A5111755773- RNA modifications and cancer
- Crop Yield and Soil Fertility
- Cancer, Hypoxia, and Metabolism
- Neural dynamics and brain function
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Functional Brain Connectivity Studies
- MicroRNA in disease regulation
- Environmental and Agricultural Sciences
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Irrigation Practices and Water Management
- Plant nutrient uptake and metabolism
- Mitochondrial Function and Pathology
- Rice Cultivation and Yield Improvement
- Endoplasmic Reticulum Stress and Disease
- Advanced Neuroimaging Techniques and Applications
- RNA Research and Splicing
- Plant responses to water stress
- interferon and immune responses
- Selenium in Biological Systems
- Neuroscience and Neuropharmacology Research
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Cancer Research and Treatments
Ministry of Civil Affairs
2019-2025
Xi'an Jiaotong University
2016-2025
Henan University of Science and Technology
2011-2025
Case Western Reserve University
2017-2025
Shanghai Customs College
2024
Jilin University
2014-2023
Haikou City People's Hospital
2023
Northeast Petroleum University
2006-2023
NARI Group (China)
2019-2023
East China Jiaotong University
2023
Summary Selenite is a predominant form of selenium (Se) available to plants, especially in anaerobic soils, but the molecular mechanism selenite uptake by plants not well understood. ltn1 , rice mutant previously shown have increased phosphate (Pi) uptake, was found exhibit higher than wild‐type both concentration‐ and time‐dependent assays. Respiratory inhibitors significantly inhibited wildtype mutant, indicating that coupled with H + energy‐dependent. greatly enhanced under Pi‐starvation...
The comparative typing of matched tumor and blood DNAs at dinucleotide repeat (microsatellite) loci has revealed in DNA the presence alleles that are not observed normal DNA. occurrence these additional is possibly due to replication errors (RERs). Although this observation led recognition a subtype colorectal cancer with high incidence RERs (caused by deficiency mismatch repair), thorough analysis RER frequency consecutive series cancers had been reported. It shown here extensive 88 tumors...
Microsatellite instability (MI) characterizing tumors with replication errors (RER+ tumors) was first described in colorectal from hereditary non-polyposis cancer (HNPCC) patients as well sporadic cases. It has also been observed subgroups of extracolonic tumors, but there is no consensus to the number microsatellite loci examine, and threshold percentage unstable required classify a tumor RER+. We have recently shown that BAT-26, mononucleotide repeat microsatellite, quasi-monomorphic DNA...
The tumor suppressor Merlin/NF2 functions upstream of the core Hippo pathway kinases Lats1/2 and Mst1/2, as well nuclear E3 ubiquitin ligase CRL4DCAF1. Numerous mutations Merlin have been identified in Neurofibromatosis type 2 other cancer patients. Despite more than two decades research, regulator remains unknown. Here we show by high-resolution crystal structures that Lats1/2-binding site on FERM domain is physically blocked Merlin's auto-inhibitory tail. Angiomotin binding releases...
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death that develops as consequence obesity, cirrhosis, and chronic hepatitis. However, the pathways along which these changes occur remain incompletely understood.In this study, we show deubiquitinase USP30 abundant in HCCs arise mice maintained on high-fat diets. IKKβ phosphorylated stabilized USP30, promoted to deubiquitinate ATP citrate lyase (ACLY) fatty acid synthase (FASN). also directly ACLY facilitated interaction...
Selenium (Se) is an essential trace element for humans and other animals, yet approximately one billion people worldwide suffer from Se deficiency. Rice a staple food over half of the world's population that major dietary source Se. In paddy soils, rice roots mainly take up selenite. speciation analysis indicated most selenite absorbed by predominantly transformed into selenomethinone (SeMet) retained in roots. However, mechanism which SeMet transported plants remains largely unknown. this...
Background and Aims: Cholesterol ester (CE) biosynthesis homeostasis play critical roles in many cancers, including HCC, but their exact mechanistic contributions to HCC disease development require further study. Approach Results: Here, we report on a proposed role of tumor suppressor P53 its repressing ubiquitin‐specific peptidase 19 (USP19) sterol O‐acyltransferase (SOAT) 1, which maintains CE homeostasis. USP19 enhances cholesterol esterification contributes hepatocarcinogenesis (HCG) by...
The tillage method and straw returning are the two most important agronomic measures for crop production, but their combined effects on nutrient accumulation utilization grain yield in dryland winter wheat (Triticum aestivum L., namely wheat)–summer maize (Zea mays maize) double-cropping system still poorly understood. present study delves into impact of wheat–maize based a field split-plot positioning experiment (started October 2009). Three methods—plowing (PT, 30–35 cm depth), rotary (RT,...
Abstract c-Myc (Myc) plays an important role in normal liver development and tumorigenesis. We show here that Myc is pathologically activated essential for promoting human hepatocellular carcinoma (HCC). induces HCC through a novel, microRNA (miRNA)-mediated feedback loop comprised of miR-148a-5p, miR-363-3p, ubiquitin-specific protease 28 (USP28). directly binds to conserved regions the promoters two miRNAs represses their expression. miR-148a-5p targets inhibits Myc, whereas miR-363-3p...
Significance The Crumbs–PALS1–PATJ complex is vital for the development and maintenance of polarity diverse tissues. Defects in formation are known to cause diseases such as cancer blindness. highly conserved cytoplasmic tail transmembrane protein Crumbs responsible apical targeting complex. However, molecular basis governing specific Crumbs–PALS1 poorly understood. We discovered that PDZ–SH3–GK tandem PALS1 forms a structural supramodule interacting with large part high affinity...
Abstract STAT3 is a transcription factor that plays central roles in various physiological processes and its deregulation results serious diseases including cancer. The mechanisms on how activity regulated remains enigmatic. Here we identify TRIM27 as positive regulator of II-6-induced activation downstream gene expression. localizes to retromer-positive punctate structures serves critical link for recruiting gp130, JAK1, subsequent phosphorylation at the structures. Overexpression promotes...
Deubiquitinases (DUBs) play essential roles in normal cell proliferation and tumor growth. However, the molecular mechanisms of DUBs on hepatocellular carcinoma (HCC) remains largely unknown. In this study, based analysis several HCC datasets, we found that USP21 gene, which encodes a member ubiquitin-specific protease family, is highly amplified overexpressed HCCs, with extent up-regulation significantly correlating poor clinical outcomes. Inhibition lines decreased proliferation,...
Resting-state fMRI studies have demonstrated that Alzheimer's disease (AD) is associated with aberrant organization and function of large-scale brain networks. However, the nature disruption cross-network interactions in key neurocognitive networks remains unclear. In thi s paper, we examined 'triple-network model', including default mode network (DMN), salience (SN), central executive (CEN), to identify late mild cognitive impairment (LMCI) AD. With resting-state fMRI, tested functional...
Erythropoietin (Epo) is a major regulator of erythropoiesis that alters the survival, proliferation, and differentiation erythroid progenitor cells. The mechanism by which these events are regulated has not yet been determined. Using HB60, newly established erythroblastic cell line, we show here Epo-induced terminal associated with transient downregulation in expression Ets-related transcription factor Fli-1. Constitutive Fli-1 HB60 cells, similar to retroviral insertional activation...
Abstract miRNAs are involved in many physiologic and disease processes by virtue of degrading specific mRNAs or inhibiting their translation. miR-148a has been implicated the control tumor growth cholesterol triglyceride homeostasis using vitro vivo gene expression- silencing-based approaches. Here knockout (KO) mice were used to investigate intrinsic role liver physiology hepatocarcinogenesis mice. downregulation was found be correlated with poor clinical outcomes hepatocellular carcinoma...