A5114685702- Cancer-related molecular mechanisms research
- Animal Nutrition and Physiology
- RNA modifications and cancer
- Animal Genetics and Reproduction
- Aquaculture Nutrition and Growth
- Muscle metabolism and nutrition
- Cancer-related gene regulation
- Circular RNAs in diseases
- Circadian rhythm and melatonin
- Neonatal Respiratory Health Research
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Rabbits: Nutrition, Reproduction, Health
- Heart Rate Variability and Autonomic Control
- Meat and Animal Product Quality
- Physiological and biochemical adaptations
- Silk-based biomaterials and applications
- Endoplasmic Reticulum Stress and Disease
- Reproductive biology and impacts on aquatic species
- Light effects on plants
- T-cell and B-cell Immunology
- Kruppel-like factors research
- Silkworms and Sericulture Research
- Muscle Physiology and Disorders
- TGF-β signaling in diseases
Jiangsu Academy of Agricultural Sciences
2021-2025
Animal Science Research Institute
2025
Soochow University
2019-2024
Ministry of Agriculture
2024
Ministry of Science and Technology
2024
Ministry of Agriculture and Rural Affairs
2021-2024
Henan University of Science and Technology
2023
First Affiliated Hospital of Jiangxi Medical College
2022
Weatherford College
2021
Committee on Publication Ethics
2021
Triple-negative breast cancer (TNBC) is a subtype of (BC) with the most aggressive phenotype and poor overall survival. Using bioinformatics tools, we identified LINC00908 encoding 60–aa polypeptide differentially expressed in TNBC tissues. We named this endogenously ASRPS (a small regulatory peptide STAT3). expression was down-regulated TNBCs associated showed that directly regulated by ERα, which responsible for differential down-regulation TNBCs. bound to STAT3 through coiled coil domain...
Though esophageal cancer is three to four times more common among males than females worldwide, this type of still ranks in the top incidence women, even female specific types. The occurrence currently attributed extrinsic factors, including tobacco use and alcohol consumption. However, limited attention has been given gender-specific intrinsic genetic especially female. We re-annotated a large cohort microarrays on 179 ESCC patients identified female-specific differently expressed lncRNAs....
The objective of this study was to investigate the effects sex on meat quality and composition amino fatty acids in breast muscles White King pigeon squabs. Untargeted metabolomics also conducted distinguish metabolic plasma different sexes. Compared with male squabs, female squabs had greater intramuscular fat (IMF) deposition lower myofiber diameter hydroxyproline content, leading a shear force. Female higher monounsaturated acid n-6 n-3 polyunsaturated proportions muscle, lipogenesis...
Reproduction in avian species is regulated by light, and the hypothalamus most important regulator of response to light signals. The objective this study was identify key molecules signaling pathways that regulate reproduction birds based on photoperiod. Yangzhou geese kept a closed goose barn were selected for transcriptome sequencing. program during rearing as follows: short photoperiod (light[L]: dark[D]=6.5 h:17.5 h) 60 days, followed prolonged (L:D = 11.5 h:12.5 h). Samples collected...
Endoplasmic reticulum stress (ER stress) is a double-edged sword in the occurrence and development of malignant cancer. The aim this study was to explore roles ER metastasis epithelial-mesenchymal transitionin triple-negative breast cancer (TNBC) potential mechanisms. In study, 4-PBA administrated inhibit stress. Cell viability evaluated using cell counting kit-8 assay. migration invasion were identified by wound healing transwell assay, respectively. Levels MMP2 MMP9 measured enzyme-linked...
ChgA has recently been identified as the autoantigen for diabetogenic CD4+ T cells in NOD mice and T1D patients. However, autoreactive CD8+ T-cell responses targeting haven't studied yet. Here several HLA-A*0201-restricted peptides derived from mChgA hChgA were selected by an integrated computational prediction approach, followed HLA-A*0201 binding assay. MChgA10–19 mChgA43–52 peptides, which bound well with molecule, induced significant proliferation IFN-γ-releasing of splenocytes diabetic...
Egg turning during incubation plays important roles in achieving high hatching performance and gosling quality. The objective of this study was to improve embryonic muscular developments so achieve better quality by wider egg angles incubation, unravel the associated regulatory molecular mechanisms. In each three consecutive incubations, 1,728 goose eggs were divided into 3 groups that set same type commercial incubators with adjusted differently 50°, 60°, 70°, respectively. On average...
LncRNAs (long noncoding RNAs) are transcripts that more than 200 nt long and have been described as the largest subclass in transcriptome humans. Although studies of lncRNAs cancer continuing for a time, no much has known about X chromosome‐linked lncRNAs. Here, by using RNA‐seq we report identification new lncRNA ( lnc‐XLEC1 ) is aberrantly downregulated during development endometrial carcinoma (EC). The overexpression reduces migration proliferation EC cells. Flow cytometry analysis...
We aimed to investigate how wide-angle turning of eggs during incubation affected yolk utilization and the associated molecular mechanism, along with improved goose embryonic development. In total, 1152 (mean weight: 143.33 ± 5.43 g) were divided equally incubated in two commercial incubators tray angles adjusted differently, either 50° or 70°. Following under standard temperature humidity level, by 70° increased days 22 (E22), embryo mass, gosling weight at hatching, egg hatchability, but...
Ovarian angiogenesis is an extremely rapid process that occurs during the transition from follicle to corpus luteum (CL) and crucial for reproduction. It regulated by numerous factors including transforming growth factor-β1 (TGFB1). However, regulatory mechanism of TGFB1 in ovarian not fully understood. To address this, this study we obtained high-throughput transcriptome analysis (RNA-seq) data bovine luteinizing follicular cells cultured a system mimicking treated with TGFB1, identified...
Abstract Background: Coronary heart disease is a serious cardiovascular disease. There coronary atherosclerosis, resulting in lumen stenosis, blockage, and then the symptoms of insufficient blood supply hypoxia myocardium. Chronic failure kind syndrome with abnormal ventricular filling ejection function, which final stage development At present, treatment plan Western medicine can significantly reduce hospitalization rate, but it still not satisfactory for prognosis mortality patients....
The influence of monochromatic green light stimulation on hatching performance and embryo development has been studied in chickens, but not geese. liver crucial functions the regulation energy metabolism during embryogenesis, its involvement transduction is still unidentified. We aimed to determine Yangzhou goose development. also investigated metabolomics transcriptomic responses embryonic underlying molecular mechanisms. Eggs were incubated under either 12 h light/dark (12 L:12D) cycles or...
The photoperiod is an important factor during rearing and laying period that affects age body weight at sexual maturation reproductive performance in poultry; however relevant research on this pigeons still lacking. Thus, study investigated the effects of different photoperiodic programs hormonal profile White King pigeons. From 101 d age, control group were exposed to a natural until 160 d, then 16 h (16 light (L): 8 dark (D)) lasted for 200 days. Pigeons three experimental groups short 8L:...
Egg turning in incubation is crucial to the development of embryos and hatching performance. We aimed develop a high performance duck egg technique by enlarging changing angles. Increasing angle from 45 75° did not affect embryo early mortality during first 15 d incubation, which ranged 3.5 4.0%, but accelerated chorioallantoic membrane (CAM) 17 h, significantly (P < 0.01) reduced late 9.4 ± 0.98% 5.31 0.63%. As result, fertile hatchability increased 91.03 0.97% 94.64 0.61% 0.05), so was...
The light provide during incubation can influence hatching characteristics (hatching time, hatchability, etc.) and embryo development in chickens, geese, turkeys. However, relevant studies on this factor pigeons are lacking. This study investigated the effects of ovo photostimulation embryogenesis performance, squab quality, pigeons. 400 eggs from paired- bred were randomly distributed into 4 lighting treatments, with 2 replicates per treatment. treatments included dark as a control (NL),...
<title>Abstract</title> Deactivation of immune cells is a major characteristic in various malignant tumors, including breast cancer, complex and cancer. Here, using single-cell RNA sequencing, we identified UGDH-AS1+ NK specific to the triple-negative cancer(TNBC) subtype, which encode micropeptide NKSM promoting cancer progression by inhibiting cell activity. was upregulated associated with TNBC-infiltrating (TINK) antitumor Conditional knock-in into mice resulted deactivation increased...