A5100322884- Air Quality and Health Impacts
- Effects and risks of endocrine disrupting chemicals
- Per- and polyfluoroalkyl substances research
- Microplastics and Plastic Pollution
- Birth, Development, and Health
- Air Quality Monitoring and Forecasting
- Climate Change and Health Impacts
- Toxic Organic Pollutants Impact
- Energy and Environment Impacts
- Hemodynamic Monitoring and Therapy
- Health, Environment, Cognitive Aging
- Heavy metals in environment
- Graphene and Nanomaterials Applications
- Heavy Metal Exposure and Toxicity
- Biomarkers in Disease Mechanisms
- Ultrasound in Clinical Applications
- Adsorption and biosorption for pollutant removal
- Recycling and Waste Management Techniques
- Phosphorus and nutrient management
- Ion Transport and Channel Regulation
- Sphingolipid Metabolism and Signaling
- Redox biology and oxidative stress
- Atmospheric chemistry and aerosols
- Potassium and Related Disorders
- Acute Kidney Injury Research
Shanghai Jiao Tong University
2015-2024
Shanghai Ninth People's Hospital
2016-2024
XinHua Hospital
2013-2024
Hubei University of Medicine
2023
Shandong Center for Disease Control and Prevention
2023
Tongren Hospital
2015-2022
Shanghai First People's Hospital
2022
Xian Yang Central Hospital
2022
Shanghai Children's Medical Center
2020
Microplastics (MPs) are ubiquitous in the environment, including atmosphere. Yet, size detection limit measuring airborne MPs undermines determination of human MP exposure level through inhalation and also restricts understanding pollution behavior. To comprehensively accurately assess features air, we demonstrate a qualitative quantitively method using Raman microscopy to characterize suspended atmospheric MPs. Our methodology has achieved detailed characterization down 1 μm ensured all be...
Microplastic particles (MP) are prevalent in both industrial production and the natural environment, posing a significant concern for human health. Daily diet, air inhalation, skin contact major routines of MP intake human. The main injury target systems MPs include digestive system, respiratory cardiovascular system. However, study on MPs' adverse effects heart is less than other organs. Previous vivo studies have demonstrated that can induce injuries, including abnormal rate, apoptosis...
Abstract Fine particulate matter (PM 2.5 ) is a major component of air pollutions that are closely associated with increased risk lung cancer. However, the role PM in etiology cancer largely unknown. In this study, we performed acute (24 hours) and chronic (five passages) exposure models to investigate carcinogenetic mechanisms by targeting induction epithelial‐mesenchymal transition (EMT) stem cells (CSC) properties human non‐small cell line A549. We found both enhanced migration invasion,...
Abstract Fine particulate matter (PM 2.5 ) has been implicated as a risk factor for neurodevelopmental disorders including autism in children. However, the underlying biological mechanism remains unclear. DNA methylation is suggested to be fundamental neuronal responses environmental cues. We prepared whole particle of PM ), water-soluble extracts (Pw), organic (Po) and carbon core component (Pc) characterized their chemical constitutes. found that induced significant redox imbalance,...
Abstract Per- and polyfluoroalkyl substances (PFAS) are widespread chemicals. Legacy PFAS have been phased out of production in most developed countries emerging (short-chain polyfluorinated compounds) used as legacy alternatives. The effect on cytokine homeostasis human remains poorly understood. This study aimed to evaluate the associations between profiles, identify main contributors disturbance homeostasis. We quantified 21 198 Chinese women childbearing age from 2015 2016. 13 cytokines...
Ventilator‑associated lung injury (VALI) remains a significant medical problem in intensive care units. The present study aimed to investigate the role of sphingosine kinase 1 (SPHK1) VALI using two‑hit model and explore potential underlying molecular mechanism. Mice were divided into five groups: i) Non‑ventilated group; ii) non‑ventilated + lipopolysaccharide (LPS) iii) ventilated iv) LPS v) SPHK1 inhibitor group. administered (1 mg/kg) via an intraperitoneal injection. After 12 h, mice...
Thyroid hormone (TH), triiodothyronine (T3) and thyroxine (T4), which are released from the thyroid, control many cellular processes in various cell types. It is worth noting that TH plays a complex role skeletal metabolic balance, few studies have investigated whether exerts any effects on osteogenesis bone mesenchymal stem cells (MSCs). We explored of T3 morphogenetic protein 9 (BMP9)-induced osteogenesis, process considered most important osteogenic differentiation C3H10T1/2 cells. In...
Abstract Thrombocytopenia is independently related with increased mortality in severe septic patients. Renin‐angiotensin system (RAS) elevated subjects; accumulating studies show that angiotensin II (Ang II) stimulate the intrinsic apoptosis pathway by promoting reactive oxygen species (ROS) production. However, mechanisms underlying relationship of platelet and RAS sepsis have not been fully elucidated. The present study aimed to elucidate whether was involved pathogenesis sepsis‐associated...