A5058772771- Respiratory Support and Mechanisms
- Pain Mechanisms and Treatments
- Hydrogen's biological and therapeutic effects
- Sepsis Diagnosis and Treatment
- Stress Responses and Cortisol
- Pancreatitis Pathology and Treatment
- S100 Proteins and Annexins
- Immune cells in cancer
- Anesthesia and Neurotoxicity Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Biochemical effects in animals
- Cancer-related molecular mechanisms research
- Nanoplatforms for cancer theranostics
- Voice and Speech Disorders
- Advanced Nanomaterials in Catalysis
- Pneumocystis jirovecii pneumonia detection and treatment
- Gut microbiota and health
- Advanced Glycation End Products research
- Antibiotic Resistance in Bacteria
- Hemodynamic Monitoring and Therapy
- International Student and Expatriate Challenges
- Nerve injury and regeneration
- Antibiotics Pharmacokinetics and Efficacy
- Heme Oxygenase-1 and Carbon Monoxide
XinHua Hospital
2014-2025
Shanghai Jiao Tong University
2012-2025
Johns Hopkins University
2024-2025
Center for Excellence in Molecular Plant Sciences
2024
Chinese Academy of Sciences
2024
Zhejiang Normal University
2023
Fuzhou University
2023
Second Military Medical University
2008-2010
Changhai Hospital
2008-2010
Zhejiang University
2010
Hydrogen gas was reported to reduce reactive oxygen species and alleviate cerebral, myocardial hepatic ischemia/reperfusion (I/R) injuries. This paper studied the effect of hydrogen-rich saline, which easier for clinical application, on intestinal I/R injury. Model injury induced in male Sprague-Dawley rats. Physiological saline or nitrogen-rich (5 ml/kg) administered via intravenous infusion at 10 min before reperfusion, respectively. The intestine damage detected microscopically assessed...
Background The majority of the critically ill patients may have critical illness-related corticosteroid insufficiency (CIRCI). therapeutic effect dexamethasone be related to its ability improve cortical function. Recent study showed that can reduce COVID-19 deaths by up one third in patients. aim this article is investigate whether SARS-CoV-2 attack adrenal cortex aggravate relative insufficiency. Methods We summarized clinical features reported currently available observational studies....
Ventilator-induced lung injury (VILI) is caused by overdistension of the alveoli repetitive recruitment and derecruitment alveolar units. This study aims to investigate potential role mechanism fibroblast growth factor 21 (FGF21), a metabolic regulator secreted liver, in VILI development.Serum FGF21 concentrations were determined patients undergoing mechanical ventilation during general anesthesia mouse model. Lung was compared between FGF21-knockout (KO) mice wild-type (WT) mice....
Abstract Catalytic dynamic kinetic asymmetric transformation (DyKAT) provides a powerful tool to access chiral stereoisomers from racemic substrates. Such has been widely employed on the construction of central chirality, however, application in axial chirality remains underexplored because its equilibrium substrate enantiomers is limited five-membered metalacyclic intermediate. Here we report tetracoordinate boron-directed cross-coupling racemic, configurationally stable...
Mechanical ventilation can induce lung fibrosis. This study aimed to investigate whether ventilator-induced fibrosis was associated with endothelial-mesenchymal transition and uncover the underlying mechanisms.Randomized, controlled animal cell culture study.University research laboratory.Adult male Institute of Cancer Research, NACHT, LRR, PYD domains-containing protein 3 (NLRP3) knockout wild-type mice. Primary cultured mouse vascular endothelial cells.Institute NLRP3 mice were subjected...
P2X receptors on dorsal root ganglion (DRG) neurons have been strongly implicated in pathological nociception after peripheral nerve injuries or inflammation. However, nothing is known of a role for purinergic neuropathic pain produced by chronic compression DRG (CCD) - an injury that may accompany intraforaminal stenosis, laterally herniated disc other disorders the spine leading to radicular pain. In rat model compression, hyperexcitable retain functioning axonal connections with their...
Background: Salidroside (SDS) is the main effective ingredient of Rhodiola rosea L with a variety pharmacologic properties. We aim to investigate effects SDS on ventilation induced lung injury (VILI) and explore possible underlying molecular mechanism. Methods: Lung was in male ICR mice via mechanical (30 ml/kg) for 4h. The were divided four groups:(1) Control group; (2) Ventilation (3) (4) group. (50 mg/kg) injected intraperitoneally 1h before operation. Mouse vascular endothelial cells...
Metallo-β-lactamases (MBLs) represent a prevalent resistance mechanism in Gram-negative bacteria, rendering last-line carbapenem-related antibiotics ineffective. Here, bioresponsive sliver peroxide (Ag
Polyploidization presents an unusual challenge for species with sex chromosomes, as it can lead to complex combinations of chromosomes that disrupt reproductive development. This is particularly true allopolyploidization between different chromosome systems. Here, we assemble haplotype-resolved chromosome-level genomes a female allotetraploid weeping willow (Salix babylonica) and male diploid S. dunnii. We show arose from crosses ancestor the Salix-clade, which has XY on 7, Vetrix-clade,...
Sepsis, a lethal organ dysfunction caused by dysregulated host response to infection, is the leading cause of worldwide in-hospital mortality. However, early diagnostic methods for sepsis are still urgent guiding accurate antibiotic usage and improving survival rate patients. Herein, we constructed PD-L1 antibody affinity microfluidic (PAAM) chip diagnosis severity assessment. The was used capture PD-L1-expressing leukocytes from whole blood samples obtained healthy control (HC) volunteers...
Loss of endothelial barrier function plays an important role in the development ventilator-induced lung injury (VILI). This study aimed to investigate effects miR135a on VILI a model mechanical stretch (MS)-induced human umbilical vein cell (HUVEC) injury.HUVECs were randomly assigned 7 groups: blank, negative control (NC), NC+MS, over-expression (mi-miR135a), mi-miR135a + MS, silencing (si-miR135a) and si-miR135a MS groups. was induced by subjecting cells cyclic at 20% for 4 h. After 24 h,...
Sepsis is a global disease burden, and approximately 40% of cases develop acute lung injury (ALI). Bone marrow mesenchymal stromal cells (BMSCs) their exosomes are widely used in treating variety diseases including sepsis. As an phase protein, serum amyloid A1 (SAA1) regulates inflammation immunity. However, the role SAA1 BMSCs-exosomes septic remains to be elucidated. Exosomes derived from BMSCs were isolated by ultracentrifugation. was silenced or overexpressed mouse using lentiviral...