGEs (receptor for advanced product or RAGE). Using oligonucleotide probe based amino-terminal RAGE, apparently full-length cDNA 1.5 kilobases...
Clear cell renal carcinoma (ccRCC) is the most common subtype of lethal kidney cancer. Reprogramming fatty acid and glucose metabolism resulting in accumulation lipids glycogen cytoplasm a hallmark ccRCC. Here, we identified micropeptide ACLY-BP encoded by GATA3-suppressed LINC00887, which regulated lipid promoted proliferation tumor growth Mechanistically, stabilizes ATP citrate lyase (ACLY) maintaining ACLY acetylation preventing from ubiquitylation degradation, thereby leading to...
ABSTRACT Background Prior studies have concentrated exclusively on how different prostate‐specific antigen (PSA) levels affect the prognosis of high‐grade prostate cancer (PCa), often overlooking low‐grade PCa. Methods The present cohort study included individuals diagnosed with PCa from Surveillance, Epidemiology, and End Results (SEER) database between 2010 2021. all‐cause mortality (ACM) cancer‐specific (PCSM) for each treatment group was calculated stratified by four PSA (≤ 4.0,...
Long non-coding RNAs (lncRNAs) are a type of RNA with length more than 200 nucleotides. They do not encode proteins but crucial in regulating gene expression and affecting the malignant biological behavior cancer. Small nucleolar host 10 (SNHG10) is novel lncRNA that plays regulatory role many tumors. Several recent studies have shown SNHG10 aberrantly expressed various forms This instability closely related to important tumorigenic processes, such as cell proliferation, migration, invasion,...
Rab5 is a Ras-related GTP-binding protein that post-translationally modified by prenylation. We report here an N-terminal domain contained within the first 22 amino acids of critical for efficient geranylgeranylation protein's C-terminal cysteines. This immediately upstream from "phosphate binding loop" common to all proteins and contains highly conserved sequence recognized among members Rab family, referred as YXYLFK motif. A truncation mutant lacks this (Rab5(23-215) fails become...
<title>Abstract</title> Deactivation of immune cells is a major characteristic in various malignant tumors, including breast cancer, complex and cancer. Here, using single-cell RNA sequencing, we identified UGDH-AS1+ NK specific to the triple-negative cancer(TNBC) subtype, which encode micropeptide NKSM promoting cancer progression by inhibiting cell activity. was upregulated associated with TNBC-infiltrating (TINK) antitumor Conditional knock-in into mice resulted deactivation increased...
<p>Related information to figure 2, 3, and 5</p>
<p>Related to Figure 2</p>
<p>Screening of candidate lncRNAs and biologic characterization LINC00887</p>
<p>Related information to figure 6</p>
<p>Supplementary Materials and Methods</p>