A5054769508- Effects and risks of endocrine disrupting chemicals
- Air Quality and Health Impacts
- Toxic Organic Pollutants Impact
- Microplastics and Plastic Pollution
- Dementia and Cognitive Impairment Research
- Pluripotent Stem Cells Research
- Per- and polyfluoroalkyl substances research
- Carcinogens and Genotoxicity Assessment
- RNA modifications and cancer
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Recycling and Waste Management Techniques
- Birth, Development, and Health
- Cancer-related molecular mechanisms research
- Energy and Environment Impacts
- Ferroelectric and Piezoelectric Materials
- Microwave Dielectric Ceramics Synthesis
- Air Quality Monitoring and Forecasting
- Acoustic Wave Resonator Technologies
- Health, Environment, Cognitive Aging
- Neurological Disease Mechanisms and Treatments
- Biomedical Ethics and Regulation
- Graphene and Nanomaterials Applications
- IL-33, ST2, and ILC Pathways
- MicroRNA in disease regulation
Shanghai Jiao Tong University
2016-2025
Shanghai Mental Health Center
2018-2025
Qilu Hospital of Shandong University
2024-2025
China Agricultural University
2025
Seventh People's Hospital of Dalian
2023-2024
Center for Life Sciences
2024
Nanjing University of Science and Technology
2024
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2024
Shanghai University of Traditional Chinese Medicine
2024
Shanghai Ninth People's Hospital
2017
Microplastics (MPs) are ubiquitous in the environment, including atmosphere. Yet, size detection limit measuring airborne MPs undermines determination of human MP exposure level through inhalation and also restricts understanding pollution behavior. To comprehensively accurately assess features air, we demonstrate a qualitative quantitively method using Raman microscopy to characterize suspended atmospheric MPs. Our methodology has achieved detailed characterization down 1 μm ensured all be...
Microplastic particles (MP) are prevalent in both industrial production and the natural environment, posing a significant concern for human health. Daily diet, air inhalation, skin contact major routines of MP intake human. The main injury target systems MPs include digestive system, respiratory cardiovascular system. However, study on MPs' adverse effects heart is less than other organs. Previous vivo studies have demonstrated that can induce injuries, including abnormal rate, apoptosis...
Abstract Fine particulate matter (PM 2.5 ) is a major component of air pollutions that are closely associated with increased risk lung cancer. However, the role PM in etiology cancer largely unknown. In this study, we performed acute (24 hours) and chronic (five passages) exposure models to investigate carcinogenetic mechanisms by targeting induction epithelial‐mesenchymal transition (EMT) stem cells (CSC) properties human non‐small cell line A549. We found both enhanced migration invasion,...
Abstract Per- and polyfluoroalkyl substances (PFAS) are widespread chemicals. Legacy PFAS have been phased out of production in most developed countries emerging (short-chain polyfluorinated compounds) used as legacy alternatives. The effect on cytokine homeostasis human remains poorly understood. This study aimed to evaluate the associations between profiles, identify main contributors disturbance homeostasis. We quantified 21 198 Chinese women childbearing age from 2015 2016. 13 cytokines...
Abstract Protein design is central to nearly all protein engineering problems, as it can enable the creation of proteins with new biological functions, such improving catalytic efficiency enzymes. One key facet design, fixed-backbone sequence seeks sequences that will conform a prescribed backbone structure. Nonetheless, existing methods present limitations, low diversity and shortcomings in experimental validation designed functional proteins. These inadequacies obstruct goal design. To...
Abstract Fine particulate matter (PM 2.5 ) has been implicated as a risk factor for neurodevelopmental disorders including autism in children. However, the underlying biological mechanism remains unclear. DNA methylation is suggested to be fundamental neuronal responses environmental cues. We prepared whole particle of PM ), water-soluble extracts (Pw), organic (Po) and carbon core component (Pc) characterized their chemical constitutes. found that induced significant redox imbalance,...
Thyroid nodules (TNs) are highly prevalent worldwide and have a pattern of female predominance. Bisphenol A (BPA) is an endocrine disruptor that can lead to adverse effects in human health. However, epidemiologic studies revealing the association between BPA exposure TNs limited results inconsistent. We aimed examine urinary women who more susceptible TNs.We conducted case-control study with 1416 aged 18 years or older (705 cases, 711 controls). All participants underwent thyroid...
Background: The Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) are the most commonly used tools for cognitive impairment screening. present study aimed to investigate ability of MOCA MMSE differentiate between cognitively normal elderly individuals, MCI patients dementia at different ages education levels establish optimal cutoff scores MoCA in Chinese elderly. Methods: A total 2,954 including 1,746 controls, 599 249 patients, were consecutively recruited...
Ageing is a nature process of microplastics that occurrs daily, and human beings are inevitably exposed to aged microplastics. However, systematic understanding ageing status its toxic effect currently still lacking. In this study, plastic cup lids-originated polypropylene (PP) were UV-photoaged until the carbonyl index (CI), canonical indicator for ageing, achieved 0.08, 0.17, 0.22 0.28. The adverse hepatic these PPs (aPPs) was evaluated in Balb/c mice (75 ng/mL water, about 200...
As the population in China rapidly ages, prevalence of mild cognitive impairment (MCI) is increasing considerably. However, causes MCI vary. The continued lack understanding various subtypes impedes implementation effective measures to reduce risk advancing more severe diseases. To estimate and incidence rates two subtypes-amnestic (aMCI) vascular without dementia (VCIND)-and determine modifiable factors for them among older individuals a multiregional Chinese cohort. This 1-year...
In this study, functional strains with strong fermentation characteristics were isolated from Strong-flavor Daqu and evaluated for their ability to enhance the quality antioxidant activity of Baijiu . Bacillus velezensis (S1), subtilis (S12), Escherichia coli (S16) identified as key strains. Fermentation experiments different inoculation amounts combinations revealed synergistic effects on activity. Specifically, total ester content in fermented 3% S1, S12 S16 increased by 5.68%, 53.41%...