A5071995219- Advanced Harmonic Analysis Research
- Immune Cell Function and Interaction
- Holomorphic and Operator Theory
- Advanced Mathematical Physics Problems
- Nonlinear Partial Differential Equations
- Advanced Cellulose Research Studies
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Surface Modification and Superhydrophobicity
- Histone Deacetylase Inhibitors Research
- Advanced Proteomics Techniques and Applications
- Autophagy in Disease and Therapy
- Biosensors and Analytical Detection
- Ubiquitin and proteasome pathways
- Aerogels and thermal insulation
- Nanoparticle-Based Drug Delivery
- Mass Spectrometry Techniques and Applications
- Mathematical Analysis and Transform Methods
- Microfluidic and Bio-sensing Technologies
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Single-cell and spatial transcriptomics
- Cell death mechanisms and regulation
- Advanced Banach Space Theory
- Polymer Surface Interaction Studies
Shanghai Jiao Tong University
2018-2025
The First People's Hospital of Wenling
2025
Xinjiang University
2020-2024
Qinghai University
2021-2024
Shenzhen Institutes of Advanced Technology
2024
Chinese Academy of Sciences
2024
State Key Laboratory of Oncogene and Related Genes
2021-2023
XinHua Hospital
2023
Tongren Hospital
2020-2021
Beijing Friendship Hospital
2021
We report on an efficient method for the formation of modified cellulose-based materials with enhanced hydrophobic properties, formed by grafting polymeric epoxidized soybean oil (ESO) as a renewable, environmentally friendly, and low cost raw material. The process occurred via ring-opening polymerization, wherein cellulose hydroxyl groups acted initiators in presence SnCl4 catalyst, linking fibers ESO ether linkages, thereby forming matrix. surface polarity was therefore decreased...
The absorbent materials synthesized from biosources with low cost and high selectivity for oils organic solvents have attracted increasing attention in the field of oil spillage discharge chemicals. We developed a convenient surface-grafting method to prepare efficient recyclable biobased aerogels epoxidized soybean (ESO)-modified cellulose at room temperature. porous network-like structure aerogel was still fully retained after undergoing hydrophobic modification ESO. Moreover, modified...
The functional integrity of Treg cells is interwoven with cellular metabolism; however, the mechanisms governing cell metabolic programs remain elusive. Here, we identified that deubiquitinase USP47 inhibited RNA m6A reader YTHDF1-mediated c-Myc translation to maintain and homeostasis. positively correlated tumor-infiltrating signature in colorectal cancer gastric patient samples. ablation compromised homeostasis function vivo, resulting development inflammatory disorders, boosted antitumor...
Abstract Patients with polycystic kidney disease (PKD) encounter a high risk of clear cell renal carcinoma (ccRCC), malignant tumor dysregulated lipid metabolism. SET domain–containing 2 (SETD2) has been identified as an important suppressor and immunosuppressor in ccRCC. However, the role SETD2 ccRCC generation PKD remains largely unexplored. Herein, we perform metabolomics, lipidomics, transcriptomics proteomics within loss induced PKD-ccRCC transition mouse model. Our analyses show that...
The CD4+CD25+FOXP3+ regulatory T (Treg) cells are critical for maintaining immune tolerance in healthy individuals and reported to restrict anti-inflammatory responses thereby promote tumor progression, suggesting them as a target the development of antitumor immunotherapy. Forkhead box P3 (FOXP3) is key transcription factor governing Treg lineage differentiation their immune-suppressive function. Here, using cells, well HEK-293T Jurkat we report that stability FOXP3 directly positively...
The cellulose aerogels were prepared by crosslinking of with 1,4-butanediol diglycidyl in NaOH/urea aqueous solution.
Proper metabolic activities facilitate T cell expansion and antitumor function; however, the mechanisms underlying disruption of program function in tumor microenvironment (TME) remain elusive. Here, we show a zinc finger protein 91–governed (ZFP91-governed) mechanism that disrupts pathway activity tumor-infiltrating cells. Single-cell RNA-Seq revealed impairments proliferation activation correlated with ZFP91 tissue samples from patients colorectal cancer. cell–specific deletion Zfp91 mice...
Abstract Mass spectrometry has emerged as a mainstream technique for label‐free proteomics. However, proteomic coverage trace samples is constrained by adsorption loss during repeated elution at sample pretreatment. Here, we demonstrated superparamagnetic composite nanoparticles functionalized with molecular glues (MGs) to enrich proteins in human biofluid. We showed high protein binding (>95 %) and recovery (≈90 rates anchor‐nanoparticles. further proposed Streamlined Workflow based on...
Autophagy programs the metabolic and functional fitness of regulatory T (T reg) cells to establish immune tolerance, yet mechanisms governing autophagy initiation in reg remain unclear. Here, we show that E3 ubiquitin ligase ZFP91 facilitates activation sustain cell programming integrity. cell–specific deletion Zfp91 caused dysfunction exacerbated colonic inflammation inflammation-driven colon carcinogenesis. TCR-triggered induction largely relied on cell–derived restrict hyperglycolysis,...
Abstract Background The increasing incidence of prostate cancer (PCa) indicates an urgent need for the development new effective drugs in PCa therapy. Triptonide has been reported to have a strong inhibition activity cancers through screening Chinese herbal medicine. This study aims investigate effects triptonide on anti‐PCa and its mechanisms. Methods Three human advanced cell lines PC3, DU145, LNCap, normal epithelial line RWPE were treated with range (0, 1.25, 2.5, 5, 10, 20, 40, 80, 160,...
Regulatory T cells (Treg cells) are essential for maintaining immune tolerance, and the dysfunction of Treg may cause autoimmune diseases tumors. Forkhead box P3 (FOXP3) is key transcription factor controlling cell development suppressive function. Mouse double minute 2 homolog (MDM2), an E3 ubiquitin ligase, has been identified as oncoprotein that mediates ubiquitination degradation tumor suppressor p53; however, whether it functions in remains unknown. Here, we demonstrate MDM2 positively...
Abstract Phosphomolybdate-based nanoparticles (PMo 12 -based NPs) have been commonly applied in nanomedicine. However, upon contact with biofluids, proteins are quickly adsorbed onto the NPs surface to form a protein corona, which induces opsonization and facilitates rapid clearance of by macrophage uptake. Herein, we introduce family structurally homologous PMo (CDS-PMo @PVP x (x = 0 ~ 1) capping diverse content zwitterionic polymer poly ( N -vinylpyrrolidone) (PVP) regulate corona...
Mass cytometry by time-of-flight (CyTOF), a high-dimensional single-cell analysis platform, detects up to 50 biomarkers at resolution. However, CyTOF of biological samples with minimal number available cells or rare cell subsets remains major technical challenge due the extensive loss during recovery, staining, and acquisition. Here, we introduce platinum-chimeric carrier strategy for mass profiling ultratrace samples. Cisplatin can rapidly enter broken plasma membranes dead form chimeric...
In 2011, Dekel et al. developed highly geometric Hardy spaces Hp(Θ), for the full range 0<p≤1, which were constructed by continuous multi-level ellipsoid covers Θ of Rn with high anisotropy in sense that ellipsoids can rapidly change shape from point to and level level. this article, when level, authors further obtain some real-variable characterizations Hp(Θ) terms radial, non-tangential, tangential maximal functions, generalize known results on anisotropic Bownik.
Abstract Mass spectrometry has emerged as a mainstream technique for label‐free proteomics. However, proteomic coverage trace samples is constrained by adsorption loss during repeated elution at sample pretreatment. Here, we demonstrated superparamagnetic composite nanoparticles functionalized with molecular glues (MGs) to enrich proteins in human biofluid. We showed high protein binding (>95 %) and recovery (≈90 rates anchor‐nanoparticles. further proposed Streamlined Workflow based on...
Let $X$ be a ball quasi-Banach function space, $\alpha\in \mathbb{R}$ and $q\in(0,\infty)$. In this paper, the authors first introduce new Herz-type Hardy spaces $\mathcal{H\dot{K}}_{X}^{\alpha,\,q}({\mathbb {R}}^n)$ $\mathcal{HK}_{X}^{\alpha,\,q}({\mathbb associated with space $X$, via non-tangential grand maximal function. Then, under some mild assumptions on establish real-variable theory for {R}}^n)$, in terms of characterizations, atomic molecular decompositions, obtain boundedness...