A5089497452- Air Quality and Health Impacts
- Air Quality Monitoring and Forecasting
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Atmospheric chemistry and aerosols
- Microtubule and mitosis dynamics
- RNA Research and Splicing
- Genomic variations and chromosomal abnormalities
- Anomaly Detection Techniques and Applications
- Climate Change and Health Impacts
- Urban Heat Island Mitigation
- Recommender Systems and Techniques
- Network Security and Intrusion Detection
- Genetic and Kidney Cyst Diseases
- Advanced Graph Neural Networks
- Cellular Mechanics and Interactions
- Protist diversity and phylogeny
- Domain Adaptation and Few-Shot Learning
- Micro and Nano Robotics
- Circular RNAs in diseases
- Impact of Light on Environment and Health
- Vehicle emissions and performance
- Advanced Computational Techniques and Applications
- Advanced Neural Network Applications
- Remote Sensing and LiDAR Applications
Gansu Agricultural University
2024
Tsinghua University
2007-2024
University Town of Shenzhen
2024
Wuhan University
2023
China Medical University
2017-2023
Tsinghua–Berkeley Shenzhen Institute
2023
Alibaba Group (China)
2022
Yale University
2016-2020
Henan University
2020
Kunming Medical University
2019
The GENCODE project has collected over 10,000 human long non-coding RNA (lncRNA) genes. However, the vast majority of them remain to be functionally characterized. Computational investigation potential functions lncRNA genes is helpful guide further experimental studies on lncRNAs. In this study, based expression correlation between lncRNAs and protein-coding across 19 normal tissues, we used hypergeometric test annotate a single or set with significantly enriched functional terms among that...
Long non-coding RNAs (lncRNAs) have emerged as critical regulators of genes at epigenetic, transcriptional and post-transcriptional levels, yet what are regulated by a specific lncRNA remains to be characterized. To assess the effects on gene expression, an increasing number researchers profiled genome-wide or individual expression level change after knocking down overexpressing lncRNA. Herein, we describe curated database named LncRNA2Target, which stores lncRNA-to-target is publicly...
The eukaryotic flagellum beats periodically, driven by the oscillatory dynamics of molecular motors, to propel cells and pump fluids. Small but perceivable fluctuations in beat individual flagella have physiological implications for synchronization collections as well hydrodynamic interactions between flagellated swimmers. Here, we characterize phase amplitude flagellar bending waves using shape mode analysis limit-cycle reconstruction. We report a quality factor oscillations...
This study estimates adult mortalities attributed to PM2.5 across urban China in 2015 and the corresponding that might be avoided by meeting yearly averaged indoor threshold newly established Assessment Standard for Healthy Building (ASHB) seven other potential thresholds. We use outdoor concentrations from ∼1500 monitoring sites 339 Chinese cities, coupled with a detailed exposure model, estimate exposures originating outdoors. proceed calculate premature mortality attributable using an...
Abstract Radial spokes (RS) transmit mechanochemical signals between the central pair (CP) and axonemal dynein arms to coordinate ciliary motility. Atomic-resolution structures of metazoan RS complexes in ependymal cilia, whose rhythmic beating drives circulation cerebrospinal fluid, however, remain obscure. Here, we present near-atomic resolution cryo-EM mouse head-neck complex both monomer dimer forms reveal intrinsic flexibility dimer. We also map genetic mutations related primary...
Abstract Vesicles of lipid bilayer can adopt a variety shapes due to different coating proteins. The ability proteins reshape membrane is typically characterized by inducing spontaneous curvature the at coated area. BAR family are known have crescent shape and induce along its concaved body axis but not in perpendicular direction. We model this type as rod-shaped molecule with an orientation normal tangential plane surface. show how ring these axisymmetric vesicle when protein or varied. A...
Positioning of microtubule (MT) organizing centers with respect to the confining geometry cells depends on pushing and/or pulling forces generated by MTs that interact cell cortex (Dogterom et al 2005 Curr. Opin. Cell Biol. 17 67–74). How, in living cells, these lead proper positioning is still largely an open question. Recently, it was shown vitro experiments using artificial microchambers a square geometry, MT asters center more reliably combination and than alone (Laan 2012a 148 502–14)....
High-throughput genomic technologies like lncRNA microarray and RNA-Seq often generate a set of lncRNAs interest, yet little is known about the transcriptional regulation genes. Here, based on ChIP-Seq peak lists transcription factors (TFs) from ENCODE annotated human GENCODE, we developed web-based interface titled “TF2lncRNA,” where TF peaks each experiment are crossed with coordinates input lncRNAs, to identify which TFs present statistically significant number binding sites (peaks)...
While PM2.5 (particles with aerodynamic diameter less than 2.5 µm) concentrations in China are beginning to decline because of pollution abatement measures, ozone (O3) continue rise. In this study, we have used a Monte Carlo approach estimate breathing-rate adjusted (BRA) population exposure and its oxidation products based on hourly O3 measurements collected 2017 from monitoring stations 333 Chinese cities. The median measured outdoor concentration these cities was 31 ppb, while the...
In cells, dynamic microtubules organize into asters or spindles to assist positioning of organelles. Two types forces are suggested contribute the process: (i) microtubule-growth based pushing forces; and (ii) motor protein mediated pulling forces. this paper, we present a general theory account for aster in confinement arbitrary shape. The takes microtubule nucleation, growth, catastrophe, slipping, as well interaction with cortical force generators. We calculate distributions acting on...
Increasing studies have revealed that long noncoding RNAs (lncRNAs) are not transcriptional noise but play important roles in the regulation of a wide range biological processes, and dysregulation lncRNA genes is associated with disease development. Alzheimer’s (AD) chronic neurodegenerative usually starts slowly gets worse over time. However, little known about AD how transcriptionally regulated. Herein, we analyzed RNA-seq data ChIP-seq histone modification from CK-p25 model control mice...
Augment the training data has a significant effect for deep learning on small-scale dataset. For practical semantic segmentation applications, it is hard work to collect and annotate enough neural network. In this paper, we focus which augmentation (DA) method better, what combination of different DA methods can improve network performance more. Our target application highland AI-Ranch many data. We firstly produce open source sheep dataset including hundreds images, referred as SSG Seven...
Air pollution monitoring is a concerned issue in urban management. Nowadays, vehicle-based mobile sensing systems are deployed to enhance granularity. However, these systems, the number of online sensors may change over time and long-term maintenance costly. Therefore, an inference algorithm necessary maintain high spatiotemporal granularity field under both dense sparse sampling. In this paper, we propose based on super-resolution scheme. To address challenges complex external factors...
LncRNAs (long noncoding RNAs) are transcripts that more than 200 nt long and have been described as the largest subclass in transcriptome humans. Although studies of lncRNAs cancer continuing for a time, no much has known about X chromosome‐linked lncRNAs. Here, by using RNA‐seq we report identification new lncRNA ( lnc‐XLEC1 ) is aberrantly downregulated during development endometrial carcinoma (EC). The overexpression reduces migration proliferation EC cells. Flow cytometry analysis...
Air pollution is a global health threat. Except static official air quality stations, mobile sensing systems are deployed for urban monitoring to achieve larger coverage and greater sampling granularity. However, the data sparsity irregularity also bring great challenges map recovery. To address these problems, we propose deep autoencoder framework based inference algorithm. Under framework, partially observed formed by irregular samples input into model, then an encoder decoder work...