A5079966330- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Conducting polymers and applications
- Electrochemical sensors and biosensors
- Biosensors and Analytical Detection
- Electrochemical Analysis and Applications
- MicroRNA in disease regulation
- Analytical Chemistry and Sensors
- Antimicrobial Peptides and Activities
- Microfluidic and Bio-sensing Technologies
- Single-cell and spatial transcriptomics
- Diamond and Carbon-based Materials Research
- Graphene and Nanomaterials Applications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Extracellular vesicles in disease
- Advanced Nanomaterials in Catalysis
- Boron and Carbon Nanomaterials Research
- RNA and protein synthesis mechanisms
- Nanoparticle-Based Drug Delivery
- Nanocluster Synthesis and Applications
- Adenosine and Purinergic Signaling
- Molecular Junctions and Nanostructures
- Parasites and Host Interactions
- Genetics, Aging, and Longevity in Model Organisms
- COVID-19 Impact on Reproduction
State Key Laboratory of Oncogene and Related Genes
2017-2025
Shanghai Jiao Tong University
2015-2025
XinHua Hospital
2023-2025
Shanghai Cancer Institute
2024
Sungkyunkwan University
2010-2013
Abstract Patients with polycystic kidney disease (PKD) encounter a high risk of clear cell renal carcinoma (ccRCC), malignant tumor dysregulated lipid metabolism. SET domain–containing 2 (SETD2) has been identified as an important suppressor and immunosuppressor in ccRCC. However, the role SETD2 ccRCC generation PKD remains largely unexplored. Herein, we perform metabolomics, lipidomics, transcriptomics proteomics within loss induced PKD-ccRCC transition mouse model. Our analyses show that...
Using a single-stranded DNA (ssDNA) aptamer exhibiting high binding affinity (K d = 12 nM) to endotoxin as probe, an impedance sensor where aptamer-conjugated gold nanoparticles (AuNPs) were electrochemically deposited on electrode was fabricated and its performance in regard detection assessed. AuNPs have been employed widely biosensors because of their unique physical chemical properties. In order maximize the aptasensor detection, some critical factors affecting conjugation target...
Sepsis, a lethal organ dysfunction caused by dysregulated host response to infection, is the leading cause of worldwide in-hospital mortality. However, early diagnostic methods for sepsis are still urgent guiding accurate antibiotic usage and improving survival rate patients. Herein, we constructed PD-L1 antibody affinity microfluidic (PAAM) chip diagnosis severity assessment. The was used capture PD-L1-expressing leukocytes from whole blood samples obtained healthy control (HC) volunteers...
Infections from parasitic nematodes (or roundworms) contribute to a significant disease burden and productivity losses for humans livestock. The limited number of anthelmintics antinematode drugs) available today treat these infections are rapidly losing their efficacy as multidrug resistance in parasites becomes global health challenge. We propose an engineering approach discover anthelmintic drug combination that is more potent at killing wild-type Caenorhabditis elegans worms than four...
Conventional glass-based pH sensors are usually fragile and space consuming. Herein, a miniature electrochemical sensor based on amino-functionalized graphene fragments polyaniline (NH <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> -G/PANI) composite film is developed via simply one-pot polymerization the ITO-coated glass substrates. Cyclic Voltammetry (CV), Scanning Electron Microscopy (SEM), Transmission electron microscopy (TEM),...
Systemic Lupus Erythematosus (SLE) etiopathogenesis highlights the contributions of overproduction CD4
Abstract Neatly arranged gold nanoparticles (AuNPs) were directly electrodeposited on an electrochemically polymerized self‐assembled monolayer (SAM) of thiol‐functionalized 3,4‐ethylenedioxythiophene (EDOT) derivative, EDTMSHA. A thiolated single‐stranded DNA (ssDNA) aptamer with high specificity to LPS was immobilized the AuNPs/conducting polymer composite film, serving as sensing platform for detection. Electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), scanning...
Abstract The boosting exploitation of graphene oxide (GO) increases exposure risk to human beings. However, as primary defender in the first immune line, neutrophils’ mechanism defensive behavior toward GO remains unclear. Herein, we discovered that neutrophils recognize and defensively degrade a lateral dimension dependent manner. micrometer‐sized (mGO) induces NETosis by releasing neutrophil extracellular traps (NETs), while nanometer‐sized (nGO) elicits degranulation. two behaviors are...
Tumor-derived extracellular vesicles (EVs) carry tumor-specific proteins and RNAs, thus becoming prevalent targets for early cancer diagnosis. However, low expression of EV cargos insufficient diagnostic power individual biomarkers hindered EVs application in clinical practice. Herein, we propose a multiplex Codetection platform RNAs (Co-PAR) EVs. Co-PAR adopted pair antibody-DNA probes to recognize the same target protein, which turn formed double-stranded DNA. Thus, protein could be...
Protein coating is a strategy for modifying and improving the surface functional properties of nanomaterials.
Abstract Pancreatic cancer, at unresectable advanced stages, presents poor prognoses, which could be prevented by early pancreatic cancer diagnosis methods. Recently, a promising early-stage biomarker, extracellular vesicles (EVs) related glypican-1 (GPC1) mRNA, is found to overexpress in cells. Current mRNA detection methods usually require expensive machinery, strict preservation environments, and time-consuming processes guarantee sensitivity, specificity, stability. Herein, we propose...